Therapeutic Potential of Quercetin in the Management of Type-2 Diabetes Mellitus

Prawej Ansari, ST Choudhury, V Seidel, AB Rahman, MA Aziz, AE Richi, A Rahman, UH Jafrin, JMA Hannan, Yasser Abdel-Wahab

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Abstract

Diabetes Mellitus (DM) is a metabolic disorder that is spreading alarmingly around the globe. Type-2 DM (T2DM) is characterized by low-grade inflammation and insulin resistance and
is closely linked to obesity. T2DM is mainly controlled by lifestyle/dietary changes and oral antidiabetic drugs but requires insulin in severe cases. Many of the drugs that are currently used to treat DM are costly and present adverse side effects. Several cellular, animal, and clinical studies have provided compelling evidence that flavonoids have therapeutic potential in the management of diabetes and its complications. Quercetin is a flavonoid, present in various natural sources, which has demonstrated in vitro and in vivo antidiabetic properties. It improves oral glucose tolerance, as well as pancreatic β-cell function to secrete insulin. It inhibits the α-glucosidase and DPP-IV enzymes, which prolong the half-life of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Quercetin also suppresses the release of pro-inflammatory markers such as IL-1β, IL-4, IL-6, and TNF-α. Further studies are warranted to elucidate the mode(s) of action of quercetin at the molecular level. This review demonstrates the therapeutic potential of quercetin in the management of T2DM.
Original languageEnglish
Article number1146
Pages (from-to)e1146
JournalLife
Volume12
Issue number8
Early online date28 Jul 2022
DOIs
Publication statusE-pub ahead of print - 28 Jul 2022

Keywords

  • diabetes
  • inflammatory markers
  • insulin
  • medicinal plants
  • quercetin

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