Water soluble quantum dots as hydrophilic carriers and two-photon excitedenergy donors in photodynamic therapy

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Abstract

In search of strategies to develop deeply penetrating agents for use in Photodynamic Therapy (PDT),we have devised a Quantum Dot-Rose Bengal conjugate that is effective at producing singlet oxygenupon two-photon irradiation. The CdSe/ZnS Quantum Dot, with its high two photon absorption crosssection, serves as a two-photon absorbing antenna and transfers its excited state energy to the attachedphotosensitiser which engages with molecular oxygen to produce cytotoxic singlet oxygen. Thus, wewere able to excite the photosensitiser indirectly, which has an absorption maximum of 565 nm, withtwo-photon irradiation at 800 nm. Given the tissue penetration depth of 800 nm light is at least fourtimes greater than 565 nm light, this offers the opportunity to access much deeper-seated tumours thanis currently possible with pharmaceutically approved photosensitisers. Furthermore, the attachment ofthe photosensitiser to the hydrophilic quantum dot improved the aqueous solubility of thephotosensitiser by 48 fold, thus overcoming another limitation of currently used photosensitisers, thatof poor aqueous solubility.
LanguageEnglish
Pages6456-6462
JournalJournal of Materials Chemistry
Volume22
Issue number13
DOIs
Publication statusPublished - 17 Feb 2012

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Photodynamic therapy
Photosensitizing Agents
Semiconductor quantum dots
Photons
Water
Solubility
Irradiation
Rose Bengal
Singlet Oxygen
Molecular oxygen
Excited states
Tumors
Tissue
Antennas

Cite this

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title = "Water soluble quantum dots as hydrophilic carriers and two-photon excitedenergy donors in photodynamic therapy",
abstract = "In search of strategies to develop deeply penetrating agents for use in Photodynamic Therapy (PDT),we have devised a Quantum Dot-Rose Bengal conjugate that is effective at producing singlet oxygenupon two-photon irradiation. The CdSe/ZnS Quantum Dot, with its high two photon absorption crosssection, serves as a two-photon absorbing antenna and transfers its excited state energy to the attachedphotosensitiser which engages with molecular oxygen to produce cytotoxic singlet oxygen. Thus, wewere able to excite the photosensitiser indirectly, which has an absorption maximum of 565 nm, withtwo-photon irradiation at 800 nm. Given the tissue penetration depth of 800 nm light is at least fourtimes greater than 565 nm light, this offers the opportunity to access much deeper-seated tumours thanis currently possible with pharmaceutically approved photosensitisers. Furthermore, the attachment ofthe photosensitiser to the hydrophilic quantum dot improved the aqueous solubility of thephotosensitiser by 48 fold, thus overcoming another limitation of currently used photosensitisers, thatof poor aqueous solubility.",
author = "Colin Fowley and Nikolitsa Nomikou and McHale, {Anthony P.} and Paul McCarron and Bridgeen McCaughan and John Callan",
year = "2012",
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doi = "10.1039/c2jm00096b",
language = "English",
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journal = "Journal of Materials Chemistry",
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TY - JOUR

T1 - Water soluble quantum dots as hydrophilic carriers and two-photon excitedenergy donors in photodynamic therapy

AU - Fowley, Colin

AU - Nomikou, Nikolitsa

AU - McHale, Anthony P.

AU - McCarron, Paul

AU - McCaughan, Bridgeen

AU - Callan, John

PY - 2012/2/17

Y1 - 2012/2/17

N2 - In search of strategies to develop deeply penetrating agents for use in Photodynamic Therapy (PDT),we have devised a Quantum Dot-Rose Bengal conjugate that is effective at producing singlet oxygenupon two-photon irradiation. The CdSe/ZnS Quantum Dot, with its high two photon absorption crosssection, serves as a two-photon absorbing antenna and transfers its excited state energy to the attachedphotosensitiser which engages with molecular oxygen to produce cytotoxic singlet oxygen. Thus, wewere able to excite the photosensitiser indirectly, which has an absorption maximum of 565 nm, withtwo-photon irradiation at 800 nm. Given the tissue penetration depth of 800 nm light is at least fourtimes greater than 565 nm light, this offers the opportunity to access much deeper-seated tumours thanis currently possible with pharmaceutically approved photosensitisers. Furthermore, the attachment ofthe photosensitiser to the hydrophilic quantum dot improved the aqueous solubility of thephotosensitiser by 48 fold, thus overcoming another limitation of currently used photosensitisers, thatof poor aqueous solubility.

AB - In search of strategies to develop deeply penetrating agents for use in Photodynamic Therapy (PDT),we have devised a Quantum Dot-Rose Bengal conjugate that is effective at producing singlet oxygenupon two-photon irradiation. The CdSe/ZnS Quantum Dot, with its high two photon absorption crosssection, serves as a two-photon absorbing antenna and transfers its excited state energy to the attachedphotosensitiser which engages with molecular oxygen to produce cytotoxic singlet oxygen. Thus, wewere able to excite the photosensitiser indirectly, which has an absorption maximum of 565 nm, withtwo-photon irradiation at 800 nm. Given the tissue penetration depth of 800 nm light is at least fourtimes greater than 565 nm light, this offers the opportunity to access much deeper-seated tumours thanis currently possible with pharmaceutically approved photosensitisers. Furthermore, the attachment ofthe photosensitiser to the hydrophilic quantum dot improved the aqueous solubility of thephotosensitiser by 48 fold, thus overcoming another limitation of currently used photosensitisers, thatof poor aqueous solubility.

U2 - 10.1039/c2jm00096b

DO - 10.1039/c2jm00096b

M3 - Article

VL - 22

SP - 6456

EP - 6462

JO - Journal of Materials Chemistry

T2 - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

SN - 0959-9428

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ER -