Which drugs cause treatment-related problems? Analysis of 10,672 problems within the outpatient setting.

Ghaith Al-Taani, Sayer Al-Azzam, Karem Alzoubi, Mamoon Aldeyab

Research output: Contribution to journalArticle

Abstract

BACKGROUND:
Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists' efforts to patients that are at high risk for TRPs.

OBJECTIVES:
The present study aimed to identify medications most commonly associated with TRPs.

SETTING:
Outpatient departments of five public and teaching hospitals in Jordan.

METHOD:
TRPs and drugs most commonly implicated with TRPs were assessed for patients recruited from outpatient clinics in five major hospitals in Jordan using a standardized and validated pharmaceutical care manual.

MAIN OUTCOME MEASURE:
Drugs associated with different types of TRPs.

RESULTS:
Ultimately, 2,747 patients, with a total of 10,672 TRPs, were included in the study. The medication groups most commonly associated with TRPs were cardiovascular (53.0%), endocrine (18.1%), and gastrointestinal (7.7%) drugs. The most common specific drugs associated with TRPs from any category were atorvastatin (12.5%), metformin (8.5%), simvastatin (6.2%), and enalapril (5.9%). Cardiovascular medications were the most common drugs implicated with multiple subtypes of TRPs - most commonly, allergic reaction or undesirable effect (88.5%), drug product not available (87.3%), safety interaction issues (81.8%), a need for additional or more frequent monitoring (78.0%), and more effective drugs available (77.2%). Hypertension, diabetes mellitus, and dyslipidemia were the most common diseases associated with different subtypes of TRPs.

CONCLUSION:
The present study identified high-risk drugs for TRPs, which can be used as identification of targeting approach TRPs. Such an approach would improve care provided to patients and can inform health care policies.
LanguageEnglish
Pages2273-2281
JournalTherapeutics and Clinical Risk Management
Volume14
DOIs
Publication statusPublished - 16 Nov 2018

Fingerprint

Outpatients
Pharmaceutical Preparations
Therapeutics
Jordan
Delivery of Health Care
Gastrointestinal Agents
Pharmaceutical Services
Enalapril
Simvastatin
Metformin
Public Hospitals
Dyslipidemias
Health Policy
Ambulatory Care Facilities
Pharmacists
Teaching Hospitals
Diabetes Mellitus
Hypersensitivity
Hypertension
Safety

Keywords

  • drug related problems
  • drug therapy problems
  • high alert medication
  • Jordan
  • treatment related problems
  • pharmaceutical care

Cite this

Al-Taani, Ghaith ; Al-Azzam, Sayer ; Alzoubi, Karem ; Aldeyab, Mamoon. / Which drugs cause treatment-related problems? Analysis of 10,672 problems within the outpatient setting. In: Therapeutics and Clinical Risk Management. 2018 ; Vol. 14. pp. 2273-2281.
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abstract = "BACKGROUND:Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists' efforts to patients that are at high risk for TRPs.OBJECTIVES:The present study aimed to identify medications most commonly associated with TRPs.SETTING:Outpatient departments of five public and teaching hospitals in Jordan.METHOD:TRPs and drugs most commonly implicated with TRPs were assessed for patients recruited from outpatient clinics in five major hospitals in Jordan using a standardized and validated pharmaceutical care manual.MAIN OUTCOME MEASURE:Drugs associated with different types of TRPs.RESULTS:Ultimately, 2,747 patients, with a total of 10,672 TRPs, were included in the study. The medication groups most commonly associated with TRPs were cardiovascular (53.0{\%}), endocrine (18.1{\%}), and gastrointestinal (7.7{\%}) drugs. The most common specific drugs associated with TRPs from any category were atorvastatin (12.5{\%}), metformin (8.5{\%}), simvastatin (6.2{\%}), and enalapril (5.9{\%}). Cardiovascular medications were the most common drugs implicated with multiple subtypes of TRPs - most commonly, allergic reaction or undesirable effect (88.5{\%}), drug product not available (87.3{\%}), safety interaction issues (81.8{\%}), a need for additional or more frequent monitoring (78.0{\%}), and more effective drugs available (77.2{\%}). Hypertension, diabetes mellitus, and dyslipidemia were the most common diseases associated with different subtypes of TRPs.CONCLUSION:The present study identified high-risk drugs for TRPs, which can be used as identification of targeting approach TRPs. Such an approach would improve care provided to patients and can inform health care policies.",
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Which drugs cause treatment-related problems? Analysis of 10,672 problems within the outpatient setting. / Al-Taani, Ghaith; Al-Azzam, Sayer; Alzoubi, Karem; Aldeyab, Mamoon.

In: Therapeutics and Clinical Risk Management, Vol. 14, 16.11.2018, p. 2273-2281.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Which drugs cause treatment-related problems? Analysis of 10,672 problems within the outpatient setting.

AU - Al-Taani, Ghaith

AU - Al-Azzam, Sayer

AU - Alzoubi, Karem

AU - Aldeyab, Mamoon

PY - 2018/11/16

Y1 - 2018/11/16

N2 - BACKGROUND:Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists' efforts to patients that are at high risk for TRPs.OBJECTIVES:The present study aimed to identify medications most commonly associated with TRPs.SETTING:Outpatient departments of five public and teaching hospitals in Jordan.METHOD:TRPs and drugs most commonly implicated with TRPs were assessed for patients recruited from outpatient clinics in five major hospitals in Jordan using a standardized and validated pharmaceutical care manual.MAIN OUTCOME MEASURE:Drugs associated with different types of TRPs.RESULTS:Ultimately, 2,747 patients, with a total of 10,672 TRPs, were included in the study. The medication groups most commonly associated with TRPs were cardiovascular (53.0%), endocrine (18.1%), and gastrointestinal (7.7%) drugs. The most common specific drugs associated with TRPs from any category were atorvastatin (12.5%), metformin (8.5%), simvastatin (6.2%), and enalapril (5.9%). Cardiovascular medications were the most common drugs implicated with multiple subtypes of TRPs - most commonly, allergic reaction or undesirable effect (88.5%), drug product not available (87.3%), safety interaction issues (81.8%), a need for additional or more frequent monitoring (78.0%), and more effective drugs available (77.2%). Hypertension, diabetes mellitus, and dyslipidemia were the most common diseases associated with different subtypes of TRPs.CONCLUSION:The present study identified high-risk drugs for TRPs, which can be used as identification of targeting approach TRPs. Such an approach would improve care provided to patients and can inform health care policies.

AB - BACKGROUND:Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists' efforts to patients that are at high risk for TRPs.OBJECTIVES:The present study aimed to identify medications most commonly associated with TRPs.SETTING:Outpatient departments of five public and teaching hospitals in Jordan.METHOD:TRPs and drugs most commonly implicated with TRPs were assessed for patients recruited from outpatient clinics in five major hospitals in Jordan using a standardized and validated pharmaceutical care manual.MAIN OUTCOME MEASURE:Drugs associated with different types of TRPs.RESULTS:Ultimately, 2,747 patients, with a total of 10,672 TRPs, were included in the study. The medication groups most commonly associated with TRPs were cardiovascular (53.0%), endocrine (18.1%), and gastrointestinal (7.7%) drugs. The most common specific drugs associated with TRPs from any category were atorvastatin (12.5%), metformin (8.5%), simvastatin (6.2%), and enalapril (5.9%). Cardiovascular medications were the most common drugs implicated with multiple subtypes of TRPs - most commonly, allergic reaction or undesirable effect (88.5%), drug product not available (87.3%), safety interaction issues (81.8%), a need for additional or more frequent monitoring (78.0%), and more effective drugs available (77.2%). Hypertension, diabetes mellitus, and dyslipidemia were the most common diseases associated with different subtypes of TRPs.CONCLUSION:The present study identified high-risk drugs for TRPs, which can be used as identification of targeting approach TRPs. Such an approach would improve care provided to patients and can inform health care policies.

KW - drug related problems

KW - drug therapy problems

KW - high alert medication

KW - Jordan

KW - treatment related problems

KW - pharmaceutical care

U2 - 10.2147/TCRM.S180747

DO - 10.2147/TCRM.S180747

M3 - Article

VL - 14

SP - 2273

EP - 2281

JO - Therapeutics and Clinical Risk Management

T2 - Therapeutics and Clinical Risk Management

JF - Therapeutics and Clinical Risk Management

SN - 1178-203X

ER -