Two novel glucagon receptor antagonists prove effective therapeutic agents in high-fat-fed and obese diabetic mice

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Abstract

Aims: To examine the effect of two novel, enzymatically stable, glucagon receptor peptide antagonists, on metabolic control in two mouse models ofobesity/diabetes.Method: The effects of twice daily i.p. administration of desHis1Pro4Glu9-glucagon or desHis1Pro4Glu9Lys12FA-glucagon for 10 days on metaboliccontrol in high-fat-fed (HFF; 45% fat) and obese diabetic (ob/ob) mice were compared with saline-treated controls.Results: Neither analogue altered body weight or food intake in either model over 10 days; however, treatment with each peptide restored non-fastingblood glucose towards normal control values in HFF mice. Basal glucose was also reduced (p
LanguageEnglish
Pages1214-1222
JournalDiabetes Obesity and Metabolism
Volume16
Issue number12
DOIs
Publication statusPublished - 1 Dec 2014

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Glucagon Receptors
Obese Mice
Fats
Glucagon
Glucose
Peptides
Reference Values
Therapeutics
Eating
Body Weight

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abstract = "Aims: To examine the effect of two novel, enzymatically stable, glucagon receptor peptide antagonists, on metabolic control in two mouse models ofobesity/diabetes.Method: The effects of twice daily i.p. administration of desHis1Pro4Glu9-glucagon or desHis1Pro4Glu9Lys12FA-glucagon for 10 days on metaboliccontrol in high-fat-fed (HFF; 45{\%} fat) and obese diabetic (ob/ob) mice were compared with saline-treated controls.Results: Neither analogue altered body weight or food intake in either model over 10 days; however, treatment with each peptide restored non-fastingblood glucose towards normal control values in HFF mice. Basal glucose was also reduced (p",
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Two novel glucagon receptor antagonists prove effective therapeutic agents in high-fat-fed and obese diabetic mice. / O'Harte, Finbarr; Franklin, ZJ; Irwin, Nigel.

In: Diabetes Obesity and Metabolism, Vol. 16, No. 12, 01.12.2014, p. 1214-1222.

Research output: Contribution to journalArticle

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