Abstract
Structural biomarkers determined by X-ray scattering of the tissues can complement conventional diagnostics and provide a pathway for early detection of diseases. In the present study, mouse models were utilized to observe the progression of prostate cancer. We induced cancer in the left lobe of the mouse prostate, whilst the right lobe was left uninoculated. The mice were sacrificed at increasing systematic time points, and lobe samples were subsequently analyzed using X-ray scattering. Control samples were also collected from healthy mice sacrificed at the same time points. This investigation revealed that the ratio between the X-ray scattering peaks associated with the lipids and water can serve as a structural biomarker of cancer, and this biomarker develops as the tumor advances. The obtained cancer trajectory can serve as a baseline for the determination of the disease stage, and the biomarker movement along the trajectory can be evidence of the healing or disease progression.
| Original language | English |
|---|---|
| Article number | 904 |
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | Life |
| Volume | 15 |
| Issue number | 6 |
| Early online date | 3 Jun 2025 |
| DOIs | |
| Publication status | Published (in print/issue) - 30 Jun 2025 |
Bibliographical note
Publisher Copyright:© 2025 by the authors.
Data Access Statement
The files with the XRD patterns are available at https://doi.org/10.5281/zenodo.14751060, published 27 January 2025. The codes for the image processing are available upon request.
Keywords
- vitacrystallography
- X-ray scattering
- structural biomarkers
- mouse model
- prostate cancer
- cancer trajectory
- Structural Biomarkers
- Cancer Trajectory
- Vitacrystallography
- Mouse Model
