ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas

Annelies Wilder-smith, Raman Preet, Elizabeth B. Brickley, Ricardo Arraes De Alencar Ximenes, Demócrito De Barros Miranda-filho, Celina Maria Turchi Martelli, Thália Velho Barreto De Araújo, Ulisses Ramos Montarroyos, Maria Elisabeth Moreira, Marília Dalva Turchi, Tom Solomon, Bart C. Jacobs, Carlos Pardo Villamizar, Lyda Osorio, Ana Maria Bispo De Filipps, Johan Neyts, Suzanne Kaptein, Ralph Huits, Kevin K. Ariën, Hugh J. Willison & 26 others Julia M. Edgar, Susan C. Barnett, Rosanna Peeling, Debi Boeras, Maria G. Guzman, Aravinda M. De Silva, Andrew K. Falconar, Claudia Romero-vivas, Michael W. Gaunt, Alessandro Sette, Daniela Weiskopf, Louis Lambrechts, Helen Dolk, Joan K. Morris, Ieda M. Orioli, Kathleen M. O’reilly, Laith Yakob, Joacim Rocklöv, Cristiane Soares, Maria Lúcia Brito Ferreira, Rafael Freitas De Oliveira Franca, Alexander R. Precioso, James Logan, Trudie Lang, Nina Jamieson, Eduardo Massad

Research output: Contribution to journalArticle

Abstract

Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults.
For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. Through the Butantan Phase 3 dengue vaccine trial, we have access to samples of 17,000 subjects in 14 different geographic locations in Brazil. To address the lack of access to clinical samples for diagnostic evaluation, ZikaPLAN set up a network of quality sites with access to well-characterized clinical specimens and capacity for independent evaluations. The International Committee for Congenital Anomaly Surveillance Tools was formed with global representation from regional networks conducting birth defects surveillance. We have collated a comprehensive inventory of resources and tools for birth defects surveillance, and developed an App for low resource regions facilitating the coding and description of all major externally visible congenital anomalies including congenital Zika syndrome. Research Capacity Network (REDe) is a shared and open resource centre where researchers and health workers can access tools, resources and support, enabling better and more research in the region.
Addressing the gap in research capacity in LMICs is pivotal in ensuring broad-based systems to be prepared for the next outbreak. Our shared and open research space through REDe will be used to maximize the transfer of research into practice by summarizing the research output and by hosting the tools, resources, guidance and recommendations generated by these studies. Leveraging on the research from this consortium, we are working towards a research preparedness network.
LanguageEnglish
Article number1666566
Pages1-18
Number of pages18
JournalGlobal Health Action
Volume12
Issue number1
Early online date23 Oct 2019
DOIs
Publication statusPublished - 10 Dec 2019

Fingerprint

Research
Dengue Vaccines
Entomology
Capacity Building
Geographic Locations
Virology
Colombia
Disease Outbreaks
Brazil
Pregnant Women
Cohort Studies
Research Personnel
Newborn Infant
Equipment and Supplies
Health
Infection

Keywords

  • Zika
  • Congenital Zika Syndrome
  • birth defect
  • epidemic preparedness
  • research capacity building
  • European Commision
  • microcephaly
  • encephalitis
  • sustainability
  • congenital Zika syndrome
  • European Commission
  • Guillain-Barré syndrome
  • Guillain-Barr? syndrome

Cite this

Wilder-smith, A., Preet, R., Brickley, E. B., Ximenes, R. A. D. A., Miranda-filho, D. D. B., Turchi Martelli, C. M., ... Massad, E. (2019). ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. Global Health Action, 12(1), 1-18. [1666566]. https://doi.org/10.1080/16549716.2019.1666566
Wilder-smith, Annelies ; Preet, Raman ; Brickley, Elizabeth B. ; Ximenes, Ricardo Arraes De Alencar ; Miranda-filho, Demócrito De Barros ; Turchi Martelli, Celina Maria ; Araújo, Thália Velho Barreto De ; Montarroyos, Ulisses Ramos ; Moreira, Maria Elisabeth ; Turchi, Marília Dalva ; Solomon, Tom ; Jacobs, Bart C. ; Villamizar, Carlos Pardo ; Osorio, Lyda ; De Filipps, Ana Maria Bispo ; Neyts, Johan ; Kaptein, Suzanne ; Huits, Ralph ; Ariën, Kevin K. ; Willison, Hugh J. ; Edgar, Julia M. ; Barnett, Susan C. ; Peeling, Rosanna ; Boeras, Debi ; Guzman, Maria G. ; De Silva, Aravinda M. ; Falconar, Andrew K. ; Romero-vivas, Claudia ; Gaunt, Michael W. ; Sette, Alessandro ; Weiskopf, Daniela ; Lambrechts, Louis ; Dolk, Helen ; Morris, Joan K. ; Orioli, Ieda M. ; O’reilly, Kathleen M. ; Yakob, Laith ; Rocklöv, Joacim ; Soares, Cristiane ; Ferreira, Maria Lúcia Brito ; Franca, Rafael Freitas De Oliveira ; Precioso, Alexander R. ; Logan, James ; Lang, Trudie ; Jamieson, Nina ; Massad, Eduardo. / ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. In: Global Health Action. 2019 ; Vol. 12, No. 1. pp. 1-18.
@article{1cfd1f81b58847f0826a2c41c3ac5555,
title = "ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas",
abstract = "Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults. For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. Through the Butantan Phase 3 dengue vaccine trial, we have access to samples of 17,000 subjects in 14 different geographic locations in Brazil. To address the lack of access to clinical samples for diagnostic evaluation, ZikaPLAN set up a network of quality sites with access to well-characterized clinical specimens and capacity for independent evaluations. The International Committee for Congenital Anomaly Surveillance Tools was formed with global representation from regional networks conducting birth defects surveillance. We have collated a comprehensive inventory of resources and tools for birth defects surveillance, and developed an App for low resource regions facilitating the coding and description of all major externally visible congenital anomalies including congenital Zika syndrome. Research Capacity Network (REDe) is a shared and open resource centre where researchers and health workers can access tools, resources and support, enabling better and more research in the region. Addressing the gap in research capacity in LMICs is pivotal in ensuring broad-based systems to be prepared for the next outbreak. Our shared and open research space through REDe will be used to maximize the transfer of research into practice by summarizing the research output and by hosting the tools, resources, guidance and recommendations generated by these studies. Leveraging on the research from this consortium, we are working towards a research preparedness network.",
keywords = "Zika, Congenital Zika Syndrome, birth defect, epidemic preparedness, research capacity building, European Commision, microcephaly, encephalitis, sustainability, congenital Zika syndrome, European Commission, Guillain-Barr{\'e} syndrome, Guillain-Barr? syndrome",
author = "Annelies Wilder-smith and Raman Preet and Brickley, {Elizabeth B.} and Ximenes, {Ricardo Arraes De Alencar} and Miranda-filho, {Dem{\'o}crito De Barros} and {Turchi Martelli}, {Celina Maria} and Ara{\'u}jo, {Th{\'a}lia Velho Barreto De} and Montarroyos, {Ulisses Ramos} and Moreira, {Maria Elisabeth} and Turchi, {Mar{\'i}lia Dalva} and Tom Solomon and Jacobs, {Bart C.} and Villamizar, {Carlos Pardo} and Lyda Osorio and {De Filipps}, {Ana Maria Bispo} and Johan Neyts and Suzanne Kaptein and Ralph Huits and Ari{\"e}n, {Kevin K.} and Willison, {Hugh J.} and Edgar, {Julia M.} and Barnett, {Susan C.} and Rosanna Peeling and Debi Boeras and Guzman, {Maria G.} and {De Silva}, {Aravinda M.} and Falconar, {Andrew K.} and Claudia Romero-vivas and Gaunt, {Michael W.} and Alessandro Sette and Daniela Weiskopf and Louis Lambrechts and Helen Dolk and Morris, {Joan K.} and Orioli, {Ieda M.} and O’reilly, {Kathleen M.} and Laith Yakob and Joacim Rockl{\"o}v and Cristiane Soares and Ferreira, {Maria L{\'u}cia Brito} and Franca, {Rafael Freitas De Oliveira} and Precioso, {Alexander R.} and James Logan and Trudie Lang and Nina Jamieson and Eduardo Massad",
year = "2019",
month = "12",
day = "10",
doi = "10.1080/16549716.2019.1666566",
language = "English",
volume = "12",
pages = "1--18",
journal = "Global Health Action",
issn = "1654-9880",
number = "1",

}

Wilder-smith, A, Preet, R, Brickley, EB, Ximenes, RADA, Miranda-filho, DDB, Turchi Martelli, CM, Araújo, TVBD, Montarroyos, UR, Moreira, ME, Turchi, MD, Solomon, T, Jacobs, BC, Villamizar, CP, Osorio, L, De Filipps, AMB, Neyts, J, Kaptein, S, Huits, R, Ariën, KK, Willison, HJ, Edgar, JM, Barnett, SC, Peeling, R, Boeras, D, Guzman, MG, De Silva, AM, Falconar, AK, Romero-vivas, C, Gaunt, MW, Sette, A, Weiskopf, D, Lambrechts, L, Dolk, H, Morris, JK, Orioli, IM, O’reilly, KM, Yakob, L, Rocklöv, J, Soares, C, Ferreira, MLB, Franca, RFDO, Precioso, AR, Logan, J, Lang, T, Jamieson, N & Massad, E 2019, 'ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas', Global Health Action, vol. 12, no. 1, 1666566, pp. 1-18. https://doi.org/10.1080/16549716.2019.1666566

ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. / Wilder-smith, Annelies; Preet, Raman; Brickley, Elizabeth B.; Ximenes, Ricardo Arraes De Alencar; Miranda-filho, Demócrito De Barros; Turchi Martelli, Celina Maria; Araújo, Thália Velho Barreto De; Montarroyos, Ulisses Ramos; Moreira, Maria Elisabeth; Turchi, Marília Dalva; Solomon, Tom; Jacobs, Bart C.; Villamizar, Carlos Pardo; Osorio, Lyda; De Filipps, Ana Maria Bispo; Neyts, Johan; Kaptein, Suzanne; Huits, Ralph; Ariën, Kevin K.; Willison, Hugh J.; Edgar, Julia M.; Barnett, Susan C.; Peeling, Rosanna; Boeras, Debi; Guzman, Maria G.; De Silva, Aravinda M.; Falconar, Andrew K.; Romero-vivas, Claudia; Gaunt, Michael W.; Sette, Alessandro; Weiskopf, Daniela; Lambrechts, Louis; Dolk, Helen; Morris, Joan K.; Orioli, Ieda M.; O’reilly, Kathleen M.; Yakob, Laith; Rocklöv, Joacim; Soares, Cristiane; Ferreira, Maria Lúcia Brito; Franca, Rafael Freitas De Oliveira; Precioso, Alexander R.; Logan, James; Lang, Trudie; Jamieson, Nina; Massad, Eduardo.

In: Global Health Action, Vol. 12, No. 1, 1666566, 10.12.2019, p. 1-18.

Research output: Contribution to journalArticle

TY - JOUR

T1 - ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas

AU - Wilder-smith, Annelies

AU - Preet, Raman

AU - Brickley, Elizabeth B.

AU - Ximenes, Ricardo Arraes De Alencar

AU - Miranda-filho, Demócrito De Barros

AU - Turchi Martelli, Celina Maria

AU - Araújo, Thália Velho Barreto De

AU - Montarroyos, Ulisses Ramos

AU - Moreira, Maria Elisabeth

AU - Turchi, Marília Dalva

AU - Solomon, Tom

AU - Jacobs, Bart C.

AU - Villamizar, Carlos Pardo

AU - Osorio, Lyda

AU - De Filipps, Ana Maria Bispo

AU - Neyts, Johan

AU - Kaptein, Suzanne

AU - Huits, Ralph

AU - Ariën, Kevin K.

AU - Willison, Hugh J.

AU - Edgar, Julia M.

AU - Barnett, Susan C.

AU - Peeling, Rosanna

AU - Boeras, Debi

AU - Guzman, Maria G.

AU - De Silva, Aravinda M.

AU - Falconar, Andrew K.

AU - Romero-vivas, Claudia

AU - Gaunt, Michael W.

AU - Sette, Alessandro

AU - Weiskopf, Daniela

AU - Lambrechts, Louis

AU - Dolk, Helen

AU - Morris, Joan K.

AU - Orioli, Ieda M.

AU - O’reilly, Kathleen M.

AU - Yakob, Laith

AU - Rocklöv, Joacim

AU - Soares, Cristiane

AU - Ferreira, Maria Lúcia Brito

AU - Franca, Rafael Freitas De Oliveira

AU - Precioso, Alexander R.

AU - Logan, James

AU - Lang, Trudie

AU - Jamieson, Nina

AU - Massad, Eduardo

PY - 2019/12/10

Y1 - 2019/12/10

N2 - Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults. For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. Through the Butantan Phase 3 dengue vaccine trial, we have access to samples of 17,000 subjects in 14 different geographic locations in Brazil. To address the lack of access to clinical samples for diagnostic evaluation, ZikaPLAN set up a network of quality sites with access to well-characterized clinical specimens and capacity for independent evaluations. The International Committee for Congenital Anomaly Surveillance Tools was formed with global representation from regional networks conducting birth defects surveillance. We have collated a comprehensive inventory of resources and tools for birth defects surveillance, and developed an App for low resource regions facilitating the coding and description of all major externally visible congenital anomalies including congenital Zika syndrome. Research Capacity Network (REDe) is a shared and open resource centre where researchers and health workers can access tools, resources and support, enabling better and more research in the region. Addressing the gap in research capacity in LMICs is pivotal in ensuring broad-based systems to be prepared for the next outbreak. Our shared and open research space through REDe will be used to maximize the transfer of research into practice by summarizing the research output and by hosting the tools, resources, guidance and recommendations generated by these studies. Leveraging on the research from this consortium, we are working towards a research preparedness network.

AB - Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults. For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. Through the Butantan Phase 3 dengue vaccine trial, we have access to samples of 17,000 subjects in 14 different geographic locations in Brazil. To address the lack of access to clinical samples for diagnostic evaluation, ZikaPLAN set up a network of quality sites with access to well-characterized clinical specimens and capacity for independent evaluations. The International Committee for Congenital Anomaly Surveillance Tools was formed with global representation from regional networks conducting birth defects surveillance. We have collated a comprehensive inventory of resources and tools for birth defects surveillance, and developed an App for low resource regions facilitating the coding and description of all major externally visible congenital anomalies including congenital Zika syndrome. Research Capacity Network (REDe) is a shared and open resource centre where researchers and health workers can access tools, resources and support, enabling better and more research in the region. Addressing the gap in research capacity in LMICs is pivotal in ensuring broad-based systems to be prepared for the next outbreak. Our shared and open research space through REDe will be used to maximize the transfer of research into practice by summarizing the research output and by hosting the tools, resources, guidance and recommendations generated by these studies. Leveraging on the research from this consortium, we are working towards a research preparedness network.

KW - Zika

KW - Congenital Zika Syndrome

KW - birth defect

KW - epidemic preparedness

KW - research capacity building

KW - European Commision

KW - microcephaly

KW - encephalitis

KW - sustainability

KW - congenital Zika syndrome

KW - European Commission

KW - Guillain-Barré syndrome

KW - Guillain-Barr? syndrome

UR - http://www.scopus.com/inward/record.url?scp=85073726043&partnerID=8YFLogxK

U2 - 10.1080/16549716.2019.1666566

DO - 10.1080/16549716.2019.1666566

M3 - Article

VL - 12

SP - 1

EP - 18

JO - Global Health Action

T2 - Global Health Action

JF - Global Health Action

SN - 1654-9880

IS - 1

M1 - 1666566

ER -

Wilder-smith A, Preet R, Brickley EB, Ximenes RADA, Miranda-filho DDB, Turchi Martelli CM et al. ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. Global Health Action. 2019 Dec 10;12(1):1-18. 1666566. https://doi.org/10.1080/16549716.2019.1666566