Viral nanoparticles where we are heading

Alaa A.A. Aljabali, Mohammad A. Obeid, Murtaza M. Tambuwala, Kamal Dua, Kaushik Pal

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Nanotechnology is a multidisciplinary field that sits at the interface of chemistry, biology, materials science, and medicine. The utilization of materials derived from natural sources has allowed the harnessing of highly organized macromolecules for various applications in nanomedicine. Viral nanoparticles are both biocompatible and biodegradable and can be engineered chemically and genetically to impart new functionalities. Viral particles, for example, plant viruses with well-characterized properties. They are deemed as a natural, very robust, nanoscale assemblies. The virus particles can be chemically modified both externally and internally with high precision with various functionalities to act as a platform for the next-generation therapeutics, bio-imaging, drug targeting, and as drug carriers. Besides, the virus capsid can be genetically modified to introduce unnatural amino acids, which aid in monitoring the virus assembly and allowing the design of Nanocapsules for the loading with the desired anticancer drugs. Preserving the virus capsid allows the particles to be modified with targeting moieties to guide the nanoparticles to the diseased cells for selective imaging and treatment. Viruses are novel new type of nanomaterials with exciting potential in molecular imaging and drug delivery. Viral nanoparticles are deemed as a biodegradable and biocompatible and very suitable for in vivo and in vitro drug delivery and for molecular imaging tools.

Original languageEnglish
Title of host publicationMultidisciplinary Science and Advanced Technologies
EditorsKaushik Pal, Fernando Gomes, Thinakaran Narayanan
PublisherNova Science Publishers, Inc.
Pages85-91
Number of pages7
ISBN (Electronic)9781536191981
Publication statusPublished - 27 Jan 2021

Keywords

  • Drug delivery
  • Molecular imaging
  • Nanotechnology
  • Viral nanoparticles
  • Viruses

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