Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults

JV Woodside, R McMahon, AM Gallagher, GW Cran, CA Boreham, LJ Murray, JJ STRAIN, H McNulty, PJ Robson, KS Brown, AS Whitehead, M Savage, IS Young

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Aims: Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension. The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determinants of tHcy and PWV in healthy young adults. Methods and results: A total of 489 subjects aged 20-25 years participated. A fasting blood sample was taken and PWV measured using a non-invasive optical method. tHcy did not correlate with PWV, whether assessed at the aono-iliac segment (P = 0.18), the aorto-radial segment (P = 0.39) or the aorto-dorsalis-pedis segment (P = 0.22). When tHcy was classified into normal (< 15) and high (greater than or equal to 15 mumol/l) PWV did not differ between the two groups at any segment. PWV did not differ by MTHFR C677T or NOS3 G894T genotype, even when smoking and folate sub-groups were considered. Considering aortic PWV as a dependent variable, stepwise regression analysis showed that the only parameter entering the model for all segments was systolic blood pressure (aorto-iliac, P < 0.001; aorto-radial, P = 0.01; aorto-dorsalis-pedis, P = 0.001). Age, sex, COL1A1 genotype and triglycerides entered the model significantly for two of three segments. Conclusion: This study shows that arterial PWV is not associated with tHcy in a healthy young population. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
LanguageEnglish
Pages337-344
JournalAtherosclerosis
Volume177
Issue number2
DOIs
Publication statusPublished - Dec 2004

Fingerprint

Pulse Wave Analysis
Homocysteine
Young Adult
Genotype
Blood Pressure
Hyperhomocysteinemia
Folic Acid
Chronic Kidney Failure
Molecular Biology
Fasting
Triglycerides
Smoking
Regression Analysis
Hypertension

Cite this

Woodside, JV ; McMahon, R ; Gallagher, AM ; Cran, GW ; Boreham, CA ; Murray, LJ ; STRAIN, JJ ; McNulty, H ; Robson, PJ ; Brown, KS ; Whitehead, AS ; Savage, M ; Young, IS. / Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults. In: Atherosclerosis. 2004 ; Vol. 177, No. 2. pp. 337-344.
@article{f1776a61e9e44c5093e318911bf5f72d,
title = "Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults",
abstract = "Aims: Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension. The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determinants of tHcy and PWV in healthy young adults. Methods and results: A total of 489 subjects aged 20-25 years participated. A fasting blood sample was taken and PWV measured using a non-invasive optical method. tHcy did not correlate with PWV, whether assessed at the aono-iliac segment (P = 0.18), the aorto-radial segment (P = 0.39) or the aorto-dorsalis-pedis segment (P = 0.22). When tHcy was classified into normal (< 15) and high (greater than or equal to 15 mumol/l) PWV did not differ between the two groups at any segment. PWV did not differ by MTHFR C677T or NOS3 G894T genotype, even when smoking and folate sub-groups were considered. Considering aortic PWV as a dependent variable, stepwise regression analysis showed that the only parameter entering the model for all segments was systolic blood pressure (aorto-iliac, P < 0.001; aorto-radial, P = 0.01; aorto-dorsalis-pedis, P = 0.001). Age, sex, COL1A1 genotype and triglycerides entered the model significantly for two of three segments. Conclusion: This study shows that arterial PWV is not associated with tHcy in a healthy young population. (C) 2004 Elsevier Ireland Ltd. All rights reserved.",
author = "JV Woodside and R McMahon and AM Gallagher and GW Cran and CA Boreham and LJ Murray and JJ STRAIN and H McNulty and PJ Robson and KS Brown and AS Whitehead and M Savage and IS Young",
year = "2004",
month = "12",
doi = "10.1016/j.atherosclerosis.2004.07.001",
language = "English",
volume = "177",
pages = "337--344",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier",
number = "2",

}

Woodside, JV, McMahon, R, Gallagher, AM, Cran, GW, Boreham, CA, Murray, LJ, STRAIN, JJ, McNulty, H, Robson, PJ, Brown, KS, Whitehead, AS, Savage, M & Young, IS 2004, 'Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults', Atherosclerosis, vol. 177, no. 2, pp. 337-344. https://doi.org/10.1016/j.atherosclerosis.2004.07.001

Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults. / Woodside, JV; McMahon, R; Gallagher, AM; Cran, GW; Boreham, CA; Murray, LJ; STRAIN, JJ; McNulty, H; Robson, PJ; Brown, KS; Whitehead, AS; Savage, M; Young, IS.

In: Atherosclerosis, Vol. 177, No. 2, 12.2004, p. 337-344.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults

AU - Woodside, JV

AU - McMahon, R

AU - Gallagher, AM

AU - Cran, GW

AU - Boreham, CA

AU - Murray, LJ

AU - STRAIN, JJ

AU - McNulty, H

AU - Robson, PJ

AU - Brown, KS

AU - Whitehead, AS

AU - Savage, M

AU - Young, IS

PY - 2004/12

Y1 - 2004/12

N2 - Aims: Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension. The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determinants of tHcy and PWV in healthy young adults. Methods and results: A total of 489 subjects aged 20-25 years participated. A fasting blood sample was taken and PWV measured using a non-invasive optical method. tHcy did not correlate with PWV, whether assessed at the aono-iliac segment (P = 0.18), the aorto-radial segment (P = 0.39) or the aorto-dorsalis-pedis segment (P = 0.22). When tHcy was classified into normal (< 15) and high (greater than or equal to 15 mumol/l) PWV did not differ between the two groups at any segment. PWV did not differ by MTHFR C677T or NOS3 G894T genotype, even when smoking and folate sub-groups were considered. Considering aortic PWV as a dependent variable, stepwise regression analysis showed that the only parameter entering the model for all segments was systolic blood pressure (aorto-iliac, P < 0.001; aorto-radial, P = 0.01; aorto-dorsalis-pedis, P = 0.001). Age, sex, COL1A1 genotype and triglycerides entered the model significantly for two of three segments. Conclusion: This study shows that arterial PWV is not associated with tHcy in a healthy young population. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

AB - Aims: Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension. The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determinants of tHcy and PWV in healthy young adults. Methods and results: A total of 489 subjects aged 20-25 years participated. A fasting blood sample was taken and PWV measured using a non-invasive optical method. tHcy did not correlate with PWV, whether assessed at the aono-iliac segment (P = 0.18), the aorto-radial segment (P = 0.39) or the aorto-dorsalis-pedis segment (P = 0.22). When tHcy was classified into normal (< 15) and high (greater than or equal to 15 mumol/l) PWV did not differ between the two groups at any segment. PWV did not differ by MTHFR C677T or NOS3 G894T genotype, even when smoking and folate sub-groups were considered. Considering aortic PWV as a dependent variable, stepwise regression analysis showed that the only parameter entering the model for all segments was systolic blood pressure (aorto-iliac, P < 0.001; aorto-radial, P = 0.01; aorto-dorsalis-pedis, P = 0.001). Age, sex, COL1A1 genotype and triglycerides entered the model significantly for two of three segments. Conclusion: This study shows that arterial PWV is not associated with tHcy in a healthy young population. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.atherosclerosis.2004.07.001

DO - 10.1016/j.atherosclerosis.2004.07.001

M3 - Article

VL - 177

SP - 337

EP - 344

JO - Atherosclerosis

T2 - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -