The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study.

Katherine O'Neill; Fidelma Moran; Michael M Tunney; J. Stuart Elborn; Ian Bradbury; Damien G Downey; Jackie Rendall; Judy M Bradley

doi:10.1136/bmjresp-2016-000168

The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study.

Katherine O'Neill, Fidelma Moran, Michael M Tunney, J. Stuart Elborn, Ian Bradbury, Damien G Downey, Jackie Rendall, Judy M Bradley

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

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Abstract

Background: Streamlining the timing of treatments in Cystic Fibrosis (CF) is important to optimise adherence whilst ensuring efficacy. The optimal timing of treatment with hypertonic saline (HTS) and airway clearance techniques (ACT) is unknown.Objectives: This study hypothesised that HTS before ACT would be more effective than HTS during ACT as measured by lung clearance index (LCI). Methods: Adults with CF providing written informed consent were randomised to a crossover trial of HTS before ACT or HTS during ACT on consecutive days. ACT treatment consisted of Acapella® Duet. Patients completed LCI and spirometry at baseline and 90 mins post treatment. Sputum was collected immediately post treatment. Patient perception of ease of clearance and satisfaction with treatment was recorded. Wilcoxon test was used and p

Original language	English
Journal	BMJ Open Respiratory Research
Volume	4
Issue number	1
DOIs	https://doi.org/10.1136/bmjresp-2016-000168
Publication status	Published (in print/issue) - 1 Jan 2017

Keywords

hypertonic saline
airway clearance
CF

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/bmjresp-2016-000168

Clean version re-suSEbmission post review Airways clearance and hypertonic saline (HTS) in CF 01dec 2016Author Accepted Manuscript, 306 KB

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O'Neill, K., Moran, F., Tunney, M. M., Elborn, J. S., Bradbury, I., Downey, D. G., Rendall, J., & Bradley, J. M. (2017). The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study. BMJ Open Respiratory Research, 4(1). https://doi.org/10.1136/bmjresp-2016-000168

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title = "The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study.",

abstract = "Background: Streamlining the timing of treatments in Cystic Fibrosis (CF) is important to optimise adherence whilst ensuring efficacy. The optimal timing of treatment with hypertonic saline (HTS) and airway clearance techniques (ACT) is unknown.Objectives: This study hypothesised that HTS before ACT would be more effective than HTS during ACT as measured by lung clearance index (LCI). Methods: Adults with CF providing written informed consent were randomised to a crossover trial of HTS before ACT or HTS during ACT on consecutive days. ACT treatment consisted of Acapella{\textregistered} Duet. Patients completed LCI and spirometry at baseline and 90 mins post treatment. Sputum was collected immediately post treatment. Patient perception of ease of clearance and satisfaction with treatment was recorded. Wilcoxon test was used and p",

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O'Neill, K, Moran, F, Tunney, MM, Elborn, JS, Bradbury, I, Downey, DG, Rendall, J & Bradley, JM 2017, 'The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study.', BMJ Open Respiratory Research, vol. 4, no. 1. https://doi.org/10.1136/bmjresp-2016-000168

The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study. / O'Neill, Katherine; Moran, Fidelma; Tunney, Michael M et al.
In: BMJ Open Respiratory Research, Vol. 4, No. 1, 01.01.2017.

Research output: Contribution to journal › Article › peer-review

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T1 - The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study.

AU - O'Neill, Katherine

AU - Moran, Fidelma

AU - Tunney, Michael M

AU - Elborn, J. Stuart

AU - Bradbury, Ian

AU - Downey, Damien G

AU - Rendall, Jackie

AU - Bradley, Judy M

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Streamlining the timing of treatments in Cystic Fibrosis (CF) is important to optimise adherence whilst ensuring efficacy. The optimal timing of treatment with hypertonic saline (HTS) and airway clearance techniques (ACT) is unknown.Objectives: This study hypothesised that HTS before ACT would be more effective than HTS during ACT as measured by lung clearance index (LCI). Methods: Adults with CF providing written informed consent were randomised to a crossover trial of HTS before ACT or HTS during ACT on consecutive days. ACT treatment consisted of Acapella® Duet. Patients completed LCI and spirometry at baseline and 90 mins post treatment. Sputum was collected immediately post treatment. Patient perception of ease of clearance and satisfaction with treatment was recorded. Wilcoxon test was used and p

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KW - airway clearance

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The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study.

Abstract

Keywords

UN SDGs

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