Tissue factor expression on monocyte subpopulations during normal pregnancy

VA Holmes, Julie Wallace, WS Gilmore, P McFaul, HD Alexander

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    Pregnancy is often referred to as a hypercoagulable state due to changes in the haemostatic system. Tissue factor (TF) is the initiator of blood clotting in vivo. The effect of pregnancy on monocyte TF expression was determined in a longitudinal case control study (89 pregnant, 39 non-pregnant). Using whole blood flow cytometry and CD 14 as a monocyte marker, TF expression was measured on all CD 14 positive, CD14(Bright) and CD14(Dim) cells, TF expression was significantly lower in pregnant women than in non-pregnant control subjects, on all CD 14 positive cells at 20 and 35 weeks, on CD14(Bright) cells at 12 and 35 weeks and on CD14(Dim) cells at 20 weeks. Additionally, we report that a higher percentage of CD Will, than CD14(Bright) cells express TF. These results suggest that, in order to maintain homeostasis in haemostasis in an otherwise hypercoagulable state, monocyte TF expression is reduced during, normal pregnancy.
    LanguageEnglish
    Pages953-958
    JournalThrombosis and Haemostasis
    Volume87
    Issue number6
    Publication statusPublished - May 2002

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    Thromboplastin
    Monocytes
    Pregnancy
    Blood Coagulation
    Hemostatics
    Hemostasis
    Case-Control Studies
    Pregnant Women
    Flow Cytometry
    Homeostasis

    Cite this

    Holmes, VA., Wallace, J., Gilmore, WS., McFaul, P., & Alexander, HD. (2002). Tissue factor expression on monocyte subpopulations during normal pregnancy. Thrombosis and Haemostasis, 87(6), 953-958.
    Holmes, VA ; Wallace, Julie ; Gilmore, WS ; McFaul, P ; Alexander, HD. / Tissue factor expression on monocyte subpopulations during normal pregnancy. In: Thrombosis and Haemostasis. 2002 ; Vol. 87, No. 6. pp. 953-958.
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    abstract = "Pregnancy is often referred to as a hypercoagulable state due to changes in the haemostatic system. Tissue factor (TF) is the initiator of blood clotting in vivo. The effect of pregnancy on monocyte TF expression was determined in a longitudinal case control study (89 pregnant, 39 non-pregnant). Using whole blood flow cytometry and CD 14 as a monocyte marker, TF expression was measured on all CD 14 positive, CD14(Bright) and CD14(Dim) cells, TF expression was significantly lower in pregnant women than in non-pregnant control subjects, on all CD 14 positive cells at 20 and 35 weeks, on CD14(Bright) cells at 12 and 35 weeks and on CD14(Dim) cells at 20 weeks. Additionally, we report that a higher percentage of CD Will, than CD14(Bright) cells express TF. These results suggest that, in order to maintain homeostasis in haemostasis in an otherwise hypercoagulable state, monocyte TF expression is reduced during, normal pregnancy.",
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    Holmes, VA, Wallace, J, Gilmore, WS, McFaul, P & Alexander, HD 2002, 'Tissue factor expression on monocyte subpopulations during normal pregnancy', Thrombosis and Haemostasis, vol. 87, no. 6, pp. 953-958.

    Tissue factor expression on monocyte subpopulations during normal pregnancy. / Holmes, VA; Wallace, Julie; Gilmore, WS; McFaul, P; Alexander, HD.

    In: Thrombosis and Haemostasis, Vol. 87, No. 6, 05.2002, p. 953-958.

    Research output: Contribution to journalArticle

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    AB - Pregnancy is often referred to as a hypercoagulable state due to changes in the haemostatic system. Tissue factor (TF) is the initiator of blood clotting in vivo. The effect of pregnancy on monocyte TF expression was determined in a longitudinal case control study (89 pregnant, 39 non-pregnant). Using whole blood flow cytometry and CD 14 as a monocyte marker, TF expression was measured on all CD 14 positive, CD14(Bright) and CD14(Dim) cells, TF expression was significantly lower in pregnant women than in non-pregnant control subjects, on all CD 14 positive cells at 20 and 35 weeks, on CD14(Bright) cells at 12 and 35 weeks and on CD14(Dim) cells at 20 weeks. Additionally, we report that a higher percentage of CD Will, than CD14(Bright) cells express TF. These results suggest that, in order to maintain homeostasis in haemostasis in an otherwise hypercoagulable state, monocyte TF expression is reduced during, normal pregnancy.

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    Holmes VA, Wallace J, Gilmore WS, McFaul P, Alexander HD. Tissue factor expression on monocyte subpopulations during normal pregnancy. Thrombosis and Haemostasis. 2002 May;87(6):953-958.