The synthesis of Androgen and Estrogen from cholesterol presented as a SBGN diagram

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Abstract

The synthesis of androgen and estrogen is a key process carried out in the human body. This is initiated from cholesterol. Pregnenolone is the key precursor here, which is synthesized from cholesterol with the help of desmolase which is present in the mitochondria. Each reaction in the pathway was important and it was found that even if one reaction did not take place, it could result in mutations. It was like a chain of events linked to each other. It also analyses diseases are associated with this pathway,which occur as a result of malfunctioning of genes or due to mutations. This paper deals with the pathway modelling of this process with the help of systems biology graphical notation (SBGN). This process enabled us to clearly identify the setbacks and provided a clearer view of the functional aspects.The pathway map was constructed using yEd which is a computational tool. This yED employs a flowchart like symbology to depict the various types of reactions. All the steps in the process have supporting data in the form of research papers or journal articles to back them up. Also excel sheets were used to record information about all the compounds and enzymes in a more organized way. Since this pathway diagram produces a clarified version of the process, it can be used for therapeutic and clinical purposes with staunch verification by research and statistics.
LanguageEnglish
DOIs
Publication statusPublished - 12 Nov 2013

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Androgens
Estrogens
Cholesterol
Pregnenolone
Mitochondria
Lyases
Genes
Statistics
Enzymes
Systems Biology

Keywords

  • androgen
  • cholesterol
  • estrogen
  • sbgn

Cite this

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title = "The synthesis of Androgen and Estrogen from cholesterol presented as a SBGN diagram",
abstract = "The synthesis of androgen and estrogen is a key process carried out in the human body. This is initiated from cholesterol. Pregnenolone is the key precursor here, which is synthesized from cholesterol with the help of desmolase which is present in the mitochondria. Each reaction in the pathway was important and it was found that even if one reaction did not take place, it could result in mutations. It was like a chain of events linked to each other. It also analyses diseases are associated with this pathway,which occur as a result of malfunctioning of genes or due to mutations. This paper deals with the pathway modelling of this process with the help of systems biology graphical notation (SBGN). This process enabled us to clearly identify the setbacks and provided a clearer view of the functional aspects.The pathway map was constructed using yEd which is a computational tool. This yED employs a flowchart like symbology to depict the various types of reactions. All the steps in the process have supporting data in the form of research papers or journal articles to back them up. Also excel sheets were used to record information about all the compounds and enzymes in a more organized way. Since this pathway diagram produces a clarified version of the process, it can be used for therapeutic and clinical purposes with staunch verification by research and statistics.",
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AB - The synthesis of androgen and estrogen is a key process carried out in the human body. This is initiated from cholesterol. Pregnenolone is the key precursor here, which is synthesized from cholesterol with the help of desmolase which is present in the mitochondria. Each reaction in the pathway was important and it was found that even if one reaction did not take place, it could result in mutations. It was like a chain of events linked to each other. It also analyses diseases are associated with this pathway,which occur as a result of malfunctioning of genes or due to mutations. This paper deals with the pathway modelling of this process with the help of systems biology graphical notation (SBGN). This process enabled us to clearly identify the setbacks and provided a clearer view of the functional aspects.The pathway map was constructed using yEd which is a computational tool. This yED employs a flowchart like symbology to depict the various types of reactions. All the steps in the process have supporting data in the form of research papers or journal articles to back them up. Also excel sheets were used to record information about all the compounds and enzymes in a more organized way. Since this pathway diagram produces a clarified version of the process, it can be used for therapeutic and clinical purposes with staunch verification by research and statistics.

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