TY - JOUR
T1 - Urotensin II, from fish to human
AU - Vaudry, Hubert
AU - Do Rego, Jean Claude
AU - Le Mevel, Jean Claude
AU - Chatenet, David
AU - Tostivint, Hervé
AU - Fournier, Alain
AU - Tonon, Marie Christine
AU - Pelletier, Georges
AU - Michael Conlon, J.
AU - Leprince, Jérôme
PY - 2010/7
Y1 - 2010/7
N2 - The cyclic peptide urotensin II (UII) was originally isolated from the urophysis of teleost fish on the basis of its ability to contract intestinal smooth muscle. The UII peptide has subsequently been isolated from frog brain and, later on, the pre-proUII cDNA has been characterized in mammals, including humans. A UII paralog called urotensin II-related peptide (URP) has been identified in the rat brain. The UII and URP genes originate from the same ancestral gene as the somatostatin and cortistatin genes. In the central nervous system (CNS) of tetrapods, UII is expressed primarily in motoneurons of the brainstem and spinal cord. The biological actions of UII and URP are mediated through a G protein-coupled receptor, termed UT, that exhibits high sequence similarity with the somatostatin receptors. The UT gene is widely expressed in the CNS and in peripheral organs. Consistent with the broad distribution of UT, UII and URP exert a large array of behavioral effects and regulate endocrine, cardiovascular, renal, and immune functions.
AB - The cyclic peptide urotensin II (UII) was originally isolated from the urophysis of teleost fish on the basis of its ability to contract intestinal smooth muscle. The UII peptide has subsequently been isolated from frog brain and, later on, the pre-proUII cDNA has been characterized in mammals, including humans. A UII paralog called urotensin II-related peptide (URP) has been identified in the rat brain. The UII and URP genes originate from the same ancestral gene as the somatostatin and cortistatin genes. In the central nervous system (CNS) of tetrapods, UII is expressed primarily in motoneurons of the brainstem and spinal cord. The biological actions of UII and URP are mediated through a G protein-coupled receptor, termed UT, that exhibits high sequence similarity with the somatostatin receptors. The UT gene is widely expressed in the CNS and in peripheral organs. Consistent with the broad distribution of UT, UII and URP exert a large array of behavioral effects and regulate endocrine, cardiovascular, renal, and immune functions.
KW - behavioral effects
KW - cardiovascular system
KW - evolution
KW - urotensin II
KW - URP
KW - UT
UR - http://www.scopus.com/inward/record.url?scp=77954581188&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2010.05514.x
DO - 10.1111/j.1749-6632.2010.05514.x
M3 - Article
AN - SCOPUS:77954581188
SN - 0077-8923
VL - 1200
SP - 53
EP - 66
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -