Tricyclic antidepressant overdose in a toddler treated with intravenous lipid emulsion.

David Hendron, Gareth Menagh, Euan Sandilands, Damian Scullion

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


We report a case that involves the use of intravenous lipid emulsion as an antidote for a drug overdose involving a 20-month-old girl who had ingested a potentially lethal amount of the tricyclic antidepressant (TCA) dothiepin. The patient's condition continued to deteriorate despite implementation of standard pediatric treatment recommendations for TCA toxicity. Administration of intravenous lipid emulsion in addition to standard therapy (including sodium bicarbonate) and direct-current cardioversion for ventricular arrhythmia led to a successful outcome. The case report is followed by a review of the current evidence underlying this novel therapy and the background on its use. TCA toxicity is addressed specifically.
Original languageEnglish
Pages (from-to)1628-32
Issue number6
Publication statusPublished (in print/issue) - 1 Dec 2011


  • tricyclic antidepressant overdose
  • dothiepin
  • intravenous lipid emulsion
  • Intralipid


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