TY - JOUR
T1 - The importance of accessory protein variants in the pathogenicity of SARS-CoV-2
AU - Hassan, Sk. Sarif
AU - Choudhury, Pabitra Pal
AU - Dayhoff, Guy W.
AU - Aljabali, Alaa A.a.
AU - Uhal, Bruce D.
AU - Lundstrom, Kenneth
AU - Rezaei, Nima
AU - Pizzol, Damiano
AU - Adadi, Parise
AU - Lal, Amos
AU - Soares, Antonio
AU - Abd El-aziz, Tarek Mohamed
AU - Brufsky, Adam M.
AU - Azad, Gajendra Kumar
AU - Sherchan, Samendra P.
AU - Baetas-da-cruz, Wagner
AU - Takayama, Kazuo
AU - Serrano-aroca, Ãngel
AU - Chauhan, Gaurav
AU - Palu, Giorgio
AU - Mishra, Yogendra Kumar
AU - Barh, Debmalya
AU - Santana Silva, Raner Jośe
AU - Andrade, Bruno Silva
AU - Azevedo, Vasco
AU - Góes-neto, Aristóteles
AU - Bazan, Nicolas G.
AU - Redwan, Elrashdy M.
AU - Tambuwala, Murtaza
AU - Uversky, Vladimir N.
N1 - Copyright © 2022 Elsevier Inc. All rights reserved.
PY - 2022/3/15
Y1 - 2022/3/15
N2 - The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.
AB - The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2.
KW - ORF10
KW - ORF3a
KW - ORF6
KW - ORF7a
KW - ORF7b
KW - ORF8
KW - Pathogenicity
KW - SARS-CoV-2
KW - Orf7b
KW - Orf7a
KW - Humans
KW - Viral Proteins
KW - Phylogeny
KW - Viroporin Proteins
KW - Orf10
KW - Orf8
KW - Sars-cov-2
KW - Genetic Variation
KW - COVID-19
KW - Orf6
KW - Orf3a
UR - http://www.scopus.com/inward/record.url?scp=85123570354&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/35085577/
UR - https://linkinghub.elsevier.com/retrieve/pii/S0003986122000091
U2 - 10.1016/j.abb.2022.109124
DO - 10.1016/j.abb.2022.109124
M3 - Article
C2 - 35085577
SN - 0003-9861
VL - 717
SP - 1
EP - 16
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
M1 - 109124
ER -
