The Si elegans Project – The Challenges and Prospects of Emulating Caenorhabditis elegans

Axel Blau, Frank Callaly, Seamus Cawley, Aedan Coffey, Alessandro De Mauro, Gorka Epelde, Lorenzo Ferrara, Finn Krewer, Carlo Liberale, Pedro Machado, Gregory Maclair, TM McGinnity, Fearghal Morgan, Andoni Mujika, Alessandro Petrushin, Gautier Robin, John Wade

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

Caenorhabditis elegans features one of the simplest nervous systems in nature, yet its biological information processing still evades our complete understanding. The position of its 302 neurons and almost its entire connectome has been mapped. However, there is only sparse knowledge on how its nervous system codes for its rich behavioral repertoire. The EU-funded Si elegans project aims at reverse-engineering C. elegans‘ nervous system function by its emulation. 302 in parallel interconnected field-programmable gate array (FPGA) neuronswill interact through their sensory and motor neurons with a biophysically accurate soft-body epresentation of the nematode in a virtual behavioral arena. Each FPGA will feature its own reprogrammable neural response model that researchers world-wide will be able to modify to test their neuroscientific hypotheses. In a closed-feedback loop, any sensory xperience of the virtual nematode in its virtual environment will be processed by sensory and subsequently interconnected neurons to result in motor commands at neuromuscular junctions at the hardware-software interface to actuate virtual muscles of the virtual nematode. Postural changes in the virtual world will lead to a new sensory experience and thus close the loop. In this contribution we present the overall concepts with special focus on the virtual embodiment of the nematode. For further information and recent news please visit http://www.si-elegans.eu.
LanguageEnglish
Title of host publicationBiomimetic and Biohybrid Systems
EditorsArmin Duff, Nathan F. Lepora, Anna Mura, Tony J. Prescott, Paul F. M. J. Verschure
Pages436-438
Volume8608
DOIs
Publication statusPublished - 1 Aug 2014

Fingerprint

Neurology
Neurons
Field programmable gate arrays (FPGA)
Reverse engineering
Virtual reality
Muscle
Feedback
Hardware

Keywords

  • Biomimicry
  • Brain-Inspired Computation
  • Nervous System Emulation
  • Soft Body Simulation
  • Virtual World Embodiment
  • Neurocomputational Response Models on FPGAs

Cite this

Blau, A., Callaly, F., Cawley, S., Coffey, A., De Mauro, A., Epelde, G., ... Wade, J. (2014). The Si elegans Project – The Challenges and Prospects of Emulating Caenorhabditis elegans. In A. Duff, N. F. Lepora, A. Mura, T. J. Prescott, & P. F. M. J. Verschure (Eds.), Biomimetic and Biohybrid Systems (Vol. 8608, pp. 436-438) https://doi.org/10.1007/978-3-319-09435-9_54
Blau, Axel ; Callaly, Frank ; Cawley, Seamus ; Coffey, Aedan ; De Mauro, Alessandro ; Epelde, Gorka ; Ferrara, Lorenzo ; Krewer, Finn ; Liberale, Carlo ; Machado, Pedro ; Maclair, Gregory ; McGinnity, TM ; Morgan, Fearghal ; Mujika, Andoni ; Petrushin, Alessandro ; Robin, Gautier ; Wade, John. / The Si elegans Project – The Challenges and Prospects of Emulating Caenorhabditis elegans. Biomimetic and Biohybrid Systems. editor / Armin Duff ; Nathan F. Lepora ; Anna Mura ; Tony J. Prescott ; Paul F. M. J. Verschure. Vol. 8608 2014. pp. 436-438
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Blau, A, Callaly, F, Cawley, S, Coffey, A, De Mauro, A, Epelde, G, Ferrara, L, Krewer, F, Liberale, C, Machado, P, Maclair, G, McGinnity, TM, Morgan, F, Mujika, A, Petrushin, A, Robin, G & Wade, J 2014, The Si elegans Project – The Challenges and Prospects of Emulating Caenorhabditis elegans. in A Duff, NF Lepora, A Mura, TJ Prescott & PFMJ Verschure (eds), Biomimetic and Biohybrid Systems. vol. 8608, pp. 436-438. https://doi.org/10.1007/978-3-319-09435-9_54

The Si elegans Project – The Challenges and Prospects of Emulating Caenorhabditis elegans. / Blau, Axel; Callaly, Frank; Cawley, Seamus; Coffey, Aedan; De Mauro, Alessandro; Epelde, Gorka; Ferrara, Lorenzo; Krewer, Finn; Liberale, Carlo; Machado, Pedro; Maclair, Gregory; McGinnity, TM; Morgan, Fearghal; Mujika, Andoni; Petrushin, Alessandro; Robin, Gautier; Wade, John.

Biomimetic and Biohybrid Systems. ed. / Armin Duff; Nathan F. Lepora; Anna Mura; Tony J. Prescott; Paul F. M. J. Verschure. Vol. 8608 2014. p. 436-438.

Research output: Chapter in Book/Report/Conference proceedingChapter

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AU - Blau, Axel

AU - Callaly, Frank

AU - Cawley, Seamus

AU - Coffey, Aedan

AU - De Mauro, Alessandro

AU - Epelde, Gorka

AU - Ferrara, Lorenzo

AU - Krewer, Finn

AU - Liberale, Carlo

AU - Machado, Pedro

AU - Maclair, Gregory

AU - McGinnity, TM

AU - Morgan, Fearghal

AU - Mujika, Andoni

AU - Petrushin, Alessandro

AU - Robin, Gautier

AU - Wade, John

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KW - Brain-Inspired Computation

KW - Nervous System Emulation

KW - Soft Body Simulation

KW - Virtual World Embodiment

KW - Neurocomputational Response Models on FPGAs

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VL - 8608

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EP - 438

BT - Biomimetic and Biohybrid Systems

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Blau A, Callaly F, Cawley S, Coffey A, De Mauro A, Epelde G et al. The Si elegans Project – The Challenges and Prospects of Emulating Caenorhabditis elegans. In Duff A, Lepora NF, Mura A, Prescott TJ, Verschure PFMJ, editors, Biomimetic and Biohybrid Systems. Vol. 8608. 2014. p. 436-438 https://doi.org/10.1007/978-3-319-09435-9_54