The impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care: a cross-sectional retrospective analysis of UK primary and specialist care

Lola Loewenthal; John Busby; Ronald Mc Dowell; Thomas Brown; Hassan Burhan; Rekha Chaudhuri; Paddy Dennison; James Dodd; Simon Doe; Shoaib Faruqi; Robin Gore; Elfatih Idris; David Jackson; Mitesh Patel; Thomas Pantin; Ian D Pavord; Paul Pfeffer; David Price; Hitasha Rupani; Salman Siddiqui; Liam Heaney; Andrew Menzies-gow

doi:10.1136/thorax-2023-220512

The impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care: a cross-sectional retrospective analysis of UK primary and specialist care

Lola Loewenthal, John Busby, Ronald Mc Dowell, Thomas Brown, Hassan Burhan, Rekha Chaudhuri, Paddy Dennison, James Dodd, Simon Doe, Shoaib Faruqi, Robin Gore, Elfatih Idris, David Jackson, Mitesh Patel, Thomas Pantin, Ian D Pavord, Paul Pfeffer, David Price, Hitasha Rupani, Salman SiddiquiLiam Heaney, Andrew Menzies-gow

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Abstract

After puberty, females are more likely to develop asthma and in a more severe form than males. The associations between asthma and sex are complex with multiple intrinsic and external factors. To evaluate the sex differences in the characteristics and treatment of patients with severe asthma (SA) in a real-world setting. Demographic, clinical and treatment characteristics for patients with SA in the UK Severe Asthma Registry (UKSAR) and Optimum Patient Care Research Database (OPCRD) were retrospectively analysed by sex using univariable and multivariable logistic regression analyses adjusted for year, age and hospital/practice. 3679 (60.9% female) patients from UKSAR and 18 369 patients (67.9% female) from OPCRD with SA were included. Females were more likely to be symptomatic with increased Asthma Control Questionnaire-6 (UKSAR adjusted OR (aOR) 1.14, 95% CI 1.09 to 1.18) and Royal College of Physicians-3 Question scores (OPCRD aOR 1.29, 95% CI 1.13 to 1.47). However, they had a higher forced expiratory volume in 1 second per cent (FEV %) predicted (UKSAR 68.7% vs 64.8%, p

Original language	English
Article number	thorax-2023-220512
Pages (from-to)	1-9
Number of pages	9
Journal	Thorax
Early online date	16 Dec 2023
DOIs	https://doi.org/10.1136/thorax-2023-220512
Publication status	Published online - 16 Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 Author(s) (or their employer(s)).

Keywords

Asthma
Asthma Epidemiology
Asthma in primary care

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/thorax-2023-220512

Main Document_Manuscript ID thorax-2023-220512Author Accepted Manuscript, 364 KBLicence: CC BY-NC
Supplement _FIg1Other version, 353 KB

Cite this

Loewenthal, L., Busby, J., Mc Dowell, R., Brown, T., Burhan, H., Chaudhuri, R., Dennison, P., Dodd, J., Doe, S., Faruqi, S., Gore, R., Idris, E., Jackson, D., Patel, M., Pantin, T., Pavord, I. D., Pfeffer, P., Price, D., Rupani, H., ... Menzies-gow, A. (2023). The impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care: a cross-sectional retrospective analysis of UK primary and specialist care. Thorax, 1-9. Article thorax-2023-220512. Advance online publication. https://doi.org/10.1136/thorax-2023-220512

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title = "The impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care: a cross-sectional retrospective analysis of UK primary and specialist care",

abstract = "After puberty, females are more likely to develop asthma and in a more severe form than males. The associations between asthma and sex are complex with multiple intrinsic and external factors. To evaluate the sex differences in the characteristics and treatment of patients with severe asthma (SA) in a real-world setting. Demographic, clinical and treatment characteristics for patients with SA in the UK Severe Asthma Registry (UKSAR) and Optimum Patient Care Research Database (OPCRD) were retrospectively analysed by sex using univariable and multivariable logistic regression analyses adjusted for year, age and hospital/practice. 3679 (60.9% female) patients from UKSAR and 18 369 patients (67.9% female) from OPCRD with SA were included. Females were more likely to be symptomatic with increased Asthma Control Questionnaire-6 (UKSAR adjusted OR (aOR) 1.14, 95% CI 1.09 to 1.18) and Royal College of Physicians-3 Question scores (OPCRD aOR 1.29, 95% CI 1.13 to 1.47). However, they had a higher forced expiratory volume in 1 second per cent (FEV %) predicted (UKSAR 68.7% vs 64.8%, p",

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doi = "10.1136/thorax-2023-220512",

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Loewenthal, L, Busby, J, Mc Dowell, R, Brown, T, Burhan, H, Chaudhuri, R, Dennison, P, Dodd, J, Doe, S, Faruqi, S, Gore, R, Idris, E, Jackson, D, Patel, M, Pantin, T, Pavord, ID, Pfeffer, P, Price, D, Rupani, H, Siddiqui, S, Heaney, L & Menzies-gow, A 2023, 'The impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care: a cross-sectional retrospective analysis of UK primary and specialist care', Thorax, pp. 1-9. https://doi.org/10.1136/thorax-2023-220512

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AU - Brown, Thomas

AU - Burhan, Hassan

AU - Chaudhuri, Rekha

AU - Dennison, Paddy

AU - Dodd, James

AU - Doe, Simon

AU - Faruqi, Shoaib

AU - Gore, Robin

AU - Idris, Elfatih

AU - Jackson, David

AU - Patel, Mitesh

AU - Pantin, Thomas

AU - Pavord, Ian D

AU - Pfeffer, Paul

AU - Price, David

AU - Rupani, Hitasha

AU - Siddiqui, Salman

AU - Heaney, Liam

AU - Menzies-gow, Andrew

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KW - Asthma Epidemiology

KW - Asthma in primary care

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JO - Thorax

JF - Thorax

M1 - thorax-2023-220512

ER -

The impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care: a cross-sectional retrospective analysis of UK primary and specialist care

Abstract

Bibliographical note

Keywords

UN SDGs

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