The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung

Matthew Twigg, Simon Brockbank, Philip Lowery, Peter FitzGerald, Cliff Taggart, Sinead Weldon

Research output: Contribution to journalLiterature review

38 Citations (Scopus)

Abstract

Cystic fibrosis (CF) lung disease is an inherited condition with an incidence rate of approximately 1 in 2500 new born babies. CF is characterized as chronic infection of the lung which leads to inflammation of the airway. Sputum from CF patients contains elevated levels of neutrophils and subsequently elevated levels of neutrophil serine proteases. In a healthy individual these proteases aid in the phagocytic process by degrading microbial peptides and are kept in homeostatic balance by cognate antiproteases. Due to the heavy neutrophil burden associated with CF the high concentration of neutrophil derived proteases overwhelms cognate antiproteases.The general effects of this protease/antiprotease imbalance are impairedmucus clearance, increased and selfperpetuating inflammation, and impaired immune responses and tissue. To restore this balance antiproteases have been suggested as potential therapeutics or therapeutic targets. As such a number of both endogenous and synthetic antiproteases have been trialed with mixed success as therapeutics for CF lung disease.
LanguageEnglish
Article number293053
Number of pages10
JournalMediators of Inflammation
Volume2015
Publication statusPublished - 8 Jan 2015

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Serine Proteases
Protease Inhibitors
Cystic Fibrosis
Neutrophils
Lung
Peptide Hydrolases
Lung Diseases
Inflammation
Sputum
Therapeutics
Peptides
Incidence
Infection

Cite this

Twigg, M., Brockbank, S., Lowery, P., FitzGerald, P., Taggart, C., & Weldon, S. (2015). The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung. Mediators of Inflammation, 2015, [293053].
Twigg, Matthew ; Brockbank, Simon ; Lowery, Philip ; FitzGerald, Peter ; Taggart, Cliff ; Weldon, Sinead. / The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung. In: Mediators of Inflammation. 2015 ; Vol. 2015.
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abstract = "Cystic fibrosis (CF) lung disease is an inherited condition with an incidence rate of approximately 1 in 2500 new born babies. CF is characterized as chronic infection of the lung which leads to inflammation of the airway. Sputum from CF patients contains elevated levels of neutrophils and subsequently elevated levels of neutrophil serine proteases. In a healthy individual these proteases aid in the phagocytic process by degrading microbial peptides and are kept in homeostatic balance by cognate antiproteases. Due to the heavy neutrophil burden associated with CF the high concentration of neutrophil derived proteases overwhelms cognate antiproteases.The general effects of this protease/antiprotease imbalance are impairedmucus clearance, increased and selfperpetuating inflammation, and impaired immune responses and tissue. To restore this balance antiproteases have been suggested as potential therapeutics or therapeutic targets. As such a number of both endogenous and synthetic antiproteases have been trialed with mixed success as therapeutics for CF lung disease.",
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Twigg, M, Brockbank, S, Lowery, P, FitzGerald, P, Taggart, C & Weldon, S 2015, 'The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung', Mediators of Inflammation, vol. 2015, 293053.

The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung. / Twigg, Matthew; Brockbank, Simon; Lowery, Philip ; FitzGerald, Peter; Taggart, Cliff; Weldon, Sinead.

In: Mediators of Inflammation, Vol. 2015, 293053, 08.01.2015.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung

AU - Twigg, Matthew

AU - Brockbank, Simon

AU - Lowery, Philip

AU - FitzGerald, Peter

AU - Taggart, Cliff

AU - Weldon, Sinead

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N2 - Cystic fibrosis (CF) lung disease is an inherited condition with an incidence rate of approximately 1 in 2500 new born babies. CF is characterized as chronic infection of the lung which leads to inflammation of the airway. Sputum from CF patients contains elevated levels of neutrophils and subsequently elevated levels of neutrophil serine proteases. In a healthy individual these proteases aid in the phagocytic process by degrading microbial peptides and are kept in homeostatic balance by cognate antiproteases. Due to the heavy neutrophil burden associated with CF the high concentration of neutrophil derived proteases overwhelms cognate antiproteases.The general effects of this protease/antiprotease imbalance are impairedmucus clearance, increased and selfperpetuating inflammation, and impaired immune responses and tissue. To restore this balance antiproteases have been suggested as potential therapeutics or therapeutic targets. As such a number of both endogenous and synthetic antiproteases have been trialed with mixed success as therapeutics for CF lung disease.

AB - Cystic fibrosis (CF) lung disease is an inherited condition with an incidence rate of approximately 1 in 2500 new born babies. CF is characterized as chronic infection of the lung which leads to inflammation of the airway. Sputum from CF patients contains elevated levels of neutrophils and subsequently elevated levels of neutrophil serine proteases. In a healthy individual these proteases aid in the phagocytic process by degrading microbial peptides and are kept in homeostatic balance by cognate antiproteases. Due to the heavy neutrophil burden associated with CF the high concentration of neutrophil derived proteases overwhelms cognate antiproteases.The general effects of this protease/antiprotease imbalance are impairedmucus clearance, increased and selfperpetuating inflammation, and impaired immune responses and tissue. To restore this balance antiproteases have been suggested as potential therapeutics or therapeutic targets. As such a number of both endogenous and synthetic antiproteases have been trialed with mixed success as therapeutics for CF lung disease.

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M3 - Literature review

VL - 2015

JO - Mediators of Inflammation

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SN - 1466-1861

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Twigg M, Brockbank S, Lowery P, FitzGerald P, Taggart C, Weldon S. The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung. Mediators of Inflammation. 2015 Jan 8;2015. 293053.