The variability of outcomes used in efficacy and effectiveness trials of alcohol brief interventions: A systematic review

Gillian W Shorter, JW Bray, Emma Giles, Amy O'Donnell, Anne Berman, Aisha Holloway, Nick Heather, Carolina Barbosa, Kelly Stockdale, Stephanie Scott, Mike Clarke, Dorothy Newbury-Birch

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: The purpose of this study was to characterize recent alcohol brief intervention (ABI) efficacy and effectiveness trials, summarize outcomes, and show how variability in outcomes and reporting compromises the evidence base. METHOD: A systematic review and narrative synthesis of articles from 10 databases were undertaken (January 2000-November 2017); study selection represented recent, readily available publications. The National Institute of Care Excellence (NICE) Public Health Guideline 24 (Alcohol use disorders: prevention) informed ABI definitions. The review was conducted using Centre for Reviews and Dissemination (CRD) guidance and pre-registered on PROSPERO (CRD42016047185). Seven a priori specified domains were used to classify outcomes: biomarkers, alcohol-related outcomes, economic factors/resource use, health measures, life impact, intervention factors, and psychological/behavioral factors. RESULTS: The search identified 405 trials from 401 eligible papers. In 405 trials, 2,641 separate outcomes were measured in approximately 1,560 different ways. The most common outcomes used were the number of drinks consumed in a week and frequency of heavy episodic drinking. Biomarkers were least frequently used. The most common primary outcome was weekly drinks. By trial type, the most frequent outcome in efficacy and effectiveness trials was frequency of heavy drinking. CONCLUSIONS: Consumption outcomes predominated; however, no single outcome was found in all trials. This comprehensive outcome map and methodological detail on ABI effectiveness and efficacy trials can aid decision making in future trials. There was a diversity of instruments, time points, and outcome descriptions in methods and results sections. Compliance with reporting guidance would support data synthesis and improve trial quality. This review establishes the need for a core outcome set (COS)/minimum data standard and supports the Outcome Reporting in Brief Interventions: Alcohol initiative (ORBITAL) to improve standards in the ABI field through a COS for effectiveness and efficacy randomized trials.

LanguageEnglish
Pages286-298
Number of pages13
JournalJournal of Studies on Alcohol and Drugs
Volume80
Issue number3
Early online date30 Jun 2019
DOIs
Publication statusE-pub ahead of print - 30 Jun 2019

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Keywords

  • Alcohol Drinking
  • Alcohol brief interventions
  • randomised control trial
  • randomized control trial
  • outcome assessment
  • core outcome set
  • systematic review
  • outcome map
  • minimum data standard
  • methodology

Cite this

Shorter, Gillian W ; Bray, JW ; Giles, Emma ; O'Donnell, Amy ; Berman, Anne ; Holloway, Aisha ; Heather, Nick ; Barbosa, Carolina ; Stockdale, Kelly ; Scott, Stephanie ; Clarke, Mike ; Newbury-Birch, Dorothy. / The variability of outcomes used in efficacy and effectiveness trials of alcohol brief interventions: A systematic review. 2019 ; Vol. 80, No. 3. pp. 286-298.
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Shorter, GW, Bray, JW, Giles, E, O'Donnell, A, Berman, A, Holloway, A, Heather, N, Barbosa, C, Stockdale, K, Scott, S, Clarke, M & Newbury-Birch, D 2019, 'The variability of outcomes used in efficacy and effectiveness trials of alcohol brief interventions: A systematic review', vol. 80, no. 3, pp. 286-298. https://doi.org/10.15288/jsad.2019.80.286

The variability of outcomes used in efficacy and effectiveness trials of alcohol brief interventions: A systematic review. / Shorter, Gillian W; Bray, JW; Giles, Emma; O'Donnell, Amy; Berman, Anne; Holloway, Aisha; Heather, Nick; Barbosa, Carolina; Stockdale, Kelly; Scott, Stephanie; Clarke, Mike; Newbury-Birch, Dorothy.

Vol. 80, No. 3, 30.06.2019, p. 286-298.

Research output: Contribution to journalArticle

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AU - Giles, Emma

AU - O'Donnell, Amy

AU - Berman, Anne

AU - Holloway, Aisha

AU - Heather, Nick

AU - Barbosa, Carolina

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AU - Scott, Stephanie

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