TY - JOUR
T1 - Ultra-sensitive detection of L-tyrosine using molecularly imprinted electrochemical sensor towards diabetic foot ulcer detection
AU - Davis, J
AU - Roy, Souradeep
AU - Nagabooshanam, Shalini
AU - Wadhwa, Shikha
AU - Chauhan, Nidhi
AU - Khan, Saif
AU - Mathur, Ashish
PY - 2020/8/31
Y1 - 2020/8/31
N2 - It has been found that the concentration of L-tyrosine is greatly elevated within infected ulcers and thus there is a pressing need for sensors that can aid the point of care monitoring of this potential biomarker. In this work, a templated over-oxidised polypyrrole film on indium tin oxide is exploited as a sensitive sensing system, for the detection of tyrosine. The sensor has been characterised using a variety of surface techniques (contact angle, FTIR, SEM) and the electrochemical properties explored using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The sensor was found to exhibit a substantial linear range (100 fM–1 mM) with limits of detection of 1.73 pM (CV) and 6.63 pM (EIS). The sensor demonstrated rapid response characteristics (less than 1 min) and high stability (up to 3 months).
AB - It has been found that the concentration of L-tyrosine is greatly elevated within infected ulcers and thus there is a pressing need for sensors that can aid the point of care monitoring of this potential biomarker. In this work, a templated over-oxidised polypyrrole film on indium tin oxide is exploited as a sensitive sensing system, for the detection of tyrosine. The sensor has been characterised using a variety of surface techniques (contact angle, FTIR, SEM) and the electrochemical properties explored using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The sensor was found to exhibit a substantial linear range (100 fM–1 mM) with limits of detection of 1.73 pM (CV) and 6.63 pM (EIS). The sensor demonstrated rapid response characteristics (less than 1 min) and high stability (up to 3 months).
KW - Infection
KW - Molecularly imprinted polymer
KW - Point of care
KW - Sensor
KW - Tyrosine
UR - http://www.scopus.com/inward/record.url?scp=85087504363&partnerID=8YFLogxK
U2 - 10.1016/j.elecom.2020.106782
DO - 10.1016/j.elecom.2020.106782
M3 - Article
SN - 1388-2481
VL - 117
JO - Electrochemistry Communications
JF - Electrochemistry Communications
M1 - 106782
ER -