Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study

NR Simonsen, JFC Navajos, JM Martin-Moreno, JJ Strain, JK Huttunen, BC Martin, M Thamm, AFM Kardinaal, P van't Veer, FJ Kok, L Kohlmeier

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Abstract

The strongest evidence that monunsaturated fat may influence breast cancer risk comes from studies of southern European populations, in whom intake of oleic acid sources, particularly olive oil, appears protective. No previous study has examined the relation of adipose tissue fatty acid content to breast cancer in such a population. We used adipose biopsies with diverse fat intake patterns gathered in 5 European centers, including southern Europe (Malaga, Spain), to test the hypothesis that stores of oleic acid or other monounsaturates are inversely associated with breast cancer. Gluteal fat aspirates were obtained from 291 postmenopausal incident breast cancer patients and 351 control subjects, frequency-matched for age and catchment area. Logistic regression was used to model breast cancer by monounsaturates, with established risk factors controlled for. Oleic acid showed a strong inverse association with breast cancer in the Spanish center. The odds ratio for the difference between 75th and 25th percentiles was 0.40 (95% CI: 0.28, 0.58) in Malaga and 1.27 (0.88, 1.85) in all other centers pooled, with a peak at 2.36 (1.01, 5.50) for Zeist. Palmitoleic and myristoleic acids showed evidence of an inverse association outside Spain, and cis-vaccenic acid showed a positive association in 3 centers. These data do not support the hypothesis that increasing tissue stores of oleic acid are protective against breast cancer in non-Spanish populations, This finding implies that the strong protective associations reported for olive oil intake in dietary studies may be due to some other protective components of the oil and not to the direct effect of oleic acid uptake. Alternatively, high olive oil intake may indicate some other protective aspect of the lifestyle of these women.
LanguageEnglish
Pages134-141
JournalAmerican Journal of Clinical Nutrition
Volume68
Issue number1
Publication statusPublished - Jul 1998

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Monounsaturated Fatty Acids
Oleic Acid
Breast Neoplasms
Fats
Spain
Population
Adipose Tissue
Life Style
Oils
Fatty Acids
Logistic Models
Odds Ratio
Biopsy

Keywords

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Cite this

Simonsen, NR., Navajos, JFC., Martin-Moreno, JM., Strain, JJ., Huttunen, JK., Martin, BC., ... Kohlmeier, L. (1998). Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. American Journal of Clinical Nutrition, 68(1), 134-141.
Simonsen, NR ; Navajos, JFC ; Martin-Moreno, JM ; Strain, JJ ; Huttunen, JK ; Martin, BC ; Thamm, M ; Kardinaal, AFM ; van't Veer, P ; Kok, FJ ; Kohlmeier, L. / Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. In: American Journal of Clinical Nutrition. 1998 ; Vol. 68, No. 1. pp. 134-141.
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Simonsen, NR, Navajos, JFC, Martin-Moreno, JM, Strain, JJ, Huttunen, JK, Martin, BC, Thamm, M, Kardinaal, AFM, van't Veer, P, Kok, FJ & Kohlmeier, L 1998, 'Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study', American Journal of Clinical Nutrition, vol. 68, no. 1, pp. 134-141.

Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. / Simonsen, NR; Navajos, JFC; Martin-Moreno, JM; Strain, JJ; Huttunen, JK; Martin, BC; Thamm, M; Kardinaal, AFM; van't Veer, P; Kok, FJ; Kohlmeier, L.

In: American Journal of Clinical Nutrition, Vol. 68, No. 1, 07.1998, p. 134-141.

Research output: Contribution to journalArticle

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T1 - Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study

AU - Simonsen, NR

AU - Navajos, JFC

AU - Martin-Moreno, JM

AU - Strain, JJ

AU - Huttunen, JK

AU - Martin, BC

AU - Thamm, M

AU - Kardinaal, AFM

AU - van't Veer, P

AU - Kok, FJ

AU - Kohlmeier, L

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N2 - The strongest evidence that monunsaturated fat may influence breast cancer risk comes from studies of southern European populations, in whom intake of oleic acid sources, particularly olive oil, appears protective. No previous study has examined the relation of adipose tissue fatty acid content to breast cancer in such a population. We used adipose biopsies with diverse fat intake patterns gathered in 5 European centers, including southern Europe (Malaga, Spain), to test the hypothesis that stores of oleic acid or other monounsaturates are inversely associated with breast cancer. Gluteal fat aspirates were obtained from 291 postmenopausal incident breast cancer patients and 351 control subjects, frequency-matched for age and catchment area. Logistic regression was used to model breast cancer by monounsaturates, with established risk factors controlled for. Oleic acid showed a strong inverse association with breast cancer in the Spanish center. The odds ratio for the difference between 75th and 25th percentiles was 0.40 (95% CI: 0.28, 0.58) in Malaga and 1.27 (0.88, 1.85) in all other centers pooled, with a peak at 2.36 (1.01, 5.50) for Zeist. Palmitoleic and myristoleic acids showed evidence of an inverse association outside Spain, and cis-vaccenic acid showed a positive association in 3 centers. These data do not support the hypothesis that increasing tissue stores of oleic acid are protective against breast cancer in non-Spanish populations, This finding implies that the strong protective associations reported for olive oil intake in dietary studies may be due to some other protective components of the oil and not to the direct effect of oleic acid uptake. Alternatively, high olive oil intake may indicate some other protective aspect of the lifestyle of these women.

AB - The strongest evidence that monunsaturated fat may influence breast cancer risk comes from studies of southern European populations, in whom intake of oleic acid sources, particularly olive oil, appears protective. No previous study has examined the relation of adipose tissue fatty acid content to breast cancer in such a population. We used adipose biopsies with diverse fat intake patterns gathered in 5 European centers, including southern Europe (Malaga, Spain), to test the hypothesis that stores of oleic acid or other monounsaturates are inversely associated with breast cancer. Gluteal fat aspirates were obtained from 291 postmenopausal incident breast cancer patients and 351 control subjects, frequency-matched for age and catchment area. Logistic regression was used to model breast cancer by monounsaturates, with established risk factors controlled for. Oleic acid showed a strong inverse association with breast cancer in the Spanish center. The odds ratio for the difference between 75th and 25th percentiles was 0.40 (95% CI: 0.28, 0.58) in Malaga and 1.27 (0.88, 1.85) in all other centers pooled, with a peak at 2.36 (1.01, 5.50) for Zeist. Palmitoleic and myristoleic acids showed evidence of an inverse association outside Spain, and cis-vaccenic acid showed a positive association in 3 centers. These data do not support the hypothesis that increasing tissue stores of oleic acid are protective against breast cancer in non-Spanish populations, This finding implies that the strong protective associations reported for olive oil intake in dietary studies may be due to some other protective components of the oil and not to the direct effect of oleic acid uptake. Alternatively, high olive oil intake may indicate some other protective aspect of the lifestyle of these women.

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SN - 0002-9165

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Simonsen NR, Navajos JFC, Martin-Moreno JM, Strain JJ, Huttunen JK, Martin BC et al. Tissue stores of individual monounsaturated fatty acids and breast cancer: the EURAMIC study. American Journal of Clinical Nutrition. 1998 Jul;68(1):134-141.