Volume reduction of the corpus callosum and its relationship with deficits in interhemispheric transfer of information in recent-onset psychosis.

Tiffany M Chaim, Maristela S Schaufelberger, Luiz K Ferreira, Fábio L S Duran, Adriana M Ayres, Marcia Scazufca, Paulo R Menezes, Edson Amaro, Claudia C Leite, Robin M Murray, Philip K McGuire, Teresa M Rushe, Geraldo F Busatto

    Research output: Contribution to journalArticle

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    Abstract

    The present study aimed to investigate the presence of corpus callosum (CC) volume deficits in a population-based recent-onset psychosis (ROP) sample, and whether CC volume relates to interhemispheric communication deficits. For this purpose, we used voxel-based morphometry comparisons of magnetic resonance imaging data between ROP (n =122) and healthy control (n = 94) subjects. Subgroups (38 ROP and 39 controls) were investigated for correlations between CC volumes and performance on the Crossed Finger Localization Test (CFLT). Significant CC volume reductions in ROP subjects versus controls emerged after excluding substance misuse and non-right-handedness. CC reductions retained significance in the schizophrenia subgroup but not in affective psychoses subjects. There were significant positive correlations between CC volumes and CFLT scores in ROP subjects, specifically in subtasks involving interhemispheric communication. From these results, we can conclude that CC volume reductions are present in association with ROP. The relationship between such deficits and CFLT performance suggests that interhemispheric communication impairments are directly linked to CC abnormalities in ROP.
    LanguageEnglish
    Pages1-9
    JournalPsychiatry research
    Volume184
    Issue number1
    Publication statusPublished - 2010

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    Corpus Callosum
    Psychotic Disorders
    Fingers
    Communication
    Psychotic Affective Disorders
    Functional Laterality
    Schizophrenia
    Magnetic Resonance Imaging

    Cite this

    Chaim, T. M., Schaufelberger, M. S., Ferreira, L. K., Duran, F. L. S., Ayres, A. M., Scazufca, M., ... Busatto, G. F. (2010). Volume reduction of the corpus callosum and its relationship with deficits in interhemispheric transfer of information in recent-onset psychosis. Psychiatry research, 184(1), 1-9.
    Chaim, Tiffany M ; Schaufelberger, Maristela S ; Ferreira, Luiz K ; Duran, Fábio L S ; Ayres, Adriana M ; Scazufca, Marcia ; Menezes, Paulo R ; Amaro, Edson ; Leite, Claudia C ; Murray, Robin M ; McGuire, Philip K ; Rushe, Teresa M ; Busatto, Geraldo F. / Volume reduction of the corpus callosum and its relationship with deficits in interhemispheric transfer of information in recent-onset psychosis. In: Psychiatry research. 2010 ; Vol. 184, No. 1. pp. 1-9.
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    title = "Volume reduction of the corpus callosum and its relationship with deficits in interhemispheric transfer of information in recent-onset psychosis.",
    abstract = "The present study aimed to investigate the presence of corpus callosum (CC) volume deficits in a population-based recent-onset psychosis (ROP) sample, and whether CC volume relates to interhemispheric communication deficits. For this purpose, we used voxel-based morphometry comparisons of magnetic resonance imaging data between ROP (n =122) and healthy control (n = 94) subjects. Subgroups (38 ROP and 39 controls) were investigated for correlations between CC volumes and performance on the Crossed Finger Localization Test (CFLT). Significant CC volume reductions in ROP subjects versus controls emerged after excluding substance misuse and non-right-handedness. CC reductions retained significance in the schizophrenia subgroup but not in affective psychoses subjects. There were significant positive correlations between CC volumes and CFLT scores in ROP subjects, specifically in subtasks involving interhemispheric communication. From these results, we can conclude that CC volume reductions are present in association with ROP. The relationship between such deficits and CFLT performance suggests that interhemispheric communication impairments are directly linked to CC abnormalities in ROP.",
    author = "Chaim, {Tiffany M} and Schaufelberger, {Maristela S} and Ferreira, {Luiz K} and Duran, {F{\'a}bio L S} and Ayres, {Adriana M} and Marcia Scazufca and Menezes, {Paulo R} and Edson Amaro and Leite, {Claudia C} and Murray, {Robin M} and McGuire, {Philip K} and Rushe, {Teresa M} and Busatto, {Geraldo F}",
    year = "2010",
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    Chaim, TM, Schaufelberger, MS, Ferreira, LK, Duran, FLS, Ayres, AM, Scazufca, M, Menezes, PR, Amaro, E, Leite, CC, Murray, RM, McGuire, PK, Rushe, TM & Busatto, GF 2010, 'Volume reduction of the corpus callosum and its relationship with deficits in interhemispheric transfer of information in recent-onset psychosis.', Psychiatry research, vol. 184, no. 1, pp. 1-9.

    Volume reduction of the corpus callosum and its relationship with deficits in interhemispheric transfer of information in recent-onset psychosis. / Chaim, Tiffany M; Schaufelberger, Maristela S; Ferreira, Luiz K; Duran, Fábio L S; Ayres, Adriana M; Scazufca, Marcia; Menezes, Paulo R; Amaro, Edson; Leite, Claudia C; Murray, Robin M; McGuire, Philip K; Rushe, Teresa M; Busatto, Geraldo F.

    In: Psychiatry research, Vol. 184, No. 1, 2010, p. 1-9.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Volume reduction of the corpus callosum and its relationship with deficits in interhemispheric transfer of information in recent-onset psychosis.

    AU - Chaim, Tiffany M

    AU - Schaufelberger, Maristela S

    AU - Ferreira, Luiz K

    AU - Duran, Fábio L S

    AU - Ayres, Adriana M

    AU - Scazufca, Marcia

    AU - Menezes, Paulo R

    AU - Amaro, Edson

    AU - Leite, Claudia C

    AU - Murray, Robin M

    AU - McGuire, Philip K

    AU - Rushe, Teresa M

    AU - Busatto, Geraldo F

    PY - 2010

    Y1 - 2010

    N2 - The present study aimed to investigate the presence of corpus callosum (CC) volume deficits in a population-based recent-onset psychosis (ROP) sample, and whether CC volume relates to interhemispheric communication deficits. For this purpose, we used voxel-based morphometry comparisons of magnetic resonance imaging data between ROP (n =122) and healthy control (n = 94) subjects. Subgroups (38 ROP and 39 controls) were investigated for correlations between CC volumes and performance on the Crossed Finger Localization Test (CFLT). Significant CC volume reductions in ROP subjects versus controls emerged after excluding substance misuse and non-right-handedness. CC reductions retained significance in the schizophrenia subgroup but not in affective psychoses subjects. There were significant positive correlations between CC volumes and CFLT scores in ROP subjects, specifically in subtasks involving interhemispheric communication. From these results, we can conclude that CC volume reductions are present in association with ROP. The relationship between such deficits and CFLT performance suggests that interhemispheric communication impairments are directly linked to CC abnormalities in ROP.

    AB - The present study aimed to investigate the presence of corpus callosum (CC) volume deficits in a population-based recent-onset psychosis (ROP) sample, and whether CC volume relates to interhemispheric communication deficits. For this purpose, we used voxel-based morphometry comparisons of magnetic resonance imaging data between ROP (n =122) and healthy control (n = 94) subjects. Subgroups (38 ROP and 39 controls) were investigated for correlations between CC volumes and performance on the Crossed Finger Localization Test (CFLT). Significant CC volume reductions in ROP subjects versus controls emerged after excluding substance misuse and non-right-handedness. CC reductions retained significance in the schizophrenia subgroup but not in affective psychoses subjects. There were significant positive correlations between CC volumes and CFLT scores in ROP subjects, specifically in subtasks involving interhemispheric communication. From these results, we can conclude that CC volume reductions are present in association with ROP. The relationship between such deficits and CFLT performance suggests that interhemispheric communication impairments are directly linked to CC abnormalities in ROP.

    M3 - Article

    VL - 184

    SP - 1

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    JO - Psychiatry research

    T2 - Psychiatry research

    JF - Psychiatry research

    SN - 0165-1781

    IS - 1

    ER -