Use of logic theory in understanding regulatory pathway signaling in response to infection

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Biological pathways link the molecular and cellular levels of biological activityand perform complex information processing seamlessly. Systems biology aims to combine an understanding of the cause–effect relationships of each individual interaction to build an understanding of the function of whole pathways. Therapies that target the ‘host’ biological processes in infectious diseases are often limited to the use of vaccines and biologics rather than small molecules. The development of host drug-targets for small molecules is constrained by a limited knowledge of the underlying role of each target, particularly its potential to cause harmful side effects after targeting. By considering the combinatorial complexity of pathways from the outset, we can develop modeling tools that are better suited to analyzing large pathways, enabling us to identify new causal relationships. This could lead to new drug target strategies that beneficially disrupt host–pathogen interactions, minimizing the number of side effects. We introduce logic theory as part of a pathway modeling approach that can provide a new framework for understanding pathways and refine ‘host-based’ drug target identification strategies.
    LanguageEnglish
    Pages163-176
    JournalFuture Microbiology
    Volume5
    Issue number2
    DOIs
    Publication statusPublished - Feb 2010

    Fingerprint

    Infection
    Pharmaceutical Preparations
    Biological Phenomena
    Systems Biology
    Biological Products
    Automatic Data Processing
    Communicable Diseases
    Vaccines
    Therapeutics

    Keywords

    • Host-pathogen
    • Immune response
    • logic modelling
    • pathway
    • systems biology

    Cite this

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    title = "Use of logic theory in understanding regulatory pathway signaling in response to infection",
    abstract = "Biological pathways link the molecular and cellular levels of biological activityand perform complex information processing seamlessly. Systems biology aims to combine an understanding of the cause–effect relationships of each individual interaction to build an understanding of the function of whole pathways. Therapies that target the ‘host’ biological processes in infectious diseases are often limited to the use of vaccines and biologics rather than small molecules. The development of host drug-targets for small molecules is constrained by a limited knowledge of the underlying role of each target, particularly its potential to cause harmful side effects after targeting. By considering the combinatorial complexity of pathways from the outset, we can develop modeling tools that are better suited to analyzing large pathways, enabling us to identify new causal relationships. This could lead to new drug target strategies that beneficially disrupt host–pathogen interactions, minimizing the number of side effects. We introduce logic theory as part of a pathway modeling approach that can provide a new framework for understanding pathways and refine ‘host-based’ drug target identification strategies.",
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    Use of logic theory in understanding regulatory pathway signaling in response to infection. / Watterson, Steven.

    In: Future Microbiology, Vol. 5, No. 2, 02.2010, p. 163-176.

    Research output: Contribution to journalArticle

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