The role of surfactants and biosurfactants in the wound healing process: a review

Mandana Ohadi, Hamid Forootanfar, Negar Dehghannoudeh, Ibrahim M. Banat, Gholamreza Dehghannoudeh

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
59 Downloads (Pure)


Wound healing refers to the complex process of restoring the forms and functions of damaged tissues. Multiple growth factors and released cytokines tightly regulate the wound site. Healing processes can be disrupted by any alteration that would aggravate the damage and lengthen the repair process. Some of the conditions that may impair wound healing include infections and inflammation. Surfactants are amphiphilic compounds widely used in various formulations including detergents, food, pharmaceuticals and cosmetics. Biosurfactants, therefore, are surface-active compounds produced by biological agents, particularly yeast or bacteria, and represent a safer and environmentally preferred alternative to chemical surfactants. Numerous studies have targeted surface-active molecules as wound healing agents for their anti-inflammatory, antioxidant and antibacterial potential. This review focuses on surface-active molecules used in wound healing activities and analyses their effectiveness and mechanisms of action.

Original languageEnglish
Pages (from-to)xxxix-xlvi
Number of pages8
JournalJournal of Wound Care
Issue numberSup4a
Early online date1 Apr 2023
Publication statusPublished (in print/issue) - 8 Apr 2023

Bibliographical note

Publisher Copyright:
© 2023 MA Healthcare Ltd. All rights reserved.


  • adjuvant
  • biosurfactants
  • surfactants
  • wound
  • wound care
  • wound dressing
  • wound healing
  • Fundamentals and skills
  • Nursing (miscellaneous)
  • Humans
  • Wound Healing/physiology
  • Inflammation
  • Anti-Bacterial Agents/pharmacology
  • Antioxidants
  • Surface-Active Agents/pharmacology


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