(Val(8) )GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice.

R Lennox, DW Porter, Peter Flatt, Victor Gault

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This study examined the biological properties of a novel GLP-1 peptide, (Val(8) )GLP-1-Glu-PAL, engineered with an Ala(8) →Val(8) substitution and additional incorporation of a C(16) fatty acid moiety at Lys(26) via a glutamic acid linker. GLP-1 underwent 75 % degradation by DPP-IV over 8 h, whereas (Val(8) )GLP-1 and (Val(8) )GLP-1-Glu-PAL remained intact. All GLP-1 peptides significantly stimulated insulin secretion at 5.6 mM (1.3- to 4.9-fold, p
LanguageEnglish
Pages595-602
JournalChemMedChem
Volume8
Issue number4
DOIs
Publication statusPublished - 1 Mar 2013

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Glucagon-Like Peptide 1
Neurogenesis
Homeostasis
Fats
Glucose
Peptides
Glutamic Acid
Fatty Acids
Insulin

Cite this

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(Val(8) )GLP-1-Glu-PAL: a GLP-1 Agonist That Improves Hippocampal Neurogenesis, Glucose Homeostasis, and β-Cell Function in High-Fat-Fed Mice. / Lennox, R; Porter, DW; Flatt, Peter; Gault, Victor.

In: ChemMedChem, Vol. 8, No. 4, 01.03.2013, p. 595-602.

Research output: Contribution to journalArticle

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