(Val(8) )GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice.

R Lennox, DW Porter, Peter Flatt, Victor Gault

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

This study examined the biological properties of a novel GLP-1 peptide, (Val(8) )GLP-1-Glu-PAL, engineered with an Ala(8) →Val(8) substitution and additional incorporation of a C(16) fatty acid moiety at Lys(26) via a glutamic acid linker. GLP-1 underwent 75 % degradation by DPP-IV over 8 h, whereas (Val(8) )GLP-1 and (Val(8) )GLP-1-Glu-PAL remained intact. All GLP-1 peptides significantly stimulated insulin secretion at 5.6 mM (1.3- to 4.9-fold, p
Original languageEnglish
Pages (from-to)595-602
JournalChemMedChem
Volume8
Issue number4
DOIs
Publication statusPublished - 1 Mar 2013

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