%PDF-1.7
%
1 0 obj
<<
/PageMode /UseThumbs
/ViewerPreferences 2 0 R
/Metadata 3 0 R
/Pages 4 0 R
/PageLayout /SinglePage
/OpenAction [5 0 R /FitH 9000]
/Type /Catalog
>>
endobj
6 0 obj
<<
/CreationDate (D:20191019101058Z)
/Subject (Biochimie, Journal Pre-proof. doi:10.1016/j.biochi.2019.10.007)
/Author (Mariano A. Scorciapino)
/Creator (Elsevier)
/Producer (itext-paulo-155 \(itextpdf.sf.net-lowagie.com\))
/ElsevierWebPDFSpecifications (6.5)
/ModDate (D:20191019154146+05'30')
/doi (10.1016/j.biochi.2019.10.007)
/Title (Conformational analysis and in vitro immunomodulatory and insulinotropic properties of the frog skin host-defense peptide rhinophrynin-27 and selected analogs)
>>
endobj
2 0 obj
<<
/NonFullScreenPageMode /UseNone
/FitWindow true
>>
endobj
3 0 obj
<<
/Length 6224
/Subtype /XML
/Type /Metadata
>>
stream
application/pdf
doi:10.1016/j.biochi.2019.10.007
Conformational analysis and in vitro immunomodulatory and insulinotropic properties of the frog skin host-defense peptide rhinophrynin-27 and selected analogs
Mariano A. Scorciapino
Paola Carta
Jelena Pantic
Miodrag L. Lukic
Aleksandra Lukic
Vishal Musale
Yasser H.A. Abdel-Wahab
J. Michael Conlon
Rhinophrynin-27
frog skin
cytokine
insulin release
Type 2 diabetes
anti-inflammatory
Biochimie, Journal Pre-proof. doi:10.1016/j.biochi.2019.10.007
Société Française de Biochimie et Biologie Moléculaire (SFBBM)
journal
Biochimie
© 2019 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.
0300-9084
10.1016/j.biochi.2019.10.007
https://doi.org/10.1016/j.biochi.2019.10.007
P
10.1016/j.biochi.2019.10.007
Elsevier
2019-10-19T10:10:58Z
2019-10-19T15:41:46+05:30
2019-10-19T15:41:46+05:30
True
itext-paulo-155 (itextpdf.sf.net-lowagie.com)
uuid:1147294b-9e5c-4317-b64b-cb857dca716b
uuid:20b05712-3866-4c96-8000-25286eb5bae7
endstream
endobj
4 0 obj
<<
/Count 37
/Type /Pages
/Kids [7 0 R 5 0 R 8 0 R 9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R
16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R
26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R
36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R]
>>
endobj
5 0 obj
<<
/CropBox [0 0 612 709]
/Annots [43 0 R 44 0 R]
/Parent 4 0 R
/Contents [45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R]
/Rotate 0
/BleedBox [0 0 612 709]
/MediaBox [0 0 612 709]
/TrimBox [0 0 612 709]
/Resources 53 0 R
/Type /Page
>>
endobj
7 0 obj
<<
/Contents 54 0 R
/Type /Page
/Resources <<
/Font <<
/F1 55 0 R
/F2 56 0 R
/F3 57 0 R
>>
/XObject <<
/Xf1 58 0 R
>>
>>
/Annots [59 0 R 60 0 R 61 0 R]
/Parent 4 0 R
/MediaBox [0 0 595 842]
>>
endobj
8 0 obj
<<
/CropBox [0 0 612.283 793.701]
/Parent 4 0 R
/Contents [62 0 R 63 0 R]
/Rotate 0
/Group 64 0 R
/MediaBox [0 0 612.283 793.701]
/Resources 65 0 R
/Type /Page
>>
endobj
9 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [66 0 R 67 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 68 0 R
/Type /Page
>>
endobj
10 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [69 0 R 70 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 71 0 R
/Type /Page
>>
endobj
11 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [72 0 R 73 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 74 0 R
/Type /Page
>>
endobj
12 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [75 0 R 76 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 77 0 R
/Type /Page
>>
endobj
13 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [78 0 R 79 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 80 0 R
/Type /Page
>>
endobj
14 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [81 0 R 82 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 83 0 R
/Type /Page
>>
endobj
15 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [84 0 R 85 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 86 0 R
/Type /Page
>>
endobj
16 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [87 0 R 88 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 89 0 R
/Type /Page
>>
endobj
17 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [90 0 R 91 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 92 0 R
/Type /Page
>>
endobj
18 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [93 0 R 94 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 95 0 R
/Type /Page
>>
endobj
19 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [96 0 R 97 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 98 0 R
/Type /Page
>>
endobj
20 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [99 0 R 100 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 101 0 R
/Type /Page
>>
endobj
21 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [102 0 R 103 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 104 0 R
/Type /Page
>>
endobj
22 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [105 0 R 106 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 107 0 R
/Type /Page
>>
endobj
23 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [108 0 R 109 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 110 0 R
/Type /Page
>>
endobj
24 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [111 0 R 112 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 113 0 R
/Type /Page
>>
endobj
25 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [114 0 R 115 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 116 0 R
/Type /Page
>>
endobj
26 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [117 0 R 118 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 119 0 R
/Type /Page
>>
endobj
27 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [120 0 R 121 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 122 0 R
/Type /Page
>>
endobj
28 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [123 0 R 124 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 125 0 R
/Type /Page
>>
endobj
29 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [126 0 R 127 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 128 0 R
/Type /Page
>>
endobj
30 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [129 0 R 130 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 131 0 R
/Type /Page
>>
endobj
31 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [132 0 R 133 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 134 0 R
/Type /Page
>>
endobj
32 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [135 0 R 136 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 137 0 R
/Type /Page
>>
endobj
33 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [138 0 R 139 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 140 0 R
/Type /Page
>>
endobj
34 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [141 0 R 142 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 143 0 R
/Type /Page
>>
endobj
35 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [144 0 R 145 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 146 0 R
/Type /Page
>>
endobj
36 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [147 0 R 148 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 149 0 R
/Type /Page
>>
endobj
37 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [150 0 R 151 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 152 0 R
/Type /Page
>>
endobj
38 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [153 0 R 154 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 155 0 R
/Type /Page
>>
endobj
39 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [156 0 R 157 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 158 0 R
/Type /Page
>>
endobj
40 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [159 0 R 160 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 161 0 R
/Type /Page
>>
endobj
41 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [162 0 R 163 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 164 0 R
/Type /Page
>>
endobj
42 0 obj
<<
/CropBox [0 0 595 842]
/Parent 4 0 R
/Contents [165 0 R 166 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 167 0 R
/Type /Page
>>
endobj
43 0 obj
<<
/Rect [143.7 463.376 335.36 472.746]
/Subtype /Link
/A 168 0 R
/C [0 0 0]
/H /I
/Border [0 0 0]
/Type /Annot
>>
endobj
44 0 obj
<<
/Rect [70 274.376 261.66 283.746]
/Subtype /Link
/A 169 0 R
/C [0 0 0]
/H /I
/Border [0 0 0]
/Type /Annot
>>
endobj
45 0 obj
<<
/Length 427
/Filter /FlateDecode
>>
stream
HTn0@iЙT[R;qN@mA>JJDCh~T_w7w7NAPg'bEsh-Mh3rS=ǝw#ڈcn]R7)dKJD6~G0 |r$9
'c:> QyP`C?
jq3Xg@,Yej8e-̕Z{1S1$c*<(2OcUe`s)[d(4'n3YyC"B}O:,gl>+t=:t
UBQT1p^į N#|FD&-1od)"$Z[b^~',1ȘsKU4mF-.5G #u
endstream
endobj
46 0 obj
<<
/Length 366
/Filter /FlateDecode
>>
stream
HSMk0WG0
Mz6vl0d+KJڱr,I~s{P<'@
,58bAmvq+7W7X}8}d+,f=')Lw`5v4?g*A>j@;VCpɇ{ y2[6{yu(HlMCg\śE)%uq3NRʤT;m=3ǘr8,kGI9]Ωk|:MUޥj'0j_~
endstream
endobj
47 0 obj
<<
/Length 387
/Filter /FlateDecode
>>
stream
H=o0w~Ev(HIЭ[uөUNUR;-NpyN x+s_y5ֶڔ8:AIaHi#-_>n^UnA]oY3d=Z
l뇹:)V͋q6JFBF̓bpRIŞjbBp
sL`CǞEhDg1ɷT TW]]k\vĝԲs"SғR~uJyÊ2?ꑙU^#0du!'82HZəS|9W5k+K"1+~uͿ,9^x<'>Է #
endstream
endobj
48 0 obj
<<
/Length 352
/Filter /FlateDecode
>>
stream
HSn +e6@iR$svm
T[#d
n/lHW5
(|BdhuY;yV1?Fhx5oXv|#oԊDcFd+UIٚFВ7la2^E颡8%{xa7tqYC SBvU?%~bsA>EճcK)Vvv,fnnpc~O=j)_am=T1jG, =kTj
e=v'̶_@>6tVs` e
endstream
endobj
49 0 obj
<<
/Length 372
/Filter /FlateDecode
>>
stream
HS!F6̅E#Sl.J6l< ux7o&\F5/rljIJN2ZzHOd;CO;-I>JkgW+r_j+xEo ~