(Val(8) )GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice.

R Lennox; DW Porter; Peter Flatt; Victor Gault

doi:10.1002/cmdc.201200409

(Val(8) )GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice.

R Lennox
, DW Porter
, Peter Flatt
, Victor Gault

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

This study examined the biological properties of a novel GLP-1 peptide, (Val(8) )GLP-1-Glu-PAL, engineered with an Ala(8) →Val(8) substitution and additional incorporation of a C(16) fatty acid moiety at Lys(26) via a glutamic acid linker. GLP-1 underwent 75 % degradation by DPP-IV over 8 h, whereas (Val(8) )GLP-1 and (Val(8) )GLP-1-Glu-PAL remained intact. All GLP-1 peptides significantly stimulated insulin secretion at 5.6 mM (1.3- to 4.9-fold, p

Original language	English
Pages (from-to)	595-602
Journal	ChemMedChem
Volume	8
Issue number	4
DOIs	https://doi.org/10.1002/cmdc.201200409
Publication status	Published (in print/issue) - 1 Mar 2013

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10.1002/cmdc.201200409

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abstract = "This study examined the biological properties of a novel GLP-1 peptide, (Val(8) )GLP-1-Glu-PAL, engineered with an Ala(8) →Val(8) substitution and additional incorporation of a C(16) fatty acid moiety at Lys(26) via a glutamic acid linker. GLP-1 underwent 75 \% degradation by DPP-IV over 8 h, whereas (Val(8) )GLP-1 and (Val(8) )GLP-1-Glu-PAL remained intact. All GLP-1 peptides significantly stimulated insulin secretion at 5.6 mM (1.3- to 4.9-fold, p",

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AU - Porter, DW

AU - Flatt, Peter

AU - Gault, Victor

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AB - This study examined the biological properties of a novel GLP-1 peptide, (Val(8) )GLP-1-Glu-PAL, engineered with an Ala(8) →Val(8) substitution and additional incorporation of a C(16) fatty acid moiety at Lys(26) via a glutamic acid linker. GLP-1 underwent 75 % degradation by DPP-IV over 8 h, whereas (Val(8) )GLP-1 and (Val(8) )GLP-1-Glu-PAL remained intact. All GLP-1 peptides significantly stimulated insulin secretion at 5.6 mM (1.3- to 4.9-fold, p

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(Val(8) )GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice.

Abstract

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