The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study

Ontefetse Ntlholang, Kevin McCarroll, Eamon Laird, Anne M. Molloy, M Ward, H McNulty, L. Hoey, Catherine Hughes, J.J. Strain, Miriam Casey, Conal Cunningham

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Previous reports investigating adiposity and cognitive function in the population allude to a negative association, although the relationship in older adults is unclear. The aim of this study was to investigate the association of adiposity (BMI and waist:hip ratio (WHR)) with cognitive function in community-dwelling older adults (≥60 years). Participants included 5186 adults from the Trinity Ulster Department of Agriculture ageing cohort study. Neuropsychological assessment measures included the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Multi-variable linear regression models were
used to assess the association between adiposity and cognitive function adjusting for insulin resistance, inflammation and cerebrovascular disease. The mean ages were 80·3 (SD 6·7), 71·0 (SD 7·3) and 70·2 (SD 6·3) years on the cognitive, bone and hypertensive cohorts, respectively. In the cognitive cohort, BMI was positively associated with immediate and delay memory, visuospatial/constructional ability, language and MMSE, and negatively with FAB (log-transformed), whereas WHR was negatively associated with attention. In the bone cohort, BMI was not associated with any cognitive domain, whereas WHR was negatively associated with visuospatial/constructional ability, attention and MMSE. In the hypertensive cohort, BMI was not associated with any cognitive domain, whereas WHR was negatively associated with immediate and delayed memory, visuospatial/constructional ability, language and MMSE and positively with FAB (log-transformed). In the cognitive and bone cohorts, the association of WHR and attention disappeared by further controlling for C-reactive protein and HbA1C. In this study of older adults, central adiposity was a stronger predictor of poor cognitive performance than BMI. Older adults could benefit from targeted public health strategies aimed at reducing obesity and obeseogenic risk factors to avoid/prevent/slow cognitive dysfunction.
LanguageEnglish
Pages517-527
JournalBritish Journal of Nutrition
Volume120
Early online date30 Jul 2018
DOIs
Publication statusPublished - 14 Sep 2018

Fingerprint

Independent Living
Waist-Hip Ratio
Adiposity
Agriculture
Cognition
Cohort Studies
Aptitude
Population
Short-Term Memory
Bone and Bones
Linear Models
Language
Repression (Psychology)
Cerebrovascular Disorders
C-Reactive Protein
Insulin Resistance
Public Health
Obesity
Inflammation

Keywords

  • adiposity
  • BMI
  • waist
  • hip ratio
  • cognitive function
  • inflammation
  • C-reactive protein
  • Frontal assessment battery (FAB)
  • mini-mental state examination
  • Repeatable battery for the assessment of neuropsychological status
  • waist circumference
  • waist:hip ratio

Cite this

@article{240a42b25d3344a79d74f0c07d3c9cee,
title = "The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study",
abstract = "Previous reports investigating adiposity and cognitive function in the population allude to a negative association, although the relationship in older adults is unclear. The aim of this study was to investigate the association of adiposity (BMI and waist:hip ratio (WHR)) with cognitive function in community-dwelling older adults (≥60 years). Participants included 5186 adults from the Trinity Ulster Department of Agriculture ageing cohort study. Neuropsychological assessment measures included the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Multi-variable linear regression models wereused to assess the association between adiposity and cognitive function adjusting for insulin resistance, inflammation and cerebrovascular disease. The mean ages were 80·3 (SD 6·7), 71·0 (SD 7·3) and 70·2 (SD 6·3) years on the cognitive, bone and hypertensive cohorts, respectively. In the cognitive cohort, BMI was positively associated with immediate and delay memory, visuospatial/constructional ability, language and MMSE, and negatively with FAB (log-transformed), whereas WHR was negatively associated with attention. In the bone cohort, BMI was not associated with any cognitive domain, whereas WHR was negatively associated with visuospatial/constructional ability, attention and MMSE. In the hypertensive cohort, BMI was not associated with any cognitive domain, whereas WHR was negatively associated with immediate and delayed memory, visuospatial/constructional ability, language and MMSE and positively with FAB (log-transformed). In the cognitive and bone cohorts, the association of WHR and attention disappeared by further controlling for C-reactive protein and HbA1C. In this study of older adults, central adiposity was a stronger predictor of poor cognitive performance than BMI. Older adults could benefit from targeted public health strategies aimed at reducing obesity and obeseogenic risk factors to avoid/prevent/slow cognitive dysfunction.",
keywords = "adiposity, BMI, waist, hip ratio, cognitive function, inflammation, C-reactive protein, Frontal assessment battery (FAB), mini-mental state examination, Repeatable battery for the assessment of neuropsychological status, waist circumference, waist:hip ratio",
author = "Ontefetse Ntlholang and Kevin McCarroll and Eamon Laird and Molloy, {Anne M.} and M Ward and H McNulty and L. Hoey and Catherine Hughes and J.J. Strain and Miriam Casey and Conal Cunningham",
year = "2018",
month = "9",
day = "14",
doi = "10.1017/S0007114518001848",
language = "English",
volume = "120",
pages = "517--527",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",

}

The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study. / Ntlholang, Ontefetse; McCarroll, Kevin; Laird, Eamon; Molloy, Anne M.; Ward, M; McNulty, H; Hoey, L.; Hughes, Catherine; Strain, J.J.; Casey, Miriam; Cunningham, Conal.

In: British Journal of Nutrition, Vol. 120, 14.09.2018, p. 517-527.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study

AU - Ntlholang, Ontefetse

AU - McCarroll, Kevin

AU - Laird, Eamon

AU - Molloy, Anne M.

AU - Ward, M

AU - McNulty, H

AU - Hoey, L.

AU - Hughes, Catherine

AU - Strain, J.J.

AU - Casey, Miriam

AU - Cunningham, Conal

PY - 2018/9/14

Y1 - 2018/9/14

N2 - Previous reports investigating adiposity and cognitive function in the population allude to a negative association, although the relationship in older adults is unclear. The aim of this study was to investigate the association of adiposity (BMI and waist:hip ratio (WHR)) with cognitive function in community-dwelling older adults (≥60 years). Participants included 5186 adults from the Trinity Ulster Department of Agriculture ageing cohort study. Neuropsychological assessment measures included the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Multi-variable linear regression models wereused to assess the association between adiposity and cognitive function adjusting for insulin resistance, inflammation and cerebrovascular disease. The mean ages were 80·3 (SD 6·7), 71·0 (SD 7·3) and 70·2 (SD 6·3) years on the cognitive, bone and hypertensive cohorts, respectively. In the cognitive cohort, BMI was positively associated with immediate and delay memory, visuospatial/constructional ability, language and MMSE, and negatively with FAB (log-transformed), whereas WHR was negatively associated with attention. In the bone cohort, BMI was not associated with any cognitive domain, whereas WHR was negatively associated with visuospatial/constructional ability, attention and MMSE. In the hypertensive cohort, BMI was not associated with any cognitive domain, whereas WHR was negatively associated with immediate and delayed memory, visuospatial/constructional ability, language and MMSE and positively with FAB (log-transformed). In the cognitive and bone cohorts, the association of WHR and attention disappeared by further controlling for C-reactive protein and HbA1C. In this study of older adults, central adiposity was a stronger predictor of poor cognitive performance than BMI. Older adults could benefit from targeted public health strategies aimed at reducing obesity and obeseogenic risk factors to avoid/prevent/slow cognitive dysfunction.

AB - Previous reports investigating adiposity and cognitive function in the population allude to a negative association, although the relationship in older adults is unclear. The aim of this study was to investigate the association of adiposity (BMI and waist:hip ratio (WHR)) with cognitive function in community-dwelling older adults (≥60 years). Participants included 5186 adults from the Trinity Ulster Department of Agriculture ageing cohort study. Neuropsychological assessment measures included the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Multi-variable linear regression models wereused to assess the association between adiposity and cognitive function adjusting for insulin resistance, inflammation and cerebrovascular disease. The mean ages were 80·3 (SD 6·7), 71·0 (SD 7·3) and 70·2 (SD 6·3) years on the cognitive, bone and hypertensive cohorts, respectively. In the cognitive cohort, BMI was positively associated with immediate and delay memory, visuospatial/constructional ability, language and MMSE, and negatively with FAB (log-transformed), whereas WHR was negatively associated with attention. In the bone cohort, BMI was not associated with any cognitive domain, whereas WHR was negatively associated with visuospatial/constructional ability, attention and MMSE. In the hypertensive cohort, BMI was not associated with any cognitive domain, whereas WHR was negatively associated with immediate and delayed memory, visuospatial/constructional ability, language and MMSE and positively with FAB (log-transformed). In the cognitive and bone cohorts, the association of WHR and attention disappeared by further controlling for C-reactive protein and HbA1C. In this study of older adults, central adiposity was a stronger predictor of poor cognitive performance than BMI. Older adults could benefit from targeted public health strategies aimed at reducing obesity and obeseogenic risk factors to avoid/prevent/slow cognitive dysfunction.

KW - adiposity

KW - BMI

KW - waist

KW - hip ratio

KW - cognitive function

KW - inflammation

KW - C-reactive protein

KW - Frontal assessment battery (FAB)

KW - mini-mental state examination

KW - Repeatable battery for the assessment of neuropsychological status

KW - waist circumference

KW - waist:hip ratio

UR - https://pure.ulster.ac.uk/en/publications/the-relationship-between-adiposity-and-cognitive-function-in-a-la

U2 - 10.1017/S0007114518001848

DO - 10.1017/S0007114518001848

M3 - Article

VL - 120

SP - 517

EP - 527

JO - British Journal of Nutrition

T2 - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

ER -