Slip length describes the classical no-slip boundary condition violation of Newtonian fluid mechanics, where fluids glide on the solid surfaces. Here, we propose a new analytical model validated by experiments for characterization of the liquid slip using vibrating solid surfaces. Essentially, we use a microfluidic system integrated with quartz crystal microbalance (QCM) to investigate the relationship between the slip and the mechanical response of a vibrating solid for a moving fluid. We discover a liquid slip that emerges especially at high flow rates, which is independent of the surface wetting condition, having significant contributions to the changes in resonant frequency of the vibrating solid and energy dissipation on its surface. Overall, our work will lead to consideration of ‘missing slip’ in the vibrating solid-liquid systems such as the QCM-based biosensing where traditionally frequency changes are interpreted exclusively with mass change on the sensor surface, irrespective of the flow conditions.