Network medicine to explore the underlying disease mechanisms of ALS

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neuromuscular disorder and is the most common form of motor neuron disease (MND). The prognosis for an individual with ALS can vary but in general is extremely poor. Currently there is no known cure for ALS and any current drug treatment is expensive and only modestly effective. In this study, we applied network medicine approaches to try and further understand the underlying mechanisms involved in ALS. (...) This study provides a precursor to apply more concise research into ALS using network analysis tools, particularly as the coverage and quality of MINs improves.

Thesis embargoed until 31 August 2027.

Date of Award	Aug 2025
Original language	English
Sponsors	Department for the Economy
Supervisor	William Duddy (Supervisor) & Stephanie Marie Duguez (Supervisor)