Timing of cardiac surgical interventions and postoperative mortality in children with severe congenital heart defects across Europe: Data from the EUROlinkCAT study

Mads Damkjaer, Ester Garne, Maria Loane, Stine K Urhoj, Elisa Ballardini,, Clara Cavero-Carbonell, Alessio Coi, Laura Garcia-Villodre, Joanne Given, Mika Gissler, Anna Heino, Sue Jordan, Elizabeth Limb, Amanda J. Neville, Anna Pierini, Anka Rissmann, Joachim Tan, Ieuan Scanlon, Joan K Morris

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Abstract

Background
The purpose of this study was to evaluate the timing of the first cardiac surgery, the number of cardiac surgeries performed, and 30‐day postoperative mortality rate for children with severe congenital heart defects (sCHDs) in their first 5 years of life.

Methods and Results
This was a population‐based data linkage cohort study linking information from 9 European congenital anomaly registries to vital statistics and hospital databases. Data were extracted for 5693 children with sCHDs born from 1995 to 2004. Subgroup analyses were performed for specific types of sCHD. Children with sCHDs underwent their first surgical intervention at a median age of 3.6 (95% CI, 2.6–4.5) weeks. The timing of the first surgery for most subtypes of sCHD was consistent across Europe. In the first 5 years of life, children with hypoplastic left heart underwent the most cardiac surgeries, with a median of 4.4 (95% CI, 3.1–5.6). The 30‐day postoperative mortality rate in children aged <1 year ranged from 1.1% (95% CI, 0.5%–2.1%) for tetralogy of Fallot to 23% (95% CI, 12%–37%) for Ebstein anomaly. The 30‐day postoperative mortality rate was highest for children undergoing surgery in the first month of life. Overall 5‐year survival for sCHD was <90% for all sCHDs, except transposition of the great arteries, tetralogy of Fallot, and coarctation of the aorta.

Conclusions
There were no major differences among the 9 regions in the timing, 30‐day postoperative mortality rate, and number of operations performed for sCHD. Despite an overall good prognosis for most congenital heart defects, some lesions were still associated with substantial postoperative death.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJAHA: Journal of the American Heart Association
Volume12
Issue number24
Early online date18 Dec 2023
DOIs
Publication statusPublished online - 18 Dec 2023

Bibliographical note

This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No. 733001. The views presented here are those of the authors only, and the European Commission is not responsible for any use that may be made of the information presented here.

Keywords

  • Congenital Abnormalities
  • Information Storage and Retrieval
  • Cardiac Surgical Procedures
  • Registries
  • Routinely Collected Health Data
  • cardiac surgery
  • pediatric car
  • Congenital heart defects
  • pediatric cardiology
  • congenital heart defects

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