Vitamin D3 supplementation in healthy adults: a comparison of capsule and oral spray solution as a method of delivery in a wintertime randomised, open-label crossover study

Joshua J Todd, Emeir M McSorley, L. Kirsty Pourshahidi, Sharon Madigan, Eamon Laird, Martin Healy, Pamela Magee

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1 Citation (Scopus)

Abstract

Vitamin D is typically supplied in capsule form, both in trials and clinical practice. Yet little is known regarding the efficacy of vitamin D administered via oral spray; a method that primarily bypasses the gastrointestinal absorption route. This study aimed to compare the efficacy of vitamin D3 liquid capsules and oral spray solution, at increasing wintertime total 25-hydroxyvitamin D[25(OH)D] concentrations. In this randomised, open-label crossover trial, healthy adults (n=22)received 3000IU (75μg) vitamin D3 daily for 4 weeks in either capsule or oral spray form.Following a 10-week washout phase, participants received the opposite treatment for a final 4 weeks. Anthropometrics and fasted blood samples were obtained pre and post-supplementation,with samples analysed for total 25(OH)D, creatinine, intact parathyroid hormone and adjusted calcium concentrations. At baseline, vitamin D sufficiency [total 25(OH)D >50nmol/L],insufficiency (31-49nmol/L) and clinical deficiency (
LanguageEnglish
Pages1402-1408
Number of pages4
JournalBRITISH JOURNAL OF NUTRITION
Volume116
Issue number8
Early online date11 Oct 2016
DOIs
Publication statusE-pub ahead of print - 11 Oct 2016

Fingerprint

Oral Sprays
Cholecalciferol
Vitamin D
Cross-Over Studies
Capsules
Parathyroid Hormone
Creatinine
Clinical Trials
Calcium

Keywords

  • oral spray
  • capsules
  • vitamin D supplementation
  • crossover
  • comparative effectiveness

Cite this

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title = "Vitamin D3 supplementation in healthy adults: a comparison of capsule and oral spray solution as a method of delivery in a wintertime randomised, open-label crossover study",
abstract = "Vitamin D is typically supplied in capsule form, both in trials and clinical practice. Yet little is known regarding the efficacy of vitamin D administered via oral spray; a method that primarily bypasses the gastrointestinal absorption route. This study aimed to compare the efficacy of vitamin D3 liquid capsules and oral spray solution, at increasing wintertime total 25-hydroxyvitamin D[25(OH)D] concentrations. In this randomised, open-label crossover trial, healthy adults (n=22)received 3000IU (75μg) vitamin D3 daily for 4 weeks in either capsule or oral spray form.Following a 10-week washout phase, participants received the opposite treatment for a final 4 weeks. Anthropometrics and fasted blood samples were obtained pre and post-supplementation,with samples analysed for total 25(OH)D, creatinine, intact parathyroid hormone and adjusted calcium concentrations. At baseline, vitamin D sufficiency [total 25(OH)D >50nmol/L],insufficiency (31-49nmol/L) and clinical deficiency (",
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author = "Todd, {Joshua J} and McSorley, {Emeir M} and Pourshahidi, {L. Kirsty} and Sharon Madigan and Eamon Laird and Martin Healy and Pamela Magee",
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AU - McSorley, Emeir M

AU - Pourshahidi, L. Kirsty

AU - Madigan, Sharon

AU - Laird, Eamon

AU - Healy, Martin

AU - Magee, Pamela

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AB - Vitamin D is typically supplied in capsule form, both in trials and clinical practice. Yet little is known regarding the efficacy of vitamin D administered via oral spray; a method that primarily bypasses the gastrointestinal absorption route. This study aimed to compare the efficacy of vitamin D3 liquid capsules and oral spray solution, at increasing wintertime total 25-hydroxyvitamin D[25(OH)D] concentrations. In this randomised, open-label crossover trial, healthy adults (n=22)received 3000IU (75μg) vitamin D3 daily for 4 weeks in either capsule or oral spray form.Following a 10-week washout phase, participants received the opposite treatment for a final 4 weeks. Anthropometrics and fasted blood samples were obtained pre and post-supplementation,with samples analysed for total 25(OH)D, creatinine, intact parathyroid hormone and adjusted calcium concentrations. At baseline, vitamin D sufficiency [total 25(OH)D >50nmol/L],insufficiency (31-49nmol/L) and clinical deficiency (

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