Thermodynamics of interaction of ionic liquids with lipid monolayer

G. Bhattacharya, S. Mitra, P. Mandal, S. Dutta, R. P. Giri, S. K. Ghosh

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

Understanding the interaction of ionic liquids with cellular membrane becomes utterly important to comprehend the activities of these liquids in living organisms. Lipid monolayer formed at the air–water interface is employed as a model system to follow this interaction by investigating important thermodynamic parameters. The penetration kinetics of the imidazolium-based ionic liquid 1-decyl-3-methylimidazolium tetrafluoroborate ([DMIM][BF4]) into the zwitterionic 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipid layer is found to follow the Boltzmann-like equation that reveals the characteristic time constant which is observed to be the function of initial surface pressure. The enthalpy and entropy calculated from temperature-dependent pressure–area isotherms of the monolayer show that the added ionic liquids bring about a disordering effect in the lipid film. The change in Gibbs free energy indicates that an ionic liquid with longer chain has a far greater disordering effect compared to an ionic liquid with shorter chain. The differential scanning calorimetric measurement on a multilamellar vesicle system shows the main phase transition temperature to shift to a lower value, which, again, indicates the disordering effect of the ionic liquid on lipid membrane. All these studies fundamentally point out that, when ionic liquids interact with lipid molecules, the self-assembled structure of a cellular membrane gets perturbed, which may be the mechanism of these molecules having adverse effects on living organisms.

Original languageEnglish
Pages (from-to)709-719
Number of pages11
JournalBiophysical Reviews
Volume10
Issue number3
DOIs
Publication statusPublished - 5 Jan 2018

Bibliographical note

Funding Information:
Acknowledgements SKG acknowledges the financial support received from UGC-DAE CSR (Mumbai Centre). We acknowledge the scientific discussions with Dr. P. Munshi and Dr. M. K. Mukhopadhyay.

Publisher Copyright:
© 2018, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

  • Cellular membrane
  • Ionic liquids (ILs)
  • Lipid monolayer
  • Thermodynamics

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