The Genetic Links to anxiety and depression (GLAD) study: Online recruitment into the largest recontactable study of depression and anxiety

Molly Davies; Gursharan  Kalsi; C Armour; Ian Jones; Andrew  McIntosh; Daniel Smith; James Walters; John Bradley; Nathalie Kingston; Sofie Ashford; Ioana Beange; Anamaria  Brailean; Anthony Cleare; Jonathan Coleman; Charles Curtis; Susannah Curzons; Katrina Davis; L Dowey; Victor A Gault; Kimberley Goldsmith; Megan Bennett; Yoriko Hirose; Matthew Hotopf; Christopher Hübel; Carola Kanz; Jennifer Leng; Donald Lyall; Bethany Mason; Monika  McAtarsney-Kovacs; Dina Monssen; Alexei Moulton; Nigel Ovington; Elisavet Palaiologou; Carmine Pariante; Shivani Parikh; Alicia Peel; RK Price; Katharine Rimes; Henry Rogers; Jennifer Sambrook; Megan Skelton; Anna Spaul; Eddy Suarez; Bronte Sykes; Keith Thomas; Allan Young; Evangelos Vassos; David Veale; Katie White; Janet Wingrove; Thalia Eley; Gerome Breen

doi:10.1016/j.brat.2019.103503

The Genetic Links to anxiety and depression (GLAD) study: Online recruitment into the largest recontactable study of depression and anxiety

Molly Davies, Gursharan Kalsi, C Armour, Ian Jones, Andrew McIntosh, Daniel Smith, James Walters, John Bradley, Nathalie Kingston, Sofie Ashford, Ioana Beange, Anamaria Brailean, Anthony Cleare, Jonathan Coleman, Charles Curtis, Susannah Curzons, Katrina Davis, L Dowey, Victor A Gault, Kimberley GoldsmithMegan Bennett, Yoriko Hirose, Matthew Hotopf, Christopher Hübel, Carola Kanz, Jennifer Leng, Donald Lyall, Bethany Mason, Monika McAtarsney-Kovacs, Dina Monssen, Alexei Moulton, Nigel Ovington, Elisavet Palaiologou, Carmine Pariante, Shivani Parikh, Alicia Peel, RK Price, Katharine Rimes, Henry Rogers, Jennifer Sambrook, Megan Skelton, Anna Spaul, Eddy Suarez, Bronte Sykes, Keith Thomas, Allan Young, Evangelos Vassos, David Veale, Katie White, Janet Wingrove, Thalia Eley, Gerome Breen

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

47 Downloads (Pure)

Abstract

Background
Anxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research.
Methods
The Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact.
Results
Online recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants’ questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages.
Discussion
This paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression.

Original language	English
Article number	103503
Number of pages	28
Journal	Behaviour Research and Therapy
Volume	123
Issue number	103503
Early online date	24 Oct 2019
DOIs	https://doi.org/10.1016/j.brat.2019.103503
Publication status	Published - 1 Dec 2019

Keywords

Anxiety
Behavior genetics
Data sharing
Depression
Life events
Psychiatric genetics

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GLAD Study publication-October 2019Accepted author manuscript, 1.7 MBLicence: CC BY

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Davies, M., Kalsi, G., Armour, C., Jones, I., McIntosh, A., Smith, D., Walters, J., Bradley, J., Kingston, N., Ashford, S., Beange, I., Brailean, A., Cleare, A., Coleman, J., Curtis, C., Curzons, S., Davis, K., Dowey, L., Gault, V. A., ... Breen, G. (2019). The Genetic Links to anxiety and depression (GLAD) study: Online recruitment into the largest recontactable study of depression and anxiety. Behaviour Research and Therapy, 123(103503), [103503]. https://doi.org/10.1016/j.brat.2019.103503

Davies, Molly ; Kalsi, Gursharan ; Armour, C ; Jones, Ian ; McIntosh, Andrew ; Smith, Daniel ; Walters, James ; Bradley, John ; Kingston, Nathalie ; Ashford, Sofie ; Beange, Ioana ; Brailean, Anamaria ; Cleare, Anthony ; Coleman, Jonathan ; Curtis, Charles ; Curzons, Susannah ; Davis, Katrina ; Dowey, L ; Gault, Victor A ; Goldsmith, Kimberley ; Bennett, Megan ; Hirose, Yoriko ; Hotopf, Matthew ; Hübel, Christopher ; Kanz, Carola ; Leng, Jennifer ; Lyall, Donald ; Mason, Bethany ; McAtarsney-Kovacs, Monika ; Monssen, Dina ; Moulton, Alexei ; Ovington, Nigel ; Palaiologou, Elisavet ; Pariante, Carmine ; Parikh, Shivani ; Peel, Alicia ; Price, RK ; Rimes, Katharine ; Rogers, Henry ; Sambrook, Jennifer ; Skelton, Megan ; Spaul, Anna ; Suarez, Eddy ; Sykes, Bronte ; Thomas, Keith ; Young, Allan ; Vassos, Evangelos ; Veale, David ; White, Katie ; Wingrove, Janet ; Eley, Thalia ; Breen, Gerome. / The Genetic Links to anxiety and depression (GLAD) study: Online recruitment into the largest recontactable study of depression and anxiety. In: Behaviour Research and Therapy. 2019 ; Vol. 123, No. 103503.

@article{549e9d3d904a48b692bd406caa8ac507,

title = "The Genetic Links to anxiety and depression (GLAD) study: Online recruitment into the largest recontactable study of depression and anxiety",

abstract = "BackgroundAnxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research.MethodsThe Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact.ResultsOnline recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants{\textquoteright} questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages.DiscussionThis paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression.",

keywords = "Anxiety, Behavior genetics, Data sharing, Depression, Life events, Psychiatric genetics",

author = "Molly Davies and Gursharan Kalsi and C Armour and Ian Jones and Andrew McIntosh and Daniel Smith and James Walters and John Bradley and Nathalie Kingston and Sofie Ashford and Ioana Beange and Anamaria Brailean and Anthony Cleare and Jonathan Coleman and Charles Curtis and Susannah Curzons and Katrina Davis and L Dowey and Gault, {Victor A} and Kimberley Goldsmith and Megan Bennett and Yoriko Hirose and Matthew Hotopf and Christopher H{\"u}bel and Carola Kanz and Jennifer Leng and Donald Lyall and Bethany Mason and Monika McAtarsney-Kovacs and Dina Monssen and Alexei Moulton and Nigel Ovington and Elisavet Palaiologou and Carmine Pariante and Shivani Parikh and Alicia Peel and RK Price and Katharine Rimes and Henry Rogers and Jennifer Sambrook and Megan Skelton and Anna Spaul and Eddy Suarez and Bronte Sykes and Keith Thomas and Allan Young and Evangelos Vassos and David Veale and Katie White and Janet Wingrove and Thalia Eley and Gerome Breen",

year = "2019",

month = dec,

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doi = "10.1016/j.brat.2019.103503",

language = "English",

volume = "123",

journal = "Behaviour Research and Therapy",

issn = "0005-7967",

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number = "103503",

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Davies, M, Kalsi, G, Armour, C, Jones, I, McIntosh, A, Smith, D, Walters, J, Bradley, J, Kingston, N, Ashford, S, Beange, I, Brailean, A, Cleare, A, Coleman, J, Curtis, C, Curzons, S, Davis, K, Dowey, L, Gault, VA, Goldsmith, K, Bennett, M, Hirose, Y, Hotopf, M, Hübel, C, Kanz, C, Leng, J, Lyall, D, Mason, B, McAtarsney-Kovacs, M, Monssen, D, Moulton, A, Ovington, N, Palaiologou, E, Pariante, C, Parikh, S, Peel, A, Price, RK, Rimes, K, Rogers, H, Sambrook, J, Skelton, M, Spaul, A, Suarez, E, Sykes, B, Thomas, K, Young, A, Vassos, E, Veale, D, White, K, Wingrove, J, Eley, T & Breen, G 2019, 'The Genetic Links to anxiety and depression (GLAD) study: Online recruitment into the largest recontactable study of depression and anxiety', Behaviour Research and Therapy, vol. 123, no. 103503, 103503. https://doi.org/10.1016/j.brat.2019.103503

The Genetic Links to anxiety and depression (GLAD) study: Online recruitment into the largest recontactable study of depression and anxiety. / Davies, Molly; Kalsi, Gursharan ; Armour, C; Jones, Ian; McIntosh, Andrew ; Smith, Daniel; Walters, James; Bradley, John; Kingston, Nathalie; Ashford, Sofie; Beange, Ioana; Brailean, Anamaria ; Cleare, Anthony; Coleman, Jonathan; Curtis, Charles; Curzons, Susannah; Davis, Katrina; Dowey, L; Gault, Victor A; Goldsmith, Kimberley; Bennett, Megan; Hirose, Yoriko; Hotopf, Matthew; Hübel, Christopher; Kanz, Carola; Leng, Jennifer; Lyall, Donald; Mason, Bethany; McAtarsney-Kovacs, Monika ; Monssen, Dina; Moulton, Alexei; Ovington, Nigel; Palaiologou, Elisavet; Pariante, Carmine; Parikh, Shivani; Peel, Alicia; Price, RK; Rimes, Katharine; Rogers, Henry; Sambrook, Jennifer; Skelton, Megan; Spaul, Anna; Suarez, Eddy; Sykes, Bronte; Thomas, Keith; Young, Allan; Vassos, Evangelos; Veale, David; White, Katie; Wingrove, Janet; Eley, Thalia; Breen, Gerome.

In: Behaviour Research and Therapy, Vol. 123, No. 103503, 103503, 01.12.2019.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The Genetic Links to anxiety and depression (GLAD) study: Online recruitment into the largest recontactable study of depression and anxiety

AU - Davies, Molly

AU - Kalsi, Gursharan

AU - Armour, C

AU - Jones, Ian

AU - McIntosh, Andrew

AU - Smith, Daniel

AU - Walters, James

AU - Bradley, John

AU - Kingston, Nathalie

AU - Ashford, Sofie

AU - Beange, Ioana

AU - Brailean, Anamaria

AU - Cleare, Anthony

AU - Coleman, Jonathan

AU - Curtis, Charles

AU - Curzons, Susannah

AU - Davis, Katrina

AU - Dowey, L

AU - Gault, Victor A

AU - Goldsmith, Kimberley

AU - Bennett, Megan

AU - Hirose, Yoriko

AU - Hotopf, Matthew

AU - Hübel, Christopher

AU - Kanz, Carola

AU - Leng, Jennifer

AU - Lyall, Donald

AU - Mason, Bethany

AU - McAtarsney-Kovacs, Monika

AU - Monssen, Dina

AU - Moulton, Alexei

AU - Ovington, Nigel

AU - Palaiologou, Elisavet

AU - Pariante, Carmine

AU - Parikh, Shivani

AU - Peel, Alicia

AU - Price, RK

AU - Rimes, Katharine

AU - Rogers, Henry

AU - Sambrook, Jennifer

AU - Skelton, Megan

AU - Spaul, Anna

AU - Suarez, Eddy

AU - Sykes, Bronte

AU - Thomas, Keith

AU - Young, Allan

AU - Vassos, Evangelos

AU - Veale, David

AU - White, Katie

AU - Wingrove, Janet

AU - Eley, Thalia

AU - Breen, Gerome

PY - 2019/12/1

Y1 - 2019/12/1

N2 - BackgroundAnxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research.MethodsThe Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact.ResultsOnline recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants’ questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages.DiscussionThis paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression.

AB - BackgroundAnxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors, but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety and broad assessment of risks to facilitate future research.MethodsThe Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact.ResultsOnline recruitment was effective; 42,531 participants consented and 27,776 completed the questionnaire by end of July 2019. Participants’ questionnaire data identified very high rates of recurrent depression, severe anxiety, and comorbidity. Participants reported high rates of treatment receipt. The age profile of the sample is biased toward young adults, with higher recruitment of females and the more educated, especially at younger ages.DiscussionThis paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes, and treatment for anxiety and depression.

KW - Anxiety

KW - Behavior genetics

KW - Data sharing

KW - Depression

KW - Life events

KW - Psychiatric genetics

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U2 - 10.1016/j.brat.2019.103503

DO - 10.1016/j.brat.2019.103503

M3 - Article

C2 - 31715324

VL - 123

JO - Behaviour Research and Therapy

JF - Behaviour Research and Therapy

SN - 0005-7967

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