The Role of Gut Microbiota Modulation Strategies in Obesity: The Applications and Mechanisms

Lingyue Shan; Akanksha Tyagi; Umair Shabbir; Xiuqin Chen; Selvakumar Vijayalakshmi; Pianpian Yan; Oh DeogHwan

doi:10.3390/fermentation8080376

The Role of Gut Microbiota Modulation Strategies in Obesity: The Applications and Mechanisms

Lingyue Shan, Akanksha Tyagi, Umair Shabbir, Xiuqin Chen, Selvakumar Vijayalakshmi, Pianpian Yan, Oh DeogHwan

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Nowadays, obesity is a leading public health problem worldwide. The growing prevalence of obesity significantly accounts for other cardio-metabolic diseases, including hypertension and diabetes. Several studies have shown that obesity is strongly associated with genetic, environmental, lifestyle, and dietary factors, especially the disordered profiles of gut microbiota (GM). The present review concluded mechanistic studies and potential correspondent treatments for obesity. Specifically, the anti-obesity effects of food-derived compounds manipulating GM were highlighted. The potential limitations of bioactive compounds on absorption in the intestinal tract were also discussed. Thus, the future direction of fecal microbiota transplantation (FMT) as an approach to support modulating host GM (considered to be a potential therapeutic target for obesity) was discussed. This review shed light on the role of GM modulation strategies for the prevention/treatment of obesity.

Original language	English
Article number	376
Pages (from-to)	1-15
Number of pages	15
Journal	Fermentation
Volume	8
Issue number	8
DOIs	https://doi.org/10.3390/fermentation8080376
Publication status	Published (in print/issue) - 8 Aug 2022

Keywords

obese
intestinal flora
mechanism
bioactive food
dysbiosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/fermentation8080376

fermentation-08-00376-v2Final published version, 1.47 MBLicence: CC BY

Cite this

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abstract = "Nowadays, obesity is a leading public health problem worldwide. The growing prevalence of obesity significantly accounts for other cardio-metabolic diseases, including hypertension and diabetes. Several studies have shown that obesity is strongly associated with genetic, environmental, lifestyle, and dietary factors, especially the disordered profiles of gut microbiota (GM). The present review concluded mechanistic studies and potential correspondent treatments for obesity. Specifically, the anti-obesity effects of food-derived compounds manipulating GM were highlighted. The potential limitations of bioactive compounds on absorption in the intestinal tract were also discussed. Thus, the future direction of fecal microbiota transplantation (FMT) as an approach to support modulating host GM (considered to be a potential therapeutic target for obesity) was discussed. This review shed light on the role of GM modulation strategies for the prevention/treatment of obesity.",

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AU - Yan, Pianpian

AU - DeogHwan, Oh

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The Role of Gut Microbiota Modulation Strategies in Obesity: The Applications and Mechanisms

Abstract

Keywords

UN SDGs

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