Treatment of fibrotic interstitial lung disease: current approaches and future directions

Kerri A Johannson; Nazia Chaudhuri; Ayodeji Adegunsoye; Paul J Wolters

doi:10.1016/S0140-6736(21)01826-2

Treatment of fibrotic interstitial lung disease: current approaches and future directions

Kerri A Johannson, Nazia Chaudhuri, Ayodeji Adegunsoye, Paul J Wolters

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that are often progressive and associated with high morbidity and early mortality. Important advancements in the past 10 years have enabled a better understanding, characterisation, and treatment of these diseases. This Series paper summarises the current approach to treatment of fibrotic ILDs, both pharmacological and non-pharmacological, including recent discoveries and practice-changing clinical trials. We further outline controversies and challenges, with discussion of evolving concepts and future research directions.

Original language	English
Pages (from-to)	1450-1460
Number of pages	11
Journal	Lancet
Volume	398
Issue number	10309
Early online date	6 Sept 2021
DOIs	https://doi.org/10.1016/S0140-6736(21)01826-2
Publication status	Published (in print/issue) - 16 Oct 2021

Bibliographical note

Keywords

Humans
Lung Diseases, Interstitial/drug therapy
Pulmonary Fibrosis/drug therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0140-6736(21)01826-2

Cite this

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title = "Treatment of fibrotic interstitial lung disease: current approaches and future directions",

abstract = "Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that are often progressive and associated with high morbidity and early mortality. Important advancements in the past 10 years have enabled a better understanding, characterisation, and treatment of these diseases. This Series paper summarises the current approach to treatment of fibrotic ILDs, both pharmacological and non-pharmacological, including recent discoveries and practice-changing clinical trials. We further outline controversies and challenges, with discussion of evolving concepts and future research directions.",

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T2 - current approaches and future directions

AU - Johannson, Kerri A

AU - Chaudhuri, Nazia

AU - Adegunsoye, Ayodeji

AU - Wolters, Paul J

PY - 2021/10/16

Y1 - 2021/10/16

N2 - Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that are often progressive and associated with high morbidity and early mortality. Important advancements in the past 10 years have enabled a better understanding, characterisation, and treatment of these diseases. This Series paper summarises the current approach to treatment of fibrotic ILDs, both pharmacological and non-pharmacological, including recent discoveries and practice-changing clinical trials. We further outline controversies and challenges, with discussion of evolving concepts and future research directions.

AB - Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that are often progressive and associated with high morbidity and early mortality. Important advancements in the past 10 years have enabled a better understanding, characterisation, and treatment of these diseases. This Series paper summarises the current approach to treatment of fibrotic ILDs, both pharmacological and non-pharmacological, including recent discoveries and practice-changing clinical trials. We further outline controversies and challenges, with discussion of evolving concepts and future research directions.

KW - Humans

KW - Lung Diseases, Interstitial/drug therapy

KW - Pulmonary Fibrosis/drug therapy

U2 - 10.1016/S0140-6736(21)01826-2

DO - 10.1016/S0140-6736(21)01826-2

M3 - Review article

C2 - 34499866

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VL - 398

SP - 1450

EP - 1460

JO - Lancet

JF - Lancet

IS - 10309

ER -

Treatment of fibrotic interstitial lung disease: current approaches and future directions

Abstract

Bibliographical note

Keywords

UN SDGs

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Cite this