The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study

T Hill, N Meunier, M Andriollo-Sanchez, D Ciarapica, I Hininger-Favier, A Polito, JM O'Connor, C Coudray, KD Cashman

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Abstract

Objective: To investigate the relationship between indices of zinc nutritive status and biochemical markers of bone turnover in older adult European subjects. Design: Use of baseline data from a multicentre prospective zinc intervention (ZENITH) study. Setting: Centres in France, Italy and Northern Ireland. Participants: A total of 387 healthy adults, aged 55-87 y. Methods: Zinc intake was assessed by 4-day recall records. Circulating and urinary biochemical zinc status measures were assessed by atomic absorption spectrophometry. Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC. Results: Zinc intake was negatively correlated with urinary Pyr and Dpyr (r= -0.298 and -0.304, respectively; P<0.0001), but was not correlated with bone formation markers. There was a tendency for serum zinc to be negatively correlated with urinary Dpyr (r= -0.211; P = 0.080). Erythrocyte zinc was negatively correlated with serum osteocalcin (r= -0.090; P<0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research Centre) the only significant association that remained was between serum osteocalcin and erythrocyte zinc (P = -0.124; P=0.011). Conclusions: There was some, albeit inconsistent, evidence of a relationship between zinc nutritive status and bone turnover in the older adult participants of the ZENITH study.
LanguageEnglish
PagesS73-S78
JournalEuropean Journal of Clinical Nutrition
Volume59
Issue numberSuppl.
DOIs
Publication statusPublished - Nov 2005

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Bone Remodeling
Zinc
Biomarkers
Osteocalcin
Serum
Erythrocytes
Northern Ireland
Osteogenesis
Italy
France
Alkaline Phosphatase
Enzyme-Linked Immunosorbent Assay
High Pressure Liquid Chromatography
Bone and Bones

Cite this

Hill, T., Meunier, N., Andriollo-Sanchez, M., Ciarapica, D., Hininger-Favier, I., Polito, A., ... Cashman, KD. (2005). The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study. European Journal of Clinical Nutrition, 59(Suppl.), S73-S78. https://doi.org/10.1038/sj.ejcn.1602303
Hill, T ; Meunier, N ; Andriollo-Sanchez, M ; Ciarapica, D ; Hininger-Favier, I ; Polito, A ; O'Connor, JM ; Coudray, C ; Cashman, KD. / The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study. In: European Journal of Clinical Nutrition. 2005 ; Vol. 59, No. Suppl. pp. S73-S78.
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abstract = "Objective: To investigate the relationship between indices of zinc nutritive status and biochemical markers of bone turnover in older adult European subjects. Design: Use of baseline data from a multicentre prospective zinc intervention (ZENITH) study. Setting: Centres in France, Italy and Northern Ireland. Participants: A total of 387 healthy adults, aged 55-87 y. Methods: Zinc intake was assessed by 4-day recall records. Circulating and urinary biochemical zinc status measures were assessed by atomic absorption spectrophometry. Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC. Results: Zinc intake was negatively correlated with urinary Pyr and Dpyr (r= -0.298 and -0.304, respectively; P<0.0001), but was not correlated with bone formation markers. There was a tendency for serum zinc to be negatively correlated with urinary Dpyr (r= -0.211; P = 0.080). Erythrocyte zinc was negatively correlated with serum osteocalcin (r= -0.090; P<0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research Centre) the only significant association that remained was between serum osteocalcin and erythrocyte zinc (P = -0.124; P=0.011). Conclusions: There was some, albeit inconsistent, evidence of a relationship between zinc nutritive status and bone turnover in the older adult participants of the ZENITH study.",
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Hill, T, Meunier, N, Andriollo-Sanchez, M, Ciarapica, D, Hininger-Favier, I, Polito, A, O'Connor, JM, Coudray, C & Cashman, KD 2005, 'The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study', European Journal of Clinical Nutrition, vol. 59, no. Suppl., pp. S73-S78. https://doi.org/10.1038/sj.ejcn.1602303

The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study. / Hill, T; Meunier, N; Andriollo-Sanchez, M; Ciarapica, D; Hininger-Favier, I; Polito, A; O'Connor, JM; Coudray, C; Cashman, KD.

In: European Journal of Clinical Nutrition, Vol. 59, No. Suppl., 11.2005, p. S73-S78.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study

AU - Hill, T

AU - Meunier, N

AU - Andriollo-Sanchez, M

AU - Ciarapica, D

AU - Hininger-Favier, I

AU - Polito, A

AU - O'Connor, JM

AU - Coudray, C

AU - Cashman, KD

PY - 2005/11

Y1 - 2005/11

N2 - Objective: To investigate the relationship between indices of zinc nutritive status and biochemical markers of bone turnover in older adult European subjects. Design: Use of baseline data from a multicentre prospective zinc intervention (ZENITH) study. Setting: Centres in France, Italy and Northern Ireland. Participants: A total of 387 healthy adults, aged 55-87 y. Methods: Zinc intake was assessed by 4-day recall records. Circulating and urinary biochemical zinc status measures were assessed by atomic absorption spectrophometry. Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC. Results: Zinc intake was negatively correlated with urinary Pyr and Dpyr (r= -0.298 and -0.304, respectively; P<0.0001), but was not correlated with bone formation markers. There was a tendency for serum zinc to be negatively correlated with urinary Dpyr (r= -0.211; P = 0.080). Erythrocyte zinc was negatively correlated with serum osteocalcin (r= -0.090; P<0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research Centre) the only significant association that remained was between serum osteocalcin and erythrocyte zinc (P = -0.124; P=0.011). Conclusions: There was some, albeit inconsistent, evidence of a relationship between zinc nutritive status and bone turnover in the older adult participants of the ZENITH study.

AB - Objective: To investigate the relationship between indices of zinc nutritive status and biochemical markers of bone turnover in older adult European subjects. Design: Use of baseline data from a multicentre prospective zinc intervention (ZENITH) study. Setting: Centres in France, Italy and Northern Ireland. Participants: A total of 387 healthy adults, aged 55-87 y. Methods: Zinc intake was assessed by 4-day recall records. Circulating and urinary biochemical zinc status measures were assessed by atomic absorption spectrophometry. Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC. Results: Zinc intake was negatively correlated with urinary Pyr and Dpyr (r= -0.298 and -0.304, respectively; P<0.0001), but was not correlated with bone formation markers. There was a tendency for serum zinc to be negatively correlated with urinary Dpyr (r= -0.211; P = 0.080). Erythrocyte zinc was negatively correlated with serum osteocalcin (r= -0.090; P<0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research Centre) the only significant association that remained was between serum osteocalcin and erythrocyte zinc (P = -0.124; P=0.011). Conclusions: There was some, albeit inconsistent, evidence of a relationship between zinc nutritive status and bone turnover in the older adult participants of the ZENITH study.

U2 - 10.1038/sj.ejcn.1602303

DO - 10.1038/sj.ejcn.1602303

M3 - Article

VL - 59

SP - S73-S78

JO - European Journal of Clinical Nutrition

T2 - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - Suppl.

ER -