The Northern Ireland Baby Hearts Study: A Case-Control study using a hybrid data linkage method

Nichola McCullough, Helen Dolk, Maria Loane, Briege M Lagan, Casey Frank, Brian Craig

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Abstract

Background
The Northern Ireland (NI) Baby Hearts study aimed to investigate risk factors for congenital heart defects (CHD), and to investigate the health behaviours of a representative sample of NI pregnant women.


Methods
We performed a case-control study with hybrid data collection methods, including self-administered iPad questionnaire or postal questionnaire, information held in maternity records and linkage to prescription records. Cases (n=286) were recruited following diagnosis prenatally or postnatally, controls (n=966) were recruited during recruitment months in each maternity unit at 18-20 weeks gestation.


Findings
Refusal rates for questionnaire completion were low (7-8%). Among those recruited, consent for access and linkage to medical records was high (98%). Recruitment of both cases and controls was closely representative of the NI population in terms of age, area of residence and deprivation. There was considerable discordance between self-report questionnaires, maternity records and prescription records regarding medications taken in the first trimester, and between self-report questionnaires and maternity records regarding behaviours such as preconceptional folic acid, pregnancy planning, and smoking. However, there were no differences between cases and controls that would indicate recall bias.


Conclusions
Our results suggest that hybrid data collection approaches are a useful way forward for aetiological studies.
Original languageEnglish
Title of host publicationInternational Conference for Administrative Data Research
EditorsMark Elliot
Volume3
Edition2
Publication statusPublished - 14 Jun 2018
EventConference Proceedings for International Conference for Administrative Data Research - Queens University, Belfast, Northern Ireland, Belfast, Northern Ireland
Duration: 21 Jun 201822 Jun 2018
Conference number: 3rd
https://ijpds.org/issue/view/8

Publication series

NameInternational Journal of Population Data Science
PublisherSwansea University
ISSN (Print)2399-4908

Conference

ConferenceConference Proceedings for International Conference for Administrative Data Research
CountryNorthern Ireland
CityBelfast
Period21/06/1822/06/18
Internet address

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  • Cite this

    McCullough, N., Dolk, H., Loane, M., Lagan, B. M., Frank, C., & Craig, B. (2018). The Northern Ireland Baby Hearts Study: A Case-Control study using a hybrid data linkage method. In M. Elliot (Ed.), International Conference for Administrative Data Research (2 ed., Vol. 3). (International Journal of Population Data Science).