Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles

Christopher McLaughlin, Shaun Sharkey, Padraigin Harnedy-Rothwell, Parthsarathy V, Philip J Allsopp, Emeir M. McSorley, Richard J FitzGerald, Finbarr O'Harte

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Abstract

This study investigated the antihyperglycaemic effectiveness of an oral Palmaria palmata protein hydrolysate (PPPH), versus metformin, upon metabolic control in streptozotocin (STZ)-induced diabetic mice. Mice were administered PPPH (50 mg/kg bodyweight) or metformin (200 mg/kg bodyweight) by oral gavage twice-daily for 18 days. Blood glucose and plasma insulin were measured every third day. PPPH caused a significant reduction in blood glucose (p < 0.001) and a significant increase in plasma insulin (p < 0.001) versus STZ-treated saline controls. PPPH treatment reduced energy intake (p < 0.05), bodyweight (p < 0.01) and total plasma glucagon-like peptide-1 (p < 0.01) after 18 days. Terminal oral glucose tolerance (Day 18, p < 0.05), fasting blood glucose (p < 0.001), HbA1C (p < 0.01), plasma cholesterol (p < 0.01) and plasma triglycerides (p < 0.05) were significantly improved versus STZ-treated saline controls. All groups showed significant increases in pancreatic islet area, β-cell area, and β:α cell ratio. PPPH demonstrated potent antidiabetic potential in vivo through reduced food intake and improved beta-cell function.

Original languageEnglish
Article number104101
JournalJournal of Functional Foods
Volume73
Early online date10 Jul 2020
DOIs
Publication statusE-pub ahead of print - 10 Jul 2020

Keywords

  • Blood glucose
  • GLP-1
  • Insulin secretion
  • Palmaria palmata
  • Protein hydrolysate
  • Streptozotocin induced diabetes

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