Investigation of oral microbiome shifts in patients with psychiatric disorders

Abstract

This study investigates the role of the oral microbiome in the psychiatric disorders depression and schizophrenia, both of which are increasing globally and have complex, multifactorial causes. While traditionally research has focused on the gut-brain axis, this thesis explores the oral microbiome using 16S rRNA sequencing to identify microbial differences in individuals with these disorders compared to healthy controls.  The study highlights the distinct and overlapping microbial and inflammatory profiles in depression and schizophrenia, suggesting that oral microbiome analysis could support future diagnostic tools and deepen understanding of psychiatric pathophysiology.

Thesis is embargoed until 31st October 2027

Date of Award	Oct 2025
Original language	English
Sponsors	Department for the Economy
Supervisor	Coral Lapsley (Supervisor), Elaine Murray (Supervisor) & Andrew McDowell (Supervisor)