Tri-Needle Coaxial Electrospray Engineering of Magnetic Polymer Yolk-Shell Particles Possessing Dual-Imaging Modality, Multiagent Compartments, and Trigger Release Potential

Chunchen Zhang, Zhi Cheng Yao, Qiuping Ding, James J. Choi, Zeeshan Ahmad, Ming Wei Chang, Jing Song Li

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Particulate platforms capable of delivering multiple actives as well as providing diagnostic features have gained considerable interest over the last few years. In this study, magnetic polymer yolk-shell particles (YSPs) were engineered using a tri-needle coaxial electrospraying technique enabling dual-mode (ultrasonic and magnetic resonance) imaging capability with specific multidrug compartments via an advanced single-step encapsulation process. YSPs comprised magnetic Fe3O4 nanoparticles (MNPs) embedded in the polymeric shell, an interfacing oil layer, and a polymeric core (i.e., composite shell-oil interface-polymeric core). The frequency of the ultrasound backscatter signal was modulated through YSP loading dosage, and both T1- and T2-weighted magnetic resonance imaging signal intensities were shown to decrease with increasing MNP content (YSP outer shell). Three fluorescent dyes (selected as model probes with varying hydrophobicities) were coencapsulated separately to confirm the YSP structure. Probe release profiles were tuned by varying power or frequency of an external auxiliary magnetic field (AMF, 0.7 mT (LAMF) or 1.4 mT (HAMF)). In addition, an "inversion" phenomenon for the AMF-enhanced drug release process was studied and is reported. A low YSP cytotoxicity (5 mg/mL) and biocompatibility (murine, L929) was confirmed. In summary, magnetic YSPs demonstrate timely potential as multifunctional theranostic agents for dual-imaging modality and magnetically controlled coactive delivery.

LanguageEnglish
Pages21485-21495
Number of pages11
JournalACS Applied Materials and Interfaces
Volume9
Issue number25
DOIs
Publication statusPublished - 7 Jun 2017

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Needles
Polymers
Magnetic resonance
Imaging techniques
Oils
Ultrasonics
Nanoparticles
Cytotoxicity
Hydrophobicity
Biocompatibility
Fluorescent Dyes
Encapsulation
Dyes
Magnetic fields
Composite materials
Pharmaceutical Preparations

Keywords

  • auxiliary magnetic field
  • controlled release
  • dual-imaging modality
  • electrospray
  • multidrug release
  • yolk-shell particles

Cite this

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title = "Tri-Needle Coaxial Electrospray Engineering of Magnetic Polymer Yolk-Shell Particles Possessing Dual-Imaging Modality, Multiagent Compartments, and Trigger Release Potential",
abstract = "Particulate platforms capable of delivering multiple actives as well as providing diagnostic features have gained considerable interest over the last few years. In this study, magnetic polymer yolk-shell particles (YSPs) were engineered using a tri-needle coaxial electrospraying technique enabling dual-mode (ultrasonic and magnetic resonance) imaging capability with specific multidrug compartments via an advanced single-step encapsulation process. YSPs comprised magnetic Fe3O4 nanoparticles (MNPs) embedded in the polymeric shell, an interfacing oil layer, and a polymeric core (i.e., composite shell-oil interface-polymeric core). The frequency of the ultrasound backscatter signal was modulated through YSP loading dosage, and both T1- and T2-weighted magnetic resonance imaging signal intensities were shown to decrease with increasing MNP content (YSP outer shell). Three fluorescent dyes (selected as model probes with varying hydrophobicities) were coencapsulated separately to confirm the YSP structure. Probe release profiles were tuned by varying power or frequency of an external auxiliary magnetic field (AMF, 0.7 mT (LAMF) or 1.4 mT (HAMF)). In addition, an {"}inversion{"} phenomenon for the AMF-enhanced drug release process was studied and is reported. A low YSP cytotoxicity (5 mg/mL) and biocompatibility (murine, L929) was confirmed. In summary, magnetic YSPs demonstrate timely potential as multifunctional theranostic agents for dual-imaging modality and magnetically controlled coactive delivery.",
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author = "Chunchen Zhang and Yao, {Zhi Cheng} and Qiuping Ding and Choi, {James J.} and Zeeshan Ahmad and Chang, {Ming Wei} and Li, {Jing Song}",
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Tri-Needle Coaxial Electrospray Engineering of Magnetic Polymer Yolk-Shell Particles Possessing Dual-Imaging Modality, Multiagent Compartments, and Trigger Release Potential. / Zhang, Chunchen; Yao, Zhi Cheng; Ding, Qiuping; Choi, James J.; Ahmad, Zeeshan; Chang, Ming Wei; Li, Jing Song.

In: ACS Applied Materials and Interfaces, Vol. 9, No. 25, 07.06.2017, p. 21485-21495.

Research output: Contribution to journalArticle

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AU - Zhang, Chunchen

AU - Yao, Zhi Cheng

AU - Ding, Qiuping

AU - Choi, James J.

AU - Ahmad, Zeeshan

AU - Chang, Ming Wei

AU - Li, Jing Song

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