Objective: To investigate vitamin B6 and riboflavin status, their metabolic interaction and relationship with methylenetetrahydrofolate reductase (MTHFR) genotype in adulthood.
Design: Data from 5612 adults aged 18-102y were drawn from the Irish National Adult Nutrition Survey (NANS; population-based sample) and the Trinity-Ulster-Department of Agriculture (TUDA) and Genovit cohorts (volunteer samples). Plasma PLP and erythrocyte glutathione reductase activation coefficient (EGRac), as a functional indicator of riboflavin, were determined.
Results: Older (≥65y) compared to younger (Conclusions: These results are consistent with the known metabolic dependency of PLP on FMN and suggest that riboflavin may be the limiting nutrient for maintaining vitamin B6 status, particularly in individuals with the MTHFR 677TT genotype. Randomized trials are necessary to investigate the PLP response to riboflavin intervention within the dietary range.
|Number of pages||38|
|Journal||The American Journal of Clinical Nutrition|
|Publication status||Accepted/In press - 19 Aug 2022|
- Vitamin B6
- pyridoxal 5’-phosphate
- erythrocyte glutathione reductase activation coefficient
- B-vitamin biomarkers
- dietary intakes
- Trinity-Ulster-Department of Agriculture (TUDA)