Abstract
Surgical site infections (SSIs) following fracture repair pose significant clinical challenges, delaying healing and increasing healthcare costs. Systemic antibiotics often fail to reach therapeutic bone concentrations and contribute to antimicrobial resistance (AMR). This study presents a dual-function strategy using carbohydrate-primed bioactive glass (BG) scaffolds to support bone regeneration while delivering localized antibiotics.Thesis is embargoed until 31st October 2027
| Date of Award | Oct 2025 |
|---|---|
| Original language | English |
| Supervisor | Deborah Lowry (Supervisor), Heather Coleman (Supervisor) & Aaron Courtenay (Supervisor) |
Keywords
- bioglass 45S5
- antibiotic delivery
- orthopaedic infections
- staphylococcus aureus
- antimicrobial resistance
- osteogenic potential
- MRSA
- surgical site infections
- orthopaedic surgeries