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T*
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[(p)-5.8(a)18.5(t)-7.1(h)22.3(wa)17.6(y)-237(r)12(es)5.2(p)-9.4(o)10.9(n)7.3(s)-8.3(es;)-237.6(i)-0.7(n)18.1(t)5.6(eg)-5.8(ra)18.5(t)-6.2(i)-0.7(n)7.3(g)-235.2(t)-7.1(h)3.3(es)-8.3(e)-237.6(d)-2.7(a)18.5(t)-7.1(a;)-238.5(u)-6(l)11.4(t)-6.2(i)-0.7(ma)18.5(t)5.6(e)3.6(l)6.9(y)-235.2(f)8.3(o)10.9(r)-7(m)18.2(u-)]TJ
T*
-0.0014 Tc
[(la)17.5(t)-7.2(i)-1.7(n)6.3(g)-206.4(ma)17.5(t)-8.1(h)2.3(ema)17.5(t)-7.2(ica)-6.9(l)-204.6(mo)-10.8(dels)-207.1(t)-8.1(h)1.4(a)17.5(t)-206.8(des)-9.3(cr)-8(ib)-10.1(e)-207.9(t)-8.1(he)-206.1(s)4.2(t)-7.2(r)-11.6(u)-1.6(c)-8.4(t)8.2(ur)11(e)-206.1(o)9.9(f)-206.8(t)-8.1(he)]TJ
T*
0.0001 Tc
[(sys)5.7(t)6.1(em)-290.3(a)9.1(n)3.3(d)-288.6(p)11.9(r)12.5(e)-4.9(dic)-6.9(t)-288.4(i)11.5(t)-0.2(s)-288.8(r)12.5(es)5.7(p)-8.9(o)11.4(n)7.8(s)-7.8(e)-288.6(t)6.1(o)-289.4(i)-0.2(ndi)7(v)-3(id)12.3(ua)-5.4(l)-287.1(p)-8.9(er)-10.1(t)9.7(u)-0.1(rb)-5(a)19(t)-5.7(io)11.4(n)7.8(s)0.3(.)]TJ
T*
-0.0022 Tc
[(I)14.5(n)16.3(teg)-7.6(r)-2.5(a)16.7(t)3.8(e)-7.2(d)-325.2()80.5(o)9.1(mics)38.7()-323(\()-2.2(such)-325.5(as)-324.5(geno)9.1(me-w)-4.7(ide)-325.2(m)1(e)-8.1(a)0.5(sur)10.2(e)-1.8(men)16.3(t)-2.5(s)-322.7(o)9.1(f)]TJ
T*
-0.0007 Tc
[(t)-6.5(r)-1(a)8.3(n)7(s)-8.6(c)-0.5(r)-7.3(i)10.7(p)10.2(t)-1(s,)-420.4(p)11.1(r)11.7(o)9.7(t)5.3(ein)-420.3(l)-0.6(e)-8.4(v)7(els,)-423.1(o)10.6(r)-421.1(met)-7.4(a)7.4(b)-9.4(o)6.1(li)10.7(t)5.3(e)-421.3(le)-8.4(v)7(e)3.3(l\))-422.6(a)18.2(p)10.2(p)11.1(r)11.7(o)-6.5(a)-0.7(c)5.8(h)3(es)]TJ
T*
-0.0071 Tc
[(ha)10.9(ve)-303(c)-6.9(r)5.3(e)-13(a)11.8(te)-12.1(d)-303(e)-6.7(xc)-6.9(i)4.3(t)-12.9(i)-7.4(n)0.6(g)-303.4(o)3.3(pp)-16.1(o)4.2(r)-17.3(tu)-7.3(n)-7.6(i)4.3(t)-12.9(i)-7.4(e)-6.7(s)-299.6(fo)4.2(r)-302.8(s)-6.9(y)-7(s)-1.5(te)-6.7(ms)-304.1(b)4.9(i)-7.4(ol)-7(o)-7.5(g)-31.4(y)-302.4(a)1.9(nd)]TJ
T*
-0.0018 Tc
[(o)8.6(t)-8.5(her)-254.1(b)10.2(iolog)-7.2(i)-2.1(c)-4.3(a)-7.3(l)-254.7(r)10.6(es)-9.7(e)-7.7(a)7.2(r)10.6(c)4.7(hes)-255.4(t)-8.5(ha)7.2(n)-7.7(k)-1.8(s)-253.6(t)4.2(o)-255.2(t)-8.5(he)-255.2(ra)17.1(p)10(i)-2.1(d)-254.3(a)-1.8(dva)7.2(n)1.4(cemen)16.7(t)]TJ
T*
-0.0004 Tc
[(o)10.9(f)-383.7(hig)-7.6(h)-385.1(t)-7.1(h)-0.3(r)12(o)10(ug)-7.6(h)18.7(p)10.5(u)11.2(t)-382(b)11.6(i)-0.7(o)10(t)5.6(e)-5.4(c)6.1(hno)6.4(l)-0.3(og)-5.8(ies.)-384(C)-15.7(o)10.9(m)18.2(p)10.5(u)11.2(t)-7.1(a)18.5(t)-6.2(io)10.9(na)-5.9(l)-379.8(m)2.8(et)-7.1(h-)]TJ
T*
-0.0006 Tc
[(o)-10(d)2.5(s)-415(s)5(uc)5.9(h)-415.2(a)2.1(s)-415(d)-2.9(a)18.3(t)-7.3(a)-414.4(p)11.2(r)11.8(e)-0.2(p)11.2(r)11.8(o)-10(c)-0.4(es)5(sin)7.1(g)-32.2(,)-414.9(r)11.8(ep)11.2(r)11.8(e)-0.2(s)-8.5(e)-0.2(n)17.9(t)-7.3(a)18.3(t)-6.4(io)10.7(n,)-411.3(mo)-10(delin)7.1(g)-32.2(,)]TJ
T*
[(me)-6.5(as)5(ur)11.8(emen)17.9(t,)-386.9(in)17.9(t)5.4(e)-0.2(r)-10.8(p)11.2(r)11.8(e)-0.2(t)-7.3(a)18.3(t)-6.4(i)-0.9(o)10.7(n)-1.1(,)-384.2(p)11.2(r)11.8(e)-5.6(dic)-7.6(t)-6.4(io)10.7(n,)-386(vis)5(u)-3.5(a)-6.1(l)-0.5(is)-6.7(a)18.3(t)-6.4(io)10.7(n,)-385.1(a)8.4(n)2.6(d)]TJ
T*
0.0001 Tc
[(sim)18.7(u)-5.5(la)19(t)-5.7(i)-0.2(o)11.4(n)-322(ha)18.1(v)7.8(e)-323.8(b)-8.6(e)-4.9(en)-325.6(w)8.5(e)4.1(l)-5.3(l)-324.2(a)19(p)11(p)7.4(l)0.2(ie)-4.9(d)-324.7(t)6.1(o)-324.6(u)-0.1(nder)6.1(s)5.7(t)-6.6(a)9.1(n)3.3(d)-322.9(b)12.1(io)6.9(log)-5.3(i)-0.2(ca)-5.4(l)]TJ
T*
-0.0004 Tc
[(p)11.4(r)12(o)-9.8(c)-0.2(es)5.2(s)-8.3(e)0(s)-227.8(a)8.6(nd)-226.7(b)11.6(i)-0.7(o)6.4(l)-0.3(og)-5.8(ica)-5.9(l)-226.2(sys)5.2(t)5.6(em)7.4(s.)]TJ
1.4996 -1.141 TD
0.1553 Tc
[(W)251.8(e)0.3(o)166.6(r)163.1(g)155.3(a)164.3(n)154.8(i)157.7(s)147.4(e)150.3(dt)148.6(h)155.4(i)157.7(ss)160.9(p)146.3(e)150.3(c)155.5(i)152.3(a)149.8(l)0(i)157.7(s)160.9(s)160.9(u)155.1(et)161.3(op)167.1(r)167.7(o)171.1(v)152.2(i)155(d)155.7(e)0.3(a)164.3(n)-0.5(i)155(n)173.8(t)161.3(e)155.7(r)148.7(n)157.6(a)174.2(t)149.5(i)155(o)166.6(n)157.6(a)149.8(l)]TJ
-1.4996 -1.141 TD
0.3142 Tc
[(f)322.9(o)325.5(r)304(u)314(mt)320.2(od)314.6(i)316.6(s)306.3(c)307.2(u)316.7(s)319.8(s)-0.9(t)307.5(h)317.9(em)317.4(o)313.8(s)319.8(tr)326.6(e)309.2(c)314.4(e)314.6(n)332.7(td)314.6(e)306.5(v)321.9(e)318.2(l)314.3(o)324.6(p)326(m)317.4(e)314.6(n)332.7(t)313.9(si)313.9(nt)307.5(h)317.9(e)0.2()314.4(e)318.2(l)314.3(d)]TJ
T*
-0.0113 Tc
[(re)-10.9(g)-11.3(a)-2.3(rd)-10.9(i)-11.6(n)-3.6(g)-509(i)-11.6(n)7.2(t)-5.3(e)-10.9(g)-16.7(r)-11.6(a)7.6(t)-5.3(e)-16.3(d)-509.5(d)-13.6(a)7.6(t)-18(a)-510(a)-2.3(n)-9(a)-16.8(l)-4(y)-11.2(s)-11.1(i)-8.9(s)-508.8(a)7.6(ppro)-17.1(a)-11.3(c)-4.8(h)-7.6(e)-10.9(s)-508.8(i)-11.6(n)-509.5(s)-11.1(y)-11.2(s)-5.7(t)-5.3(e)-10.9(ms)]TJ
0 -1.1419 TD
0.2497 Tc
[(b)261.7(i)249.4(o)256.5(l)249.8(o)249.3(g)225.4(yr)262.1(e)250.1(s)241.8(e)243.8(a)258.7(r)262.1(c)256.2(hs)255.3(u)249.5(c)256.2(ha)252.4(sp)244.3(a)268.6(t)259.3(t)255.7(e)250.1(r)243.1(n)-0.1(r)262.1(e)244.7(c)249.9(o)249.3(g)244.3(n)249.2(i)261.1(t)243.9(i)249.4(o)261(na)258.7(n)252.9(d)-0.1(p)261.5(r)262.1(e)244.7(d)250.1(i)249.4(c)242.7(t)243.9(i)249.4(o)261(n)249.2(,)]TJ
0 -1.141 TD
-0.0188 Tc
[(m)-15.6(o)-28.2(d)-18.4(e)-14.8(l)-18.7(i)-19.1(n)-11.1(g)-182.3(a)-9.8(n)-15.6(d)-181.9(s)-18.6(i)-19.1(m)-0.2(u)-24.4(l)-21.5(at)-24.6(i)-19.1(o)-7.5(n)-19.3(,)-182(a)-9.8(n)-15.6(d)-181.9(d)-21.1(at)-25.5(a)-182.4(r)-6.4(e)-18.4(p)-7(r)-6.4(e)-18.4(s)-26.7(e)-18.4(nt)-25.5(at)-24.6(i)-19.1(o)-7.5(n)-182.8(a)-9.8(n)-15.6(d)-181.9(v)-21.9(i)-16.4(s)-13.2(u)-21.7(a)-24.3(l)-18.8(-)]TJ
T*
[(i)-16.5(s)-25(at)-24.7(i)-19.2(o)-7.6(n)-19.4(.)-240.8()-19.3(i)-16.5(s)-242.7(s)-13.3(p)-27.9(e)-23.9(c)-18.7(i)-21.9(a)-24.4(l)-243.8(i)-16.5(s)-13.3(s)-13.3(u)-19.1(e)-243.4(f)-10.2(e)-24.8(a)0(t)-9.3(u)-19.1(r)-6.5(e)-23.9(d)-242.5()-27.4(i)-19.2(n)-0.4(t)-12.9(e)-18.5(g)-24.3(r)-19.2(at)-12.9(e)-23.9(d)-241.6(ap)-8(p)-7.1(r)-6.5(o)-24.7(a)-18.9(c)-12.4(h)63.4()-242.1(a)-9.9(n)-15.7(d)]TJ
T*
-0.0004 Tc
[()82.3(c)-0.2(o)10.9(m)18.2(p)6.9(l)-0.3(ex)-155.3(b)11.6(i)-0.7(o)6.4(l)-0.3(og)-5.8(ica)-5.9(l)-155.7(sys)5.2(t)5.6(em)81.4()-155.9(t)-7.1(hemes.)-155.4(W)96.1(e)-155.4(a)8.6(r)12(e)-155.4(i)-0.7(n)18.1(t)5.6(er)12(es)5.2(t)5.6(e)-5.4(d)-155.4(i)-0.7(n)-156.2(b)-9.1(o)10(t)-7.1(h)]TJ
T*
-0.0011 Tc
[(ne)-8.8(w)-175.2(t)-7.8(heo)10.2(r)-7.7(ies)-174.3(a)7.9(nd)-175(t)4.9(o)-10.5(o)5.7(l)1.7(s)-175.2(i)-1.4(n)-175.9(t)-7.8(his)-175.2(a)7.9(r)11.3(e)-7(a)-175.5(a)1.6(s)-176.1(w)7.3(el)-6.5(l)-175.4(a)1.6(s)-176.1(t)-7.8(heir)-174.8(a)17.8(p)9.8(p)6.2(l)-1(ica)17.8(t)-6.9(io)10.2(n)6.6(s)]TJ
T*
0.0001 Tc
[(in)-188.3(sys)5.7(t)6.1(em)7.9(s)-190.3(b)12.1(io)6.9(log)-24.2(y)73.4(.)-188.4()3.3(e)-187.4(p)-8.9(o)10.5(t)6.1(en)18.6(t)-5.7(i)-2.9(a)-5.4(l)-186.8(t)6.1(o)10.5(p)11.9(i)-0.2(cs)-188.5(inc)6.6(l)11.9(ude)-187.4(\()0.1(i\))-188.7(la)9.1(r)7.9(g)8.3(e-s)-7.8(c)-2.4(a)-5.4(l)0.2(e)]TJ
25.8998 31.9479 TD
-0.0108 Tc
[(or)-415.8(c)-10.6(r)1.6(o)-11.2(s)-5.2(s)-10.6(-)-10.7(s)-5.2(p)-19.8(e)-15.8(c)-10.6(i)-11.1(e)-10.4(s)-417.1(d)-13.1(a)8.1(t)-17.5(a)-416.5(i)-11.1(n)7.7(t)-4.8(e)-10.4(g)-16.2(r)-11.1(a)8.1(t)-16.6(i)-11.1(on)-413.3(for)-415.8(t)-17.5(h)-7.1(e)-415.1(re)-15.8(c)-10.6(o)0.5(ns)-5.2(t)-16.6(r)-21(u)-11(c)-17.8(t)-16.6(i)-11.1(on)-412.4(of)]TJ
0 -1.141 TD
-0.0004 Tc
[(netw)8(o)10.9(r)2.9(ks)-475.3(a)8.6(n)2.8(d)-475.2(p)-5.8(a)18.5(t)-7.1(h)22.3(w)-0.2(a)17.6(y)-0.3(s;)-475.2(\(ii\))-475.6(g)7.8(e)0(no)10.9(mic)-474.5(d)-2.7(a)18.5(t)-7.1(a)-475.6(a)8.6(na)-5.9(l)6.9(y)-0.3(sis)-475.3(u)2.1(sin)7.3(g)]TJ
T*
-0.0002 Tc
[(sys)5.4(t)5.8(em)7.6(s)-430.9(b)11.8(io)6.6(log)-24.5(y)-428.3(a)18.7(p)10.7(p)11.6(r)12.2(o)-6(a)-0.2(c)6.3(h)3.5(es;)-428.1(\()-0.2(iii\))-428.4(q)9.4(u)-3.1(a)8.8(n)18.3(t)-6(i)11.2(t)-6.9(a)18.7(t)-6(i)6.7(v)7.5(e)-426.2(under)5.8(s)5.4(t)-6.9(a)8.8(n)3(d-)]TJ
T*
-0.0004 Tc
[(in)7.3(g)-480.9(o)10.9(f)-481.3(t)-7.1(he)-480.6(d)7.2(y)-3(na)8.6(mics)-480.8(o)10.9(f)-481.3(r)12(e)0(gu)-6(la)18.5(t)5.6(o)10.9(r)-29.6(y)72.9(,)-480.7(s)-0.2(ig)-5.8(na)-5.9(lin)7.3(g)-32(,)-479.7(i)-0.7(n)18.1(t)5.6(erac)-7.4(t)-6.2(i)-0.7(o)10.9(n)-0.9(,)]TJ
T*
-0.0001 Tc
[(a)8.9(n)3.1(d)-357.4(m)3.1(et)-6.8(a)8(b)-8.8(o)6.7(l)-0.1(ic)-357.6(netw)8.3(o)11.2(r)3.2(ks)-356.7(t)-6.8(h)0(r)12.3(o)10.3(ug)-7.3(h)-355.9(m)3.1(o)-9.5(d)0.3(elin)7.6(g)-356(a)8.9(nd)-357.4(sim)18.5(u)-5.7(la)18.8(t)-5.9(i)-0.4(o)11.2(n)]TJ
T*
0 Tc
[(t)6(e)-5(c)6.5(h)0.1(niq)9.6(u)-0.2(es;)-469.4(\()0(i)6.9(v)-0.4(\))-468.8(p)11.8(r)12.4(e)-5(dic)-7(t)-5.8(io)11.3(n)-466.6(o)11.3(f)-468.3(p)11.8(r)12.4(o)10.4(t)6(e)0.4(in/RN)38.4(A)-468(s)5.6(t)-5.8(r)-10.2(uc)-7(t)9.6(u)-0.2(r)12.4(e)-466.6(a)9(n)3.2(d)]TJ
T*
0.0003 Tc
[(b)12.3(i)0(o)7.1(l)0.4(og)-5.1(ica)-5.2(l)-402.6(netw)8.7(o)11.6(r)3.6(k-b)-4.8(a)3(s)-7.6(e)-4.7(d)-402.2(i)0(n)18.8(t)6.3(erac)-6.7(t)-5.5(i)0(o)11.6(n)8(s;)-401.4(\(v\))-403.5(d)-2(a)19.2(t)-6.4(a)-404.5(i)0(n)18.8(t)6.3(eg)-5.1(ra)19.2(t)-5.5(i)0(o)11.6(n)]TJ
T*
-0.0007 Tc
[(a)8.3(n)2.5(d)-263.2(k)-4.3(no)15.1(w)-7.7(l)-0.7(e)-5.7(d)-0.3(g)7.5(e)-0.3(-dr)-7.3(i)6.2(v)7(e)-0.3(n)-263.1(a)18.2(p)10.2(p)11.1(r)11.7(o)-6.5(ac)5.8(h)-262.6(i)-1(n)-262.2(b)11.3(io)10.6(ma)8.3(rk)8.4(er)-262.1(iden)17.8(t)-6.5(i)-1(ca)18.2(t)-6.5(io)10.6(n)]TJ
T*
-0.0084 Tc
[(an)-5.2(d)-412.7(d)-8(r)-18.6(u)-8.6(g)-413.1(d)-8(i)-6(s)-16.3(c)-8.2(o)7.4(ve)-8(r)-37.6(y)-39(;)-413.7(\()-8.4(v)-11.5(i)-8.7(\))-412.2(e)-8(n)-14.3(h)-5.6(an)-5.2(c)-8.2(e)-8(m)-5.2(e)-8(n)10.1(t)-411.7(an)-5.2(d)-412.7(e)-8(n)-6.1(a)-0.3(bl)-8.4(e)-8(m)-5.2(e)-8(n)10.1(t)-412.6(o)2.9(f)]TJ
T*
-0.002 Tc
[(k)-5.6(n)1.2(o)13.8(w)-9(le)-7(dge)-299.7(d)-1.6(is)-9.9(co)13.8(ver)-31.2(y)-299.1(in)-298.8(f)-8.6(u)-2.2(nc)-9(t)-7.8(i)-2.3(o)9.3(n)0.3(a)-7.5(l)-294.6(geno)9.3(mics)-297.2(o)9.3(f)-298.6(dis)-9.9(e)-7.9(as)-9.9(e)-298.8(a)7(nd)]TJ
T*
0.0001 Tc
[(o)10.5(t)-6.6(her)-344.4(p)7.4(heno)10.5(typ)-8.9(e)0.5(s)-343.9(t)-6.6(hr)12.5(o)10.5(u)-0.1(g)-7.1(h)-343.1(in)18.6(t)6.1(e)0.5(g)-5.3(r)-0.2(a)19(t)6.1(ed)-343.7(o)11.4(m)-0.3(ics)-343.9(a)19(p)11(p)11.9(r)12.5(o)-5.7(ac)6.6(h;)-343.7(\(vii\))]TJ
T*
-0.0186 Tc
[(s)-26.5(e)-18.2(m)-16.3(a)-9.6(nt)-24.4(i)-18.9(c)-531.5(w)-10.2(e)-15.5(b)-18.3(s)-534.2(a)-9.6(n)-15.4(d)-533.1(o)-7.3(nt)-12.6(o)-11.8(l)-18.5(o)-19(g)-42.9(y)-18.5(-)-18.5(d)-18.2(r)-25.2(i)-11.7(v)-10.9(e)-18.2(n)-531.3(b)-6.6(i)-18.9(o)-11.8(l)-18.6(o)-19(g)-24(i)-18.9(c)-21.1(a)-24.1(l)-531.7(d)-20.9(at)-25.3(a)-532.7(i)-18.9(nt)-12.6(e)-18.2(-)]TJ
T*
-0.0003 Tc
[(g)-5.7(r)-0.6(a)18.6(t)-6.1(io)11(n)-403.7(m)2.9(et)-7(ho)-9.7(ds;)-404.7(\()-0.3(viii\))-404.1(de)-8(v)7.4(e)3.7(lo)10.1(p)11.5(m)2.9(en)18.2(t)-404.5(o)11(f)-405.3(i)-0.6(n)18.2(t)5.7(eg)-5.7(ra)18.6(t)5.7(e)-5.3(d)-404.6(s)-0.1(ys)5.3(t)5.7(e)0.1(m)7.5(s)]TJ
T*
-0.0098 Tc
[(bi)-10.1(ol)-9.7(o)-10.2(g)-34.1(y)-284.3(v)-13(i)-7.4(s)-4.2(u)-12.7(a)-15.3(l)-9.7(i)-7.4(s)-15.9(a)9.1(t)-15.6(i)-10.1(on)-281.3(an)-6.6(d)-284(a)-0.8(n)-7.5(a)-15.3(ly)-9.7(s)-9.6(i)-7.4(s)-284.2(t)-3.8(o)-19.2(o)-3(l)-7(s)-9.6(;)-284.1(\()-9.8(i)-10.1(x)-9.4(\))-284.4(d)-9.4(e)-17.5(v)-2.1(e)-5.8(l)-9.8(opm)-6.6(e)-9.4(n)8.7(t)-283.9(of)]TJ
T*
-0.0002 Tc
[(in)18.3(t)5.8(e)0.2(g)-5.6(r)-0.5(a)18.7(t)5.8(ed)-364.7(sys)5.4(t)5.8(em)7.6(s)-367.6(b)11.8(io)6.6(log)-24.5(y)-364.2(vis)5.4(u)-3.1(a)-5.7(l)-0.2(is)-6.3(a)18.7(t)-6(io)11.1(n)-362.9(a)8.8(nd)-365.6(a)8.8(n)2.1(a)-5.7(l)7.1(ysis)-364(t)5.8(o)-9.6(o)6.6(l)2.6(s;)]TJ
T*
0.0058 Tc
[(\()5.8(x)6.2(\))-215.5(i)5.5(n)24.3(t)11.8(e)6.2(g)0.4(r)5.5(a)24.7(ti)5.5(n)13.5(g)-211.9(a)24.7(p)16.7(p)17.6(r)18.2(oa)5.8(c)12.3(h)9.5(e)6.2(s)-213.5(i)5.5(n)-214.2(tr)5.5(a)14.8(n)13.5(s)6(i)17.2(ti)5.5(o)17.1(n)8.1(al)-210.1(b)17.8(i)5.5(o)17.1(i)5.5(n)5.3(f)14.5(o)17.1(r)-0.8(m)8.1(a)24.7(ti)5.5(c)6(s)-209(a)14.8(n)9(d)]TJ
T*
-0.0023 Tc
[(p)-11.3(e)-1.9(rs)-10.2(o)9(n)0(a)-7.8(l)-2.3(ize)-7.3(d)-227.7(me)-7.3(dicine.)]TJ
1.5005 -1.141 TD
-0.0102 Tc
[(E)-10.4(i)-10.5(g)-17.4(h)8.9(t)-443.3(m)-7.9(an)8.3(u)-7.7(s)-18.1(c)-10(r)-16.8(ipt)-10.5(s)-441.8(we)-9.8(re)-444.3(s)-4.6(u)-6.8(bm)-10.6(itt)-4.2(e)-15.2(d)-442.5(i)-10.5(n)-444.3(r)2.2(e)-9.8(s)-4.6(p)-19.2(o)1.1(ns)-18.1(e)-443.4(t)-4.2(o)-444.2(t)-16.9(h)-10.1(i)-7.8(s)]TJ
-1.5005 -1.141 TD
-0.0052 Tc
[(sp)-14.2(e)-10.2(c)-5(i)-8.2(a)-10.7(l)-389.1(i)-2.8(ssu)-5.4(e)-388.7(a)3.8(nd)-387.8(s)-5(i)-5.5(x)-387.8(w)3.2(e)-4.8(r)7.2(e)-388.7()-5(na)-10.7(l)-10.6(l)2.1(y)-387.2(a)-5.2(c)-5(c)-5(e)-4.8(p)5.7(t)0.8(e)-10.2(d)-388.7(fo)6.1(r)-387.6(p)5.7(ubl)-5.1(i)-5.5(c)-7.7(a)13.7(t)-11(i)-5.5(o)6.1(n)-5.7(,)]TJ
T*
-0.001 Tc
[(ra)8(n)6.7(g)-6.4(in)6.7(g)-319.8(f)-11.2(r)11.4(o)10.3(m)-319.4(m)1.3(a)17.9(t)-7.7(hema)17.9(t)-6.8(i)-1.3(ca)-6.5(l)-318(m)2.2(o)-10.4(d)-0.6(el)5.4(,)-320.5(c)-0.8(o)10.3(m)17.6(p)9.9(u)10.5(t)-7.7(a)17.9(t)-6.8(i)-1.3(o)10.3(n)1.3(a)-6.5(l)-316.2(p)10.8(i)10.4(p)-10(e)3(line)5.7(,)]TJ
T*
-0.0016 Tc
[(a)7.4(n)1.6(d)-349.9(e)-1.2(n)6.1(g)-7(ine)-6.6(e)-1.2(r)-8.2(i)-1.9(n)6.1(g)-348.5(desig)-7(n)-350.8(t)4.4(o)-350.7(c)-1.4(o)9.7(m)17(p)9.3(u)10(t)-8.3(a)17.3(t)-7.4(i)-1.9(o)9.7(n)0.7(a)-7.1(l)-345.7(mo)-11.1(dels,)-350(w)-4.1(i)9.8(t)-8.3(h)-350.2(t)-8.3(he)]TJ
T*
-0.0189 Tc
[(ap)-8(p)-11.6(l)-18.8(i)-19.2(c)-21.4(at)-24.7(i)-19.2(o)-7.6(n)-11.2(s)-260.8(at)-262.3(m)-15.7(o)-12.1(l)-18.8(e)-23.9(c)-25.9(u)-24.5(l)-21.6(a)-9.9(r)44(,)-261.6(n)-15.7(e)-18.5(u)-19.1(r)-6.5(o)-7.6(n)-16.6(a)-24.4(l)-12.5(,)-259.8(p)-7.1(r)-6.5(o)-8.5(t)-12.9(e)-18.5(i)-19.2(n)-19.4(,)-260.7(g)-10.7(e)-18.5(n)-15.7(e)-261.5(r)-6.5(e)-18.5(g)-18.9(u)-24.5(l)-21.6(at)-12.9(o)-7.6(r)-48.1(y)]TJ
T*
-0.0015 Tc
[(net)-4.6(w)6.9(o)9.8(r)1.8(k,)-227(a)7.5(n)1.7(d)-227.8(g)6.7(ene)-228.7(o)9.8(n)17(t)4.5(olog)-25.8(y)-226.4(l)-1.4(e)-9.2(v)6.2(els.)]TJ
1.5005 -1.1419 TD
-0.0103 Tc
[()-7.1(e)-250.2(c)-10.1(o)1(m)8.3(p)-15.7(ar)-16.9(i)-7.9(s)-18.2(on)-248.3(on)-251.1(bi)-10.6(ol)-10.2(o)-10.7(g)-34.6(y)-250.5(s)-18.2(e)-15.3(q)-0.7(u)-10.5(e)-9.9(n)-7.1(c)-10.1(e)-9.9(s)-251.3(i)-7.9(s)-250.4(on)-7.1(e)-250.2(o)1(f)-250.9(t)-17(h)-6.6(e)-250.2(m)-7.1(o)-10.7(s)-4.7(t)]TJ
-1.5005 -1.141 TD
-0.0006 Tc
[(im)18(p)-9.6(o)10.7(r)-10.8(t)-7.3(a)8.4(n)17.9(t)-469.8(t)-7.3(asks)-471(in)-471.7(a)8.4(n)1.7(a)-6.1(l)6.7(yzin)7.1(g)-470.3(s)-0.4(imi)-6.3(l)-3.3(a)8.4(r)-7.2(i)10.8(t)-6.4(ies)-469.2(o)10.7(f)-471.6(f)-7.2(unc)-7.6(t)-6.4(io)10.7(n)-468.1(a)8.4(nd)]TJ
T*
-0.0002 Tc
[(p)11.6(r)12.2(o)10.2(p)-9.2(er)-10.4(t)-6(i)-0.5(es.)-298.9(W)143.3(.)-299.8(D)-6.9(en)7.5(g)-299.2(a)8.8(nd)-298.8(Y)115.3(.)-299.8(L)20.2(u)-3.1(a)8.8(n)-298.8(in)18.3(t)5.8(e)0.2(g)-5.6(r)-0.5(a)18.7(t)5.8(e)-5.2(d)-298.8(t)-6.9(h)3.5(e)-299.7(d)12(ua)-5.7(l-v)7.5(e)-5.2(c)-7.2(t)5.8(o)11.1(r)]TJ
T*
-0.0009 Tc
[(c)-7.9(u)-1.1(r)-30.1(v)6.8(e)-242.6(\()-0.9(D)15.9(V)62.5(-c)-7.9(ur)-30.1(v)6.8(e)-0.5(\))-243(a)8.1(nd)-241.7(t)-7.6(h)2.8(e)-242.6(det)-7.6(a)8.1(i)-6.6(le)-5.9(d)-241.7(h)21.8(y)7.3(d)-0.5(r)11.5(o)9.5(p)6.4(h)2.8(ob)11.1(ic-h)21.8(y)7.3(d)-0.5(r)11.5(o)9.5(p)6.4(h)-0.8(i)-6.6(l)-0.9(ic)]TJ
T*
-0.001 Tc
[(\(HP\))-574.6(mo)-10.4(del)-573.7(o)10.3(f)-573.1(a)8(mino)-573.3(acids,)-575.2(in)-574.2(t)-7.7(h)2.7(e)-573.3(r)11.4(ep)10.8(r)11.4(e)-0.6(s)-8.9(e)-0.6(n)17.5(t)-7.7(a)17.9(t)-6.8(io)10.3(n)-570.6(a)8(nd)]TJ
T*
0 Tc
[(vis)5.6(u)-2.9(a)-5.5(l)0(iza)18.9(t)-5.8(io)11.3(n)-193.8(o)11.3(f)-196.3(p)11.8(r)12.4(o)10.4(t)6(e)0.4(in)-194.7(s)-7.9(e)-5(q)9.6(u)-0.2(ences.)-196.6(Al)11.8(t)-6.7(h)3.7(o)10.4(u)-0.2(g)-7.2(h)-194.1(t)-6.7(h)3.7(e)-195.6(i)-0.3(nf)8.7(o)11.3(r)-6.6(ma)18.9(t)-5.8(i)-0.3(o)11.3(n)]TJ
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