Vitamin D, Muscle Function, and Cardiorespiratory Fitness in Adolescents From the Young Hearts Study.

E L Carson, Kirsty Pourshahidi, T R Hill, K D Cashman, JJ Strain, C A Boreham, Maria S. Mulhern

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

CONTEXTVitamin D insufficiency is common among the adolescent population and may have implications for health outcomes in later life. Few studies have investigated the role of vitamin D status in muscle function and cardiorespiratory fitness (CRF) during adolescence.OBJECTIVEThe aim of this study was to investigate the association between vitamin D status and fat-free mass (FFM), muscle strength, muscle power, and CRF in a representative sample of adolescents from Northern Ireland.DESIGN, SETTING, AND PARTICIPANTSThis was a cross-sectional study involving 1015 adolescents (age 12 and 15 y), who had 25-hydroxyvitamin D [25(OH)D] data available as part of the Young Hearts Study 2000.MAIN OUTCOME MEASURESThe main outcome measures of this study were FFM (kg) and FFM corrected for height [fat-free mass index; FFM (kg)/height (m(2))], muscle strength (kg), peak muscle power (kW) and VO2 max (CRF; mL/kg/min).RESULTSMultinomial regression analyses, controlling for environmental and lifestyle factors, demonstrated that boys age 15 years in the highest tertile of standardized serum 25(OH)D concentration (> 51 nmol/L) had significantly higher muscle strength (β = 3.90; P ≤ .001) compared with those in the lowest tertile (<32 nmol/L). These results were not evident in any other age-sex group and vitamin D status was not significantly associated with muscle power or CRF in any of the four age-sex groups.CONCLUSIONThese results support a role for vitamin D in muscle function in adolescent males and suggest the need for more research in this vulnerable age group.
LanguageEnglish
Pages4621-4628
Number of pages7
JournalThe Journal of clinical endocrinology and metabolism
Volume100
Issue number12
DOIs
Publication statusPublished - Dec 2015

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Vitamin D
Fats
Muscle Strength
Muscles
Age Groups
Outcome Assessment (Health Care)
Northern Ireland
Life Style
Cross-Sectional Studies
Regression Analysis
Cardiorespiratory Fitness
Health
Serum
Research
Population
Power (Psychology)

Keywords

  • Vitamin D
  • muscle function
  • cardiorespiratory fitness
  • Adolescents

Cite this

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title = "Vitamin D, Muscle Function, and Cardiorespiratory Fitness in Adolescents From the Young Hearts Study.",
abstract = "CONTEXTVitamin D insufficiency is common among the adolescent population and may have implications for health outcomes in later life. Few studies have investigated the role of vitamin D status in muscle function and cardiorespiratory fitness (CRF) during adolescence.OBJECTIVEThe aim of this study was to investigate the association between vitamin D status and fat-free mass (FFM), muscle strength, muscle power, and CRF in a representative sample of adolescents from Northern Ireland.DESIGN, SETTING, AND PARTICIPANTSThis was a cross-sectional study involving 1015 adolescents (age 12 and 15 y), who had 25-hydroxyvitamin D [25(OH)D] data available as part of the Young Hearts Study 2000.MAIN OUTCOME MEASURESThe main outcome measures of this study were FFM (kg) and FFM corrected for height [fat-free mass index; FFM (kg)/height (m(2))], muscle strength (kg), peak muscle power (kW) and VO2 max (CRF; mL/kg/min).RESULTSMultinomial regression analyses, controlling for environmental and lifestyle factors, demonstrated that boys age 15 years in the highest tertile of standardized serum 25(OH)D concentration (> 51 nmol/L) had significantly higher muscle strength (β = 3.90; P ≤ .001) compared with those in the lowest tertile (<32 nmol/L). These results were not evident in any other age-sex group and vitamin D status was not significantly associated with muscle power or CRF in any of the four age-sex groups.CONCLUSIONThese results support a role for vitamin D in muscle function in adolescent males and suggest the need for more research in this vulnerable age group.",
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Vitamin D, Muscle Function, and Cardiorespiratory Fitness in Adolescents From the Young Hearts Study. / Carson, E L; Pourshahidi, Kirsty; Hill, T R; Cashman, K D; Strain, JJ; Boreham, C A; Mulhern, Maria S.

In: The Journal of clinical endocrinology and metabolism, Vol. 100, No. 12, 12.2015, p. 4621-4628.

Research output: Contribution to journalArticle

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T1 - Vitamin D, Muscle Function, and Cardiorespiratory Fitness in Adolescents From the Young Hearts Study.

AU - Carson, E L

AU - Pourshahidi, Kirsty

AU - Hill, T R

AU - Cashman, K D

AU - Strain, JJ

AU - Boreham, C A

AU - Mulhern, Maria S.

PY - 2015/12

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N2 - CONTEXTVitamin D insufficiency is common among the adolescent population and may have implications for health outcomes in later life. Few studies have investigated the role of vitamin D status in muscle function and cardiorespiratory fitness (CRF) during adolescence.OBJECTIVEThe aim of this study was to investigate the association between vitamin D status and fat-free mass (FFM), muscle strength, muscle power, and CRF in a representative sample of adolescents from Northern Ireland.DESIGN, SETTING, AND PARTICIPANTSThis was a cross-sectional study involving 1015 adolescents (age 12 and 15 y), who had 25-hydroxyvitamin D [25(OH)D] data available as part of the Young Hearts Study 2000.MAIN OUTCOME MEASURESThe main outcome measures of this study were FFM (kg) and FFM corrected for height [fat-free mass index; FFM (kg)/height (m(2))], muscle strength (kg), peak muscle power (kW) and VO2 max (CRF; mL/kg/min).RESULTSMultinomial regression analyses, controlling for environmental and lifestyle factors, demonstrated that boys age 15 years in the highest tertile of standardized serum 25(OH)D concentration (> 51 nmol/L) had significantly higher muscle strength (β = 3.90; P ≤ .001) compared with those in the lowest tertile (<32 nmol/L). These results were not evident in any other age-sex group and vitamin D status was not significantly associated with muscle power or CRF in any of the four age-sex groups.CONCLUSIONThese results support a role for vitamin D in muscle function in adolescent males and suggest the need for more research in this vulnerable age group.

AB - CONTEXTVitamin D insufficiency is common among the adolescent population and may have implications for health outcomes in later life. Few studies have investigated the role of vitamin D status in muscle function and cardiorespiratory fitness (CRF) during adolescence.OBJECTIVEThe aim of this study was to investigate the association between vitamin D status and fat-free mass (FFM), muscle strength, muscle power, and CRF in a representative sample of adolescents from Northern Ireland.DESIGN, SETTING, AND PARTICIPANTSThis was a cross-sectional study involving 1015 adolescents (age 12 and 15 y), who had 25-hydroxyvitamin D [25(OH)D] data available as part of the Young Hearts Study 2000.MAIN OUTCOME MEASURESThe main outcome measures of this study were FFM (kg) and FFM corrected for height [fat-free mass index; FFM (kg)/height (m(2))], muscle strength (kg), peak muscle power (kW) and VO2 max (CRF; mL/kg/min).RESULTSMultinomial regression analyses, controlling for environmental and lifestyle factors, demonstrated that boys age 15 years in the highest tertile of standardized serum 25(OH)D concentration (> 51 nmol/L) had significantly higher muscle strength (β = 3.90; P ≤ .001) compared with those in the lowest tertile (<32 nmol/L). These results were not evident in any other age-sex group and vitamin D status was not significantly associated with muscle power or CRF in any of the four age-sex groups.CONCLUSIONThese results support a role for vitamin D in muscle function in adolescent males and suggest the need for more research in this vulnerable age group.

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KW - muscle function

KW - cardiorespiratory fitness

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SP - 4621

EP - 4628

JO - Journal of Clinical Endocrinology and Metabolism

T2 - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

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