Abstract
This thesis presents a novel model for understanding chronic wound pathology, integrating factors such as vascular aging, oxidative stress, hormonal imbalance, and neuropathology that impair skin regeneration. The thesis introduces dopamine-modified hydrogels, nanoparticle systems, and nucleic acid-functionalized materials to support targeted debridement, tissue interaction, and wound resolution. The work proposes material platforms with enhanced adhesion, magnetic responsiveness, and gene delivery potential for future clinical applications for chronic wound management.Thesis is embargoed until 31st October 2027.
| Date of Award | Oct 2025 |
|---|---|
| Original language | English |
| Supervisor | Mateus Webba Da Silva (Supervisor) & Paul McCarron (Supervisor) |
Keywords
- polyvinyl alcohol
- hydrogel
- dopamine
- natural DNA
- magnetic nanoparticles
- enzymatic debridement
- mechanical debridement
- medical foam
- exudate management
- chronic wound
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