%PDF-1.7
%
1 0 obj
<<
/PageMode /UseOutlines
/Names 2 0 R
/Outlines 3 0 R
/Metadata 4 0 R
/Pages 5 0 R
/PageLayout /SinglePage
/OpenAction [6 0 R /FitH 810]
/Threads [7 0 R 8 0 R]
/StructTreeRoot 9 0 R
/Type /Catalog
/PageLabels 10 0 R
>>
endobj
11 0 obj
<<
/CrossMarkDomains#5B2#5D (elsevier.com)
/CrossmarkMajorVersionDate (2010-04-23)
/CreationDate (30th January 2019)
/Subject (Cell Metabolism, 29 \(2019\) 430-446. doi:10.1016/j.cmet.2018.10.003)
/Author (Jakob G. Knudsen)
/CreationDate--Text (30th January 2019)
/Creator (Elsevier)
/grabs (true)
/Producer (Acrobat Distiller 8.1.0 \(Windows\))
/ElsevierWebPDFSpecifications (6.5)
/CrossmarkDomainExclusive (true)
/robots (noindex)
/ModDate (D:20190131013330+05'30')
/doi (10.1016/j.cmet.2018.10.003)
/CrossMarkDomains#5B1#5D (sciencedirect.com)
/Title (Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production)
>>
endobj
2 0 obj
<<
/Dests 12 0 R
>>
endobj
3 0 obj
<<
/First 13 0 R
/Count 41
/Last 13 0 R
/Type /Outlines
>>
endobj
4 0 obj
<<
/Length 8097
/Subtype /XML
/Type /Metadata
>>
stream
application/pdf
doi:10.1016/j.cmet.2018.10.003
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production
Jakob G. Knudsen
Alexander Hamilton
Reshma Ramracheya
Andrei I. Tarasov
Melissa Brereton
Elizabeth Haythorne
Margarita V. Chibalina
Peter Spégel
Hindrik Mulder
Quan Zhang
Frances M. Ashcroft
Julie Adam
Patrik Rorsman
glucagon
Fh1
succination
sodium-glucose co-transport
diabetes
Cell Metabolism, 29 (2019) 430-446. doi:10.1016/j.cmet.2018.10.003
Elsevier Inc.
journal
Cell Metabolism
© 2018 The Author(s). Published by Elsevier Inc.
1550-4131
29
2
5 February 2019
2019-02-05
430-442.e4
430
442.e4
10.1016/j.cmet.2018.10.003
https://doi.org/10.1016/j.cmet.2018.10.003
2010-04-23
true
10.1016/j.cmet.2018.10.003
elsevier.com
sciencedirect.com
VoR
6.5
10.1016/j.cmet.2018.10.003
noindex
true
2010-04-23
true
30th January 2019
sciencedirect.com
elsevier.com
Elsevier
2019-01-31T01:33:30+05:30
2019-01-31T01:33:30+05:30
True
30th January 2019
Acrobat Distiller 8.1.0 (Windows)
uuid:235cf400-1e25-4366-9cbe-a72f6dccf80c
uuid:255fca9f-8ec5-47b7-b8df-52aff288df43
http://creativecommons.org/licenses/by/4.0/
endstream
endobj
5 0 obj
<<
/Count 19
/Type /Pages
/Kids [14 0 R 15 0 R 16 0 R]
>>
endobj
6 0 obj
<<
/CropBox [0 0 602.986 782.986]
/Annots [17 0 R 18 0 R 19 0 R 20 0 R]
/Parent 14 0 R
/B [21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R]
/StructParents 1
/Contents [31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R]
/Rotate 0
/MediaBox [0 0 602.986 782.986]
/Resources 39 0 R
/Type /Page
>>
endobj
7 0 obj
<<
/F 21 0 R
/I 40 0 R
>>
endobj
8 0 obj
<<
/F 41 0 R
/I 42 0 R
>>
endobj
9 0 obj
<<
/K [43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R]
/ParentTree 51 0 R
/ParentTreeNextKey 9
/Type /StructTreeRoot
>>
endobj
10 0 obj
<<
/Nums [0 52 0 R 14 53 0 R 30 54 0 R]
>>
endobj
12 0 obj
<<
/Kids [55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R]
>>
endobj
13 0 obj
<<
/First 61 0 R
/Parent 3 0 R
/A 62 0 R
/Count 40
/Last 63 0 R
/Title
>>
endobj
14 0 obj
<<
/Parent 5 0 R
/Count 9
/Type /Pages
/Kids [64 0 R 6 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R]
>>
endobj
15 0 obj
<<
/Parent 5 0 R
/Count 5
/Type /Pages
/Kids [72 0 R 73 0 R 74 0 R 75 0 R 76 0 R]
>>
endobj
16 0 obj
<<
/Parent 5 0 R
/Count 5
/Type /Pages
/Kids [77 0 R 78 0 R 79 0 R 80 0 R 81 0 R]
>>
endobj
17 0 obj
<<
/Rect [354.954 482.287 472.535 492.264]
/Subtype /Link
/A 82 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
18 0 obj
<<
/Rect [354.954 470.324 484.214 480.302]
/Subtype /Link
/A 83 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
19 0 obj
<<
/Rect [104.598 48.359 270.482 56.863]
/Subtype /Link
/A 84 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
20 0 obj
<<
/Rect [53.121 56.126 69.109 72.113]
/Subtype /Link
/A 85 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
21 0 obj
<<
/N 22 0 R
/P 6 0 R
/R [50 679 295 684]
/T 7 0 R
/V 30 0 R
>>
endobj
22 0 obj
<<
/N 23 0 R
/P 6 0 R
/R [50 710 546 736]
/T 7 0 R
/V 21 0 R
>>
endobj
23 0 obj
<<
/N 24 0 R
/P 6 0 R
/R [50 667 295 721]
/T 7 0 R
/V 22 0 R
>>
endobj
24 0 obj
<<
/N 25 0 R
/P 6 0 R
/R [50 619 546 688]
/T 7 0 R
/V 23 0 R
>>
endobj
25 0 obj
<<
/N 26 0 R
/P 6 0 R
/R [50 593 295 613]
/T 7 0 R
/V 24 0 R
>>
endobj
26 0 obj
<<
/N 27 0 R
/P 6 0 R
/R [50 596 295 614]
/T 7 0 R
/V 25 0 R
>>
endobj
27 0 obj
<<
/N 28 0 R
/P 6 0 R
/R [50 273 289 293]
/T 7 0 R
/V 26 0 R
>>
endobj
28 0 obj
<<
/N 29 0 R
/P 6 0 R
/R [50 130 346 277]
/T 7 0 R
/V 27 0 R
>>
endobj
29 0 obj
<<
/N 30 0 R
/P 6 0 R
/R [50 109 295 125]
/T 7 0 R
/V 28 0 R
>>
endobj
30 0 obj
<<
/N 21 0 R
/P 6 0 R
/R [352 284 546 613]
/T 7 0 R
/V 29 0 R
>>
endobj
31 0 obj
<<
/Length 1373
/Filter /FlateDecode
>>
stream
HlWr7W"@$rrO[8e˩~{~ b{$=?W=Q-ru?;ⅲBՇ=`*>~~}-Ӈ7ܞ>s&,b}}r[,N8$i}^?7?:cw{dqffvÁq1\49
oJ2y
BH<DbS#ڎĆہ/6j.KAγ%J]lVs%
%~h0)sZP]}*͜$> h4BV2ƒ4v#3ϵdY$5qpuPT6&X#h]բ.oJ#](@k0DPׅWX"\p$#
3cxaшcxJh#b/:Lyt[9-$&Wv39,M߈9Yn3!l砶|Ό ujmn(\F;B`k=QvJ4vr5ӡ~^Գ K=UX^7h 0`cz~/#R_
")u(|ĝK= +'A&C}!' `nE AN0Z6)ԍML<)2P
n2cC#Ń%L8xQC +Ѭ%(SŔ̔)T'UfnWȷ!z٬U-{tThGNܟ'<1lm+H^'ƞ^@=O/qI({3X OhXᮮTV>bzm yUAFK j!.Z^z J:uLǭr nHĵٴ0fXCO. UfJ1M:fbƇNG
fDROoJ_Z,
"pHٓ(Io BMsP.Aq/τլSb+[GRYL름:Nt:+W-g>$rAI돑:cAgƢM# {0T
[Gx0cj:CE734qeܠ4`ETH}Gh,$Cq+'R%T4z<(%!]"VLj'g#fgtYnsH/
}uNӹnTgV|x $C'rtxwK4OrYX,!a%"RqLJ!{s=i7ȎO ;
endstream
endobj
32 0 obj
<<
/Length 1371
/Filter /FlateDecode
>>
stream
HWK6WH1W|4i-"i|+zPd/^7|Hvb)
8y7CGԂ{7UY UsgD\;W&wVBZ*(yVL3!c
E| U@)kF\ѥ3 ws/}70H$R2c
@sNv4{?W
ͺxk
eYdV/nXo/mŏsۭHEr>Vn;vU?G[\#fE4ި\ːϥ&h
ʀUX[&qӷ͖e/?CӞKvxo\clw>͗¿N)}> ǛVI)6*#f3(ҽν̱5Mar'Y γ~?Q1d 6bk59uU X=:>v]RO]K$ &<1)ePZ67yN7m~u`~}ɯ+e&pNmSGEx1ه? lX\*!5੍MC%w^·hñ9Rב;>&dOj*}sC];je^WRTz>tRîDba^1.j1-*F`(ċi}VuZѼadg* :NVqԯMޜ>P