The primary structure of ratfish insulin reveals an unusual mode of proinsulin processing

J. Michael Conlon; Eva Dafgård; Sture Falkmer; Lars Thim

doi:10.1016/0014-5793(86)81066-3

The primary structure of ratfish insulin reveals an unusual mode of proinsulin processing

J. Michael Conlon
, Eva Dafgård
, Sture Falkmer
, Lars Thim

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The primary structure of insulin from the Holocephalan fish, Hydrolagus colliei (the ratfish), has been established by automated Edman degradation as: {A figure is presented}.

Original language	English
Pages (from-to)	445-450
Number of pages	6
Journal	FEBS Letters
Volume	208
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(86)81066-3
Publication status	Published (in print/issue) - 24 Nov 1986

Funding

This work was supported by the Stiftung Volkswagenwerk and the Swedish Medical Research Council. We thank Professor N. Hilschmann, Max-Planck-Institut fiir Ex-perimentelleM edizin, Gettingen, for providing facilities for amino acid analysis.

Keywords

(Ratfish pancreas) Holocephalan Insulin C-peptide HPLC
The presence of a COOH-terminal extension to the B-chain is consistent with the occurrence of a single base mutation in the region of the gene encoding one of the dibasic residue processing sites

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10.1016/0014-5793(86)81066-3

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title = "The primary structure of ratfish insulin reveals an unusual mode of proinsulin processing",

abstract = "The primary structure of insulin from the Holocephalan fish, Hydrolagus colliei (the ratfish), has been established by automated Edman degradation as: \{A figure is presented\}.",

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AU - Falkmer, Sture

AU - Thim, Lars

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Y1 - 1986/11/24

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KW - The presence of a COOH-terminal extension to the B-chain is consistent with the occurrence of a single base mutation in the region of the gene encoding one of the dibasic residue processing sites

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The primary structure of ratfish insulin reveals an unusual mode of proinsulin processing

Abstract

Funding

Keywords

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