Three-dimensional (3D) bio-printing: A new frontier in oncology research

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Current research in oncology deploys methods that rely principally on two-dimensional (2D) mono-cell cultures and animal models. Although these methodologies have led to significant advancement in the development of novel experimental therapeutic agents with promising anticancer activity in the laboratory, clinicians still struggle to manage cancer in the clinical setting. The disappointing translational success is attributable mainly to poor representation and recreation of the cancer microenvironment present in human neoplasia. Three-dimensional (3D) bio-printed models could help to simulate this micro-environment, with recent bio-printing of live human cells demonstrating that effective in vitro replication is achievable. This literature review outlines up-to-date advancements and developments in the use of 3D bio-printed models currently being used in oncology research. These innovative advancements in 3D bio-printing open up a new frontier for oncology research and could herald an era of progressive clinical cancer therapeutics.
LanguageEnglish
Pages21-36
JournalWorld Journal of Clinical Oncology
Volume8
Issue number1
Early online date10 Feb 2017
DOIs
Publication statusE-pub ahead of print - 10 Feb 2017

Fingerprint

Research
Recreation
Neoplasms
Printing
Tumor Microenvironment
Animal Models
Cell Culture Techniques
Therapeutics
Three Dimensional Printing
In Vitro Techniques

Keywords

  • Cancer
  • Three-dimensional bio-printing
  • In vitro
  • In vivo
  • Biomaterials

Cite this

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title = "Three-dimensional (3D) bio-printing: A new frontier in oncology research",
abstract = "Current research in oncology deploys methods that rely principally on two-dimensional (2D) mono-cell cultures and animal models. Although these methodologies have led to significant advancement in the development of novel experimental therapeutic agents with promising anticancer activity in the laboratory, clinicians still struggle to manage cancer in the clinical setting. The disappointing translational success is attributable mainly to poor representation and recreation of the cancer microenvironment present in human neoplasia. Three-dimensional (3D) bio-printed models could help to simulate this micro-environment, with recent bio-printing of live human cells demonstrating that effective in vitro replication is achievable. This literature review outlines up-to-date advancements and developments in the use of 3D bio-printed models currently being used in oncology research. These innovative advancements in 3D bio-printing open up a new frontier for oncology research and could herald an era of progressive clinical cancer therapeutics.",
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Three-dimensional (3D) bio-printing: A new frontier in oncology research. / Charbe, Nitin; McCarron, Paul; Tambuwala, Murtaza.

In: World Journal of Clinical Oncology, Vol. 8, No. 1, 10.02.2017, p. 21-36.

Research output: Contribution to journalArticle

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