TY - JOUR
T1 - The Influence of Solvent Processing on Polyester Bioabsorable Polymers
AU - Dixon, D
AU - Manson, J
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in both medical device production and research. The influence of solvent casting and subsequent drying time was studied using thermal analysis, spectroscopy and weight measurement for four grades of 50 : 50 poly(lactic-co-glycolic acid) (PLGA) produced by using chloroform, dichloromethane, and acetone. The results demonstrate that solvent choice and PLGA molecular weight are critical factors in terms of solvent removal rate and maintaining sample integrity, respectively. The protocols widely employed result in high levels of residual solvent and a new protocol is presented together with solutions to commonly encountered problems.
AB - Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in both medical device production and research. The influence of solvent casting and subsequent drying time was studied using thermal analysis, spectroscopy and weight measurement for four grades of 50 : 50 poly(lactic-co-glycolic acid) (PLGA) produced by using chloroform, dichloromethane, and acetone. The results demonstrate that solvent choice and PLGA molecular weight are critical factors in terms of solvent removal rate and maintaining sample integrity, respectively. The protocols widely employed result in high levels of residual solvent and a new protocol is presented together with solutions to commonly encountered problems.
UR - https://www.scopus.com/pages/publications/84855666959
U2 - 10.1177/0885328210376997
DO - 10.1177/0885328210376997
M3 - Article
SN - 1530-8022
VL - 26
SP - 623
EP - 634
JO - Journal of Biomaterials Applications
JF - Journal of Biomaterials Applications
IS - 5
ER -
