The impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care: a cross-sectional retrospective analysis of UK primary and specialist care

Lola Loewenthal, John Busby, Ronald Mc Dowell, Thomas Brown, Hassan Burhan, Rekha Chaudhuri, Paddy Dennison, James Dodd, Simon Doe, Shoaib Faruqi, Robin Gore, Elfatih Idris, David Jackson, Mitesh Patel, Thomas Pantin, Ian D Pavord, Paul Pfeffer, David Price, Hitasha Rupani, Salman SiddiquiLiam Heaney, Andrew Menzies-gow

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2 Citations (Scopus)
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Abstract

After puberty, females are more likely to develop asthma and in a more severe form than males. The associations between asthma and sex are complex with multiple intrinsic and external factors. To evaluate the sex differences in the characteristics and treatment of patients with severe asthma (SA) in a real-world setting. Demographic, clinical and treatment characteristics for patients with SA in the UK Severe Asthma Registry (UKSAR) and Optimum Patient Care Research Database (OPCRD) were retrospectively analysed by sex using univariable and multivariable logistic regression analyses adjusted for year, age and hospital/practice. 3679 (60.9% female) patients from UKSAR and 18 369 patients (67.9% female) from OPCRD with SA were included. Females were more likely to be symptomatic with increased Asthma Control Questionnaire-6 (UKSAR adjusted OR (aOR) 1.14, 95% CI 1.09 to 1.18) and Royal College of Physicians-3 Question scores (OPCRD aOR 1.29, 95% CI 1.13 to 1.47). However, they had a higher forced expiratory volume in 1 second per cent (FEV %) predicted (UKSAR 68.7% vs 64.8%, p
Original languageEnglish
Article numberthorax-2023-220512
Pages (from-to)1-9
Number of pages9
JournalThorax
Early online date16 Dec 2023
DOIs
Publication statusPublished online - 16 Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 Author(s) (or their employer(s)).

Keywords

  • Asthma
  • Asthma Epidemiology
  • Asthma in primary care

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