The Role of Gut Microbiota Modulation Strategies in Obesity: The Applications and Mechanisms

Lingyue Shan, Akanksha Tyagi, Umair Shabbir, Xiuqin Chen, Selvakumar Vijayalakshmi, Pianpian Yan, Oh DeogHwan

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
7 Downloads (Pure)


Nowadays, obesity is a leading public health problem worldwide. The growing prevalence of obesity significantly accounts for other cardio-metabolic diseases, including hypertension and diabetes. Several studies have shown that obesity is strongly associated with genetic, environmental, lifestyle, and dietary factors, especially the disordered profiles of gut microbiota (GM). The present review concluded mechanistic studies and potential correspondent treatments for obesity. Specifically, the anti-obesity effects of food-derived compounds manipulating GM were highlighted. The potential limitations of bioactive compounds on absorption in the intestinal tract were also discussed. Thus, the future direction of fecal microbiota transplantation (FMT) as an approach to support modulating host GM (considered to be a potential therapeutic target for obesity) was discussed. This review shed light on the role of GM modulation strategies for the prevention/treatment of obesity.</jats:p>
Original languageEnglish
Article number376
Pages (from-to)1-15
Number of pages15
Issue number8
Publication statusPublished (in print/issue) - 8 Aug 2022


  • obese
  • intestinal flora
  • mechanism
  • bioactive food
  • dysbiosis


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