THE GENOTYPE OF BONE-MARROW-DERIVED INFLAMMATORY CELLS DOES NOT ACCOUNT FOR DIFFERENCES IN SKELETAL-MUSCLE REGENERATION BETWEEN SJL/J AND BALB/C MICE

Christopher Mitchell, MD GROUNDS, JM PAPADIMITRIOU

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This study determined whether the genotype of bone marrow-derived inflammatory cells contributes to the more pronounced leukocytic exudation and extensive new muscle formation seen in SJL/J compared with BALB/c mice after a crush-injury (Mitchell et al. 1992). Female SJL/J mice were whole-body irradiated and reconstituted with male bone marrow from the BALB/c strain, and irradiated BALB/c females reconstituted with male SJL/J bone marrow. The mice were allowed to recover for 3 weeks and the tibialis anterior muscle (in a leg which had been protected from irradiation) was injured by crushing. At 3 and 10 days after injury the extent of necrotic debris, mononuclear leukocytic infiltration and new muscle formation was assessed in the muscles. The SJL/J mice reconstituted with BALB/c bone marrow showed extensive mononuclear leukocytic infiltration and clearance of necrotic debris when compared with BALB/c mice reconstituted with SJL/J bone marrow, and these strain-specific differences mirrored those seen with control bone marrow reconstituted hosts and non-irradiated hosts. The results show that the genotype of the bone mac-row-derived macrophages is not responsible for the superior regeneration of crush-injured skeletal muscle in SJL/J mice, and it appears that factors intrinsic to the muscle tissue may be of central importance.
LanguageEnglish
Pages407-413
JournalCell and Tissue Research
Volume280
Issue number2
Publication statusPublished - May 1995

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Inbred BALB C Mouse
Regeneration
Skeletal Muscle
Bone Marrow
Genotype
Muscles
Intrinsic Factor
Leg
Macrophages
Bone and Bones
Wounds and Injuries

Cite this

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title = "THE GENOTYPE OF BONE-MARROW-DERIVED INFLAMMATORY CELLS DOES NOT ACCOUNT FOR DIFFERENCES IN SKELETAL-MUSCLE REGENERATION BETWEEN SJL/J AND BALB/C MICE",
abstract = "This study determined whether the genotype of bone marrow-derived inflammatory cells contributes to the more pronounced leukocytic exudation and extensive new muscle formation seen in SJL/J compared with BALB/c mice after a crush-injury (Mitchell et al. 1992). Female SJL/J mice were whole-body irradiated and reconstituted with male bone marrow from the BALB/c strain, and irradiated BALB/c females reconstituted with male SJL/J bone marrow. The mice were allowed to recover for 3 weeks and the tibialis anterior muscle (in a leg which had been protected from irradiation) was injured by crushing. At 3 and 10 days after injury the extent of necrotic debris, mononuclear leukocytic infiltration and new muscle formation was assessed in the muscles. The SJL/J mice reconstituted with BALB/c bone marrow showed extensive mononuclear leukocytic infiltration and clearance of necrotic debris when compared with BALB/c mice reconstituted with SJL/J bone marrow, and these strain-specific differences mirrored those seen with control bone marrow reconstituted hosts and non-irradiated hosts. The results show that the genotype of the bone mac-row-derived macrophages is not responsible for the superior regeneration of crush-injured skeletal muscle in SJL/J mice, and it appears that factors intrinsic to the muscle tissue may be of central importance.",
author = "Christopher Mitchell and MD GROUNDS and JM PAPADIMITRIOU",
year = "1995",
month = "5",
language = "English",
volume = "280",
pages = "407--413",
journal = "Cell and Tissue Research",
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}

THE GENOTYPE OF BONE-MARROW-DERIVED INFLAMMATORY CELLS DOES NOT ACCOUNT FOR DIFFERENCES IN SKELETAL-MUSCLE REGENERATION BETWEEN SJL/J AND BALB/C MICE. / Mitchell, Christopher; GROUNDS, MD; PAPADIMITRIOU, JM.

In: Cell and Tissue Research, Vol. 280, No. 2, 05.1995, p. 407-413.

Research output: Contribution to journalArticle

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