The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study.

Katherine O'Neill, Fidelma Moran, Michael M Tunney, J. Stuart Elborn, Ian Bradbury, Damien G Downey, Jackie Rendall, Judy M Bradley

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Streamlining the timing of treatments in Cystic Fibrosis (CF) is important to optimise adherence whilst ensuring efficacy. The optimal timing of treatment with hypertonic saline (HTS) and airway clearance techniques (ACT) is unknown.Objectives: This study hypothesised that HTS before ACT would be more effective than HTS during ACT as measured by lung clearance index (LCI). Methods: Adults with CF providing written informed consent were randomised to a crossover trial of HTS before ACT or HTS during ACT on consecutive days. ACT treatment consisted of Acapella® Duet. Patients completed LCI and spirometry at baseline and 90 mins post treatment. Sputum was collected immediately post treatment. Patient perception of ease of clearance and satisfaction with treatment was recorded. Wilcoxon test was used and p
LanguageEnglish
JournalBMJ Open Respiratory Research
Volume4
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

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Cystic Fibrosis
Cross-Over Studies
Therapeutics
Lung
Spirometry
Sputum
Informed Consent

Keywords

  • hypertonic saline
  • airway clearance
  • CF

Cite this

O'Neill, Katherine ; Moran, Fidelma ; Tunney, Michael M ; Elborn, J. Stuart ; Bradbury, Ian ; Downey, Damien G ; Rendall, Jackie ; Bradley, Judy M. / The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study. In: BMJ Open Respiratory Research. 2017 ; Vol. 4, No. 1.
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abstract = "Background: Streamlining the timing of treatments in Cystic Fibrosis (CF) is important to optimise adherence whilst ensuring efficacy. The optimal timing of treatment with hypertonic saline (HTS) and airway clearance techniques (ACT) is unknown.Objectives: This study hypothesised that HTS before ACT would be more effective than HTS during ACT as measured by lung clearance index (LCI). Methods: Adults with CF providing written informed consent were randomised to a crossover trial of HTS before ACT or HTS during ACT on consecutive days. ACT treatment consisted of Acapella{\circledR} Duet. Patients completed LCI and spirometry at baseline and 90 mins post treatment. Sputum was collected immediately post treatment. Patient perception of ease of clearance and satisfaction with treatment was recorded. Wilcoxon test was used and p",
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The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study. / O'Neill, Katherine; Moran, Fidelma; Tunney, Michael M; Elborn, J. Stuart; Bradbury, Ian; Downey, Damien G; Rendall, Jackie; Bradley, Judy M.

In: BMJ Open Respiratory Research, Vol. 4, No. 1, 01.01.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The timing of hypertonic saline (HTS) and airway clearance techniques (ACT) in adults with Cystic Fibrosis (CF) during pulmonary exacerbation: Pilot data form a randomised crossover study.

AU - O'Neill, Katherine

AU - Moran, Fidelma

AU - Tunney, Michael M

AU - Elborn, J. Stuart

AU - Bradbury, Ian

AU - Downey, Damien G

AU - Rendall, Jackie

AU - Bradley, Judy M

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AB - Background: Streamlining the timing of treatments in Cystic Fibrosis (CF) is important to optimise adherence whilst ensuring efficacy. The optimal timing of treatment with hypertonic saline (HTS) and airway clearance techniques (ACT) is unknown.Objectives: This study hypothesised that HTS before ACT would be more effective than HTS during ACT as measured by lung clearance index (LCI). Methods: Adults with CF providing written informed consent were randomised to a crossover trial of HTS before ACT or HTS during ACT on consecutive days. ACT treatment consisted of Acapella® Duet. Patients completed LCI and spirometry at baseline and 90 mins post treatment. Sputum was collected immediately post treatment. Patient perception of ease of clearance and satisfaction with treatment was recorded. Wilcoxon test was used and p

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KW - airway clearance

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