Ultra-sensitive detection of L-tyrosine using molecularly imprinted electrochemical sensor towards diabetic foot ulcer detection

J Davis, Souradeep Roy, Shalini Nagabooshanam, Shikha Wadhwa, Nidhi Chauhan, Saif Khan, Ashish Mathur

Research output: Contribution to journalArticle

Abstract

It has been found that the concentration of L-tyrosine is greatly elevated within infected ulcers and thus there is a pressing need for sensors that can aid the point of care monitoring of this potential biomarker. In this work, a templated over-oxidised polypyrrole film on indium tin oxide is exploited as a sensitive sensing system, for the detection of tyrosine. The sensor has been characterised using a variety of surface techniques (contact angle, FTIR, SEM) and the electrochemical properties explored using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The sensor was found to exhibit a substantial linear range (100 fM–1 mM) with limits of detection of 1.73 pM (CV) and 6.63 pM (EIS). The sensor demonstrated rapid response characteristics (less than 1 min) and high stability (up to 3 months).

Original languageEnglish
Article number106782
Number of pages11
JournalElectrochemistry Communications
Volume117
Early online date27 Jun 2020
DOIs
Publication statusPublished - 31 Aug 2020

Keywords

  • Infection
  • Molecularly imprinted polymer
  • Point of care
  • Sensor
  • Tyrosine

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